
Steven Brem
@StevenBremMD
Followers
3K
Following
3K
Media
608
Statuses
2K
Professor of Neurosurgery at the University of Pennsylvania, neurosurgeon, scientist, innovator, advancing clinical trials to meet unmet needs in neuro-oncology
Joined December 2016
Excited to work with @NdukaAmankulor to announce the 12th Penn Brain Tumor CME on 1.31.2025. Keynotes by Ganesh Rao, MD @DoctorGRao on #LITT - From Laboratory to Clinical Applications, and Ingo K. Mellinghoff, MD, FACP, on the #INDIGO Trial: Paradigm changes for #IDHmutant
2
2
47
10/10 For a comprehensive summary of Best Practice Guidelines for #braininjury, see the @AmCollSurgeons publication best-practices-guidelines-traumatic-brain-injury.pdf
0
0
1
9/10 Future directions in the management of #TBI and innovative approaches are described, including current clinical trials using #erythropoietin (neuroprotection); #N-acetylcysteine (antioxidant); c) #amantadine (cognitive function). 🧵
1
0
2
8/10 a)Targets set by the Brain Trauma Foundation @brain_trauma and the results of the #BEST-TRIP trial are noted. b) The cost-effectiveness of #tranexamicacid per 2 nations are compared. c) Clinical pearls and caveats are listed.d) Evidence-based clinical recommendations are
1
0
0
6/10 Emergency neurosurgical techniques include #cisternostomy, an adjunct to decompressive #craniectomy to reduce #ICP, and potentially reduce #edema via #glymphatic system, with promising outcomes in early, small studies. 🧵
1
0
1
5/10 Neurosurgical management is required in ~13% of hospitalized patients with #TBI for 3 major indications: a) Acute #SDHremoval; b) Mass effect with Neurological Decline; c) Refractory rise in #ICP. The optimal window for most neurosurgical interventions is 6-24 hours. The
1
0
0
4/10 Key takeaways are:.1. FDA- approved biomarkers include #GFAP and #UCH-L1 (#Ubiquitin);.2. High sensitivity (97%) but low specificity (19%);.3. Rapid screening reduces unnecessary CT scans;.4. Biomarkers correlate with functional outcomes 🧵
1
0
0
3/10 At Penn, he has worked with the Center for Surgical Health (@surgical_health) and United Community Clinic, providing access to medical and surgical care for the underserved West Philly community. He works with Dr. Jake Brenner, MD, PhD @jakebrenner to optimize.
1
0
0
2/10 Harry Dang is a 2nd year Penn MD-PhD student at the Perelman School of Medicine who hails from @City_of_Irvine and hopes to pursue a surgical specialty, embracing his research interests including targeted #drugdelivery, #biomaterials, and #immunotherapy. @urichmond, he
1
0
0
1/10 Kudos to Harry Dang who completed his capstone project, "Traumatic Brain Injury: Evidence-Based Management with Focus on the #CRASH-3 Trial" @PennNSG @pennsurgery @PennCancer @PennMedCSO 🧵.
1
0
5
8/10 a)Targets set by the Brain Trauma Foundation @brain_trauma and the results of the #BEST-TRIP trial are noted. b) The cost-effectiveness of #tranexamic acid per 2 nations are compared. c) Clinical pearls and caveats are listed.d) Evidence-based clinical recommendations are
0
0
1
6/10 Emergency neurosurgical techniques include #cisternostomy, an adjunct to decompressive #craniectomy to reduce #ICP, and potentially reduce #edema via glymphatic system, with promising outcomes in early, small studies. 🧵
1
0
0
4/10 Key takeaways are: .1. FDA- approved biomarkers include #GFAP and #UCH-L1 (#Ubiquitin);. 2. There is a high sensitivity (97%) but low specificity (19%);. 3. Rapid screening reduces unnecessary CT scans;. 4. Biomarkers correlate with functional outcomes 🧵
1
0
0
3/10 At Penn, he has worked with the Center for Surgical Health (@surgical_health ) and United Community Clinic, providing access to medical and surgical care for the underserved West Philly community. He works with Dr. Jake Brenner, MD, PhD @jakebrenner to optimize.
1
0
0
RT @PennNSG: Last night we celebrated Drs. @sm_hemanackah, @mariapunchak_md, and Connor Wathen, MD for graduating from our residency progra….
0
5
0
5/5 What is the pathophysiology of coma in this patient? @DanielAlaiev suspects it is the thalamic arousal pathways (Saper et al, 2005). DTI imaging can reveal structural degradation of WM Tracts (Uh 2021). Jin (2024) noted abnormal FC within the hypothalamus-DMN circuit.
1
0
3
3/5 A patient with a large #craniopharyngioma presented with loss of consciousness, and the tumor was skillfully removed by @DrLeeBrainSurg using advanced endoscopic techniques. 🧵
1
0
3