Tom Snelling
@TWSnelling
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Postdoc with Philip Cohen @mrcppu @dundeeuni with an interest in cell signalling and rare diseases!
Dundee
Joined February 2019
Excited to share our preprint reporting on the discovery of a new ALPK1 variant causing ROSAH syndrome in a family with 7 affected members! We also characterise this variant, showing its constitutive activity in cells #ROSAH #ALPK1 #mrcppu #UoDLifeSciences
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RT @TrendsBiochem: Available online - the Review "Diseases caused by altered specificity of a #proteinkinase for its allosteric activators"….
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RT @bioprotocolbyte: Quantitative Measurement of the Kinase Activity of Wildtype ALPK1 and Disease-Causing ALPK1 Mutants Using Cell-Free Ra….
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RT @iDikic2: How #autophagy influences the regulation of MHC-I class receptors and regulates #immune evasion of #cancer?.A new role for an….
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RT @MatthewACoelho: Now open – a CRUK-funded PhD clinical research training fellowship in my team at the Wellcome Sanger Institute. https:/….
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RT @DrArpan100: JOB ALERT! MND Accelerator Award funded postdoctoral position in my lab @mrcppu is now LIVE. We will use pooled CRISPR scr….
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Happy to share two protocols describing how to study #ALPK1 disease-causing variants using cell-based and cell-free kinase assays! They were used in our recent preprint on #ROSAH syndrome. (.#UoDLifeSciences
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RT @Garnettlab: Delighted to share our work in @NatureGenet using base editing to map genetic mechanisms of drug resistance. If you're int….
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RT @UoDLifeSciences: Congrats to Celest Tay @taycell & Oliwia Mruk @olimruk who received Highly Commended Awards in the Life Science catego….
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RT @mrcppu: Congratulations Elisha and Catriona: Professor Sir Philip Cohen's 50th and 51st PhD students awarded their degress https://t.co….
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RT @gpsapkota: An excellent postdoctoral opportunity to join @sapkota_mrcppu to work on WNT signalling and colorectal cancer. We are lookin….
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RT @BiochemSoc: Congratulations to @TWSnelling and @OyieJessica for receiving International Sponsored Places to attend the Biomolecular Hor….
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Thrilled to have been awarded the Howard Elder Prize for my work on ALPK1😃. This kinase is activated by bacterial ADP-heptose, but mutations that cause a genetic disease and a rare cancer allow it to also be activated by human metabolites! #ALPK1 @mrcppu.@UoDLifeSciences
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RT @rbdamgaard: 📢 Are you interested in joining our lab in Copenhagen🇩🇰 as a #postdoc? We are an ambitious and friendly research group 👩🔬….
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Thrilled to see this research published! ALPK1 is a kinase activated by bacterial ADP-heptose, but disease-causing mutations allow it to also be activated by human metabolites, thereby leading to chronic signalling! .#ALPK1 #ROSAH @mrcppu @UoDLifeSciences
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Very happy to see my PhD work published 😊.
Snelling et al report advances in understanding how activation of ALPK1 by ADP-heptose triggers an immune signalling pathway coordinated by the E3 ligases TRAF6, c-IAP1 and LUBAC
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Very excited to share my first preprint where I report advances in understanding how activation of ALPK1 by ADP-heptose triggers an immune signalling pathway coordinated by the E3 ligases TRAF6, c-IAP1 and LUBAC #ubiqitin #ALPK1 @mrcppu @UoDLifeSciences
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RT @Dr_Ian_Kelsall: Our updated #ubiquitin and #glycotime crossover paper is now online at @embojournal. Want to see what we have added sin….
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