Synthego
@Synthego
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CRISPR Solutions for Every Milestone. 🧬
California, USA
Joined August 2012
🚀 Upgrade Your CRISPR Toolkit: Get hfCas12Max Nuclease 50% Off – Limited Time Only! Still using that old nuclease that makes you want to cry (or at least sigh)? 😩 Time for an upgrade! Gene edit like a pro and use promo code HFCAS12MAX50 at checkout.🧬 https://t.co/83dTF6enF4
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🚨 New blog: "The Science Behind Chemically Modified gRNA" 🚨 Discover how chemically modified guide RNAs are advancing CRISPR precision and efficiency for therapeutic development and research! 🧬 Check out the full article here: ⬇️ https://t.co/glHdTuQUlr
synthego.com
Adding chemical modifications to CRISPR gRNAs is crucial. This blog explores why chemical modifications are necessary, the different types, and their applications.
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⬇️ New hfCas12Max data ⬇️ In proof-of-concept studies, the LNP-hfCas12Max system was administered to HBV-infected mouse models, leading to significant reductions in serum HBsAg and HBV DNA levels. Curious to see the data behind these results? 👇 https://t.co/ePQWONHyIv
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🧵 5/5 Want to dive into their research and learn more about how it's improving CRISPR quality control? 🤓 Click the link to explore the full work! #CRISPR
https://t.co/3D16JbWmHP
liebertpub.com
Mass spectrometry (MS) has long been used for quality control of oligonucleotide therapeutics, including single-guide RNAs (sgRNAs) for clustered regularly interspaced short palindromic repeats...
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🧵 4/5 The study is optimized for 100-nucleotide sgRNAs, but you can easily adapt it for other RNA molecule lengths like 25-nucleotide siRNAs by truncating the conserved regions in the surrogates - Flexibility for your specific research needs! 🧬
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🧵 3/5 They also created RNA standard sequences with distinct masses to avoid overlap with impurities. This makes their approach highly adaptable for other nucleic acid MS assays, helping researchers boost the accuracy of their MS methods. 🔍
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🧵 2/5 No need for isotope-labeled controls! 🙌 Compared to traditional QC methods like LC or LC-MS, stand-alone MS is faster and resource-efficient. 🚀
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🎯 Advancing CRISPR Quality Control with Mass Spectrometry 🔬 🧵 1/5 Puzhou & Danny have shown that mass spectrometry (MS) can reliably detect critical impurities in sgRNAs, and the best part? https://t.co/3D16JbWmHP
liebertpub.com
Mass spectrometry (MS) has long been used for quality control of oligonucleotide therapeutics, including single-guide RNAs (sgRNAs) for clustered regularly interspaced short palindromic repeats...
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Say goodbye to the headaches of traditional nuclease & CRISPR gRNA ordering platforms! Our easy-to-use interface eliminates inefficiencies and simplifies YOUR experience. New to ordering? Let us show you how quick & easy it is to place your order TODAY!👇 https://t.co/6tdSfaKxly
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Our very own Jason Miller will attend the @alliancerm 2024 Cell & Gene Meeting on the Mesa! Collaboration is key to overcoming challenges in bringing cell & gene therapies to market and saving lives. Connect with Jason in Phoenix to learn about our CRISPR solutions. #CGMesa24
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Jimi Olaghere, cured of sickle cell disease with CRISPR, made history by summiting Mt. Kilimanjaro! ⛰️ His climb with the Timmerman Traverse raised $2.2M for sickle cell research in Africa! 🌍 A true symbol of resilience and hope.
timmermanreport.com
Four years after being functionally cured of sickle cell disease with a CRISPR gene-editing therapy, Jimi Olaghere has set a new world record for patients with this chronic and deadly disease....
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Not sure what all the fuss is about when it comes to chemically modified gRNAs? In this blog, we discuss why they are necessary, the different types and their applications, and how Synthego’s chemically modified gRNAs can ensure clinical success. #CRISPR
https://t.co/glHdTuQmvT
synthego.com
Adding chemical modifications to CRISPR gRNAs is crucial. This blog explores why chemical modifications are necessary, the different types, and their applications.
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Their work shows how Mass Spectrometry (ESI-QTOF-MS) can quantitatively detect even the tiniest variations in sgRNA samples for CRISPR-Cas9 systems. With their cutting-edge technique, they’ve pushed the boundaries of analysis, ensuring SpCas9 sgRNAs are more precise than ever. 🎯
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🚨 Big News in CRISPR Research! 🚨 Juan Avila (Danny) and Puzhou Wang just dropped a groundbreaking study that could change the game in CRISPR quality control! 🎤 💥 Publication link 🔗 https://t.co/3D16JbVOSh
#CRISPR
liebertpub.com
Mass spectrometry (MS) has long been used for quality control of oligonucleotide therapeutics, including single-guide RNAs (sgRNAs) for clustered regularly interspaced short palindromic repeats...
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Cutting-edge CRISPR? We’ve maxed it out! 🚀 Join Casey Jowdy as he breaks down hfCas12Max, our game-changing nuclease that outperforms traditional Cas nucleases and powers up therapeutics with unmatched precision. 🔬 Watch here👇
synthego.com
In this video, Casey Jowdy, Senior Product Manager at Synthego, will describe a high fidelity Cas12 variant, hfCas12Max, and demonstrate a variety of applications where hfCas12Max performs superiorly...
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CRISPR opened up new paths for therapies by expanding access to once "uneditable" genes. Discover how novel CRISPR nucleases are not only advancing science but also can protect your hard work. Read More In Our Blog https://t.co/uYf2LHfyYR
#CRISPR
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Our team traded pipettes for golf clubs, balancing precision science with fun on the fairway. It was a tee-rific time with many laughs and memories. We believe in balancing precision science with some fun on the fairway. After all, a little R&R can drive innovation! ⛳️
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