Human lung-derived exosomes mitigate ischemia-reperfusion injury by reducing inflammation and oxidative stress which leads to improved lung function. Can exosome therapy increase donor lung utilization? @rafapribeiroMD, @SSaddoughi 🫁 #LungTx. 🔗:

Unlike intact HM3 bend reliefs that permit biodebris accumulation, perforated HM3 bend-reliefs enable exfiltration of biodebris & infiltration of cells and collagen to mitigate potential graft obstruction risk. @soultanofswing . 🔗:

Thanks to our guests Joan Guzmán Bofarull and @MartaFarrero of @hospitalclinic for sharing their work and the experiences of the international consortium on #PGD. Listen to the episode here:.

The July #JHLTThePodcast is live today, exploring regional differences in #PrimaryGraftDysfunction and what we can learn from how outcomes play out in different parts of the world. #Cardiology #HeartTx #HeartTransplant #HeartTxp #HeartFailure

RT @soultanofswing: And it’s here! Fantastic to finally be a @TheJHLT author. Officially contributing to potential options for better outco….

Should we go back to the clinical criteria for pathologic antibody mediated rejection? This study shows that pAMR+/DSA+ patients with allograft dysfunction represent a disproportionate # of #hearttransplant patients with poor outcomes. 🫀 @UCSDCardiology cc @ahajduczok. 🔗:.

piRNAs—once thought to act only in germ cells—are emerging as noninvasive biomarkers of cardiac injury and #transplant rejection. A new study finds 7 piRNAs elevated in heart rejection, hinting at a future of biopsy-free, precision transplant care. 🔗:

🧵 Understanding #CAV in the new area of multi-modality imaging: caution in navigating the intersection of coronary angiogram and PET to better understand macro and micro vascular disease in the transplanted heart. 🫀. 🔗:

Is all ISHLT CAV 1 the same? We found patients with ISHLT CAV 1 and >30% stenosis had nearly 3x the risk of death/re-tx compared with <30% stenosis. Patients with ISHLT CAV 1 & < 30% stenosis that have a reduced myocardial blood flow had a 35% absolute increase in death/re-tx.

Presence of piRNA in endomyocardial tissue and serum samples of patients after #hearttransplant. 🫀 Perez-Carrillo et al. propose a novel circulating piRNA panel for the detection of cardiac allograft rejection. @DMTCIISLAFE . 🔗:

Establishing a high-volume cardiac arrest center providing an extracorporeal #cardiopulmonary resuscitation service may increase the number of organ donors. In addition, the performances of donated organs were high and comparable between both treatment methods. @JanaSmlc . 🔗:.

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On #JHLTThePodcast, we explore a study from lead author Nikil Prasad @ColumbiaMed on grading mild #CAV and the value of using physiologic vs #PET/#CT assessment for added risk stratification. @DSchibilsky @MartyTamMD

Patients 65+ are the fastest-growing group on the U.S. #hearttransplant list. 📈 To guide listing decisions, we must account for on-list outcomes and avoid immortal time bias—linking Intermacs + SRTR data is key. 🫀 @TomCascinoMD. 🔗:

From the SOLSTICE study, Maribavir shows effectiveness for post-transplant CMV viremia clearance and fewer treatment discontinuations due to adverse events, as compared to investigator-assigned treatments. 🔗:

A novel cardioprotective perfusion protocol preserved function in marginal porcine hearts during 9 hrs of normothermic #exsitu perfusion. Stable indices + preload-responsiveness suggest transplant viability—advancing donor heart preservation tech. 🫀. 🔗:

🧵 How can we use multi-omics in Lung IRI drug discovery? Dr. Shigemura provides insight into this important question. 🫁 #Editorial. 🔗:

New findings in #lungtransplantation: 10 traditional Chinese medicine ingredients for ischemia-reperfusion injury treatment were discovered. The ingredient with the most potential, baicalein, reduced IRI by inhibiting AGEs in rat models. 🫁 @22tiandong . 🔗:.

🧵 RV reserve assessment ready for clinical practice? Amazing insights from exercise 3D echocardiography. #Editorial . 🔗:

Exercise RHC-3Decho to study the #RV contractile reserve in HFpEF and #PVD: exhausted reserve is associated with RV dilation and limited exercise capacity due to reduced CO reserve, and not pulmonary vascular load 🫁 @cla_baratto, @CaravitaSergio . 🔗: