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Steven Brem Profile
Steven Brem

@StevenBremMD

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Professor of Neurosurgery at the University of Pennsylvania, neurosurgeon, scientist, innovator, advancing clinical trials to meet unmet needs in neuro-oncology

Joined December 2016
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@StevenBremMD
Steven Brem
6 months
Excited to work with @NdukaAmankulor to announce the 12th Penn Brain Tumor CME on 1.31.2025. Keynotes by Ganesh Rao, MD @DoctorGRao on #LITT - From Laboratory to Clinical Applications, and Ingo K. Mellinghoff, MD, FACP, on the #INDIGO Trial: Paradigm changes for #IDHmutant
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@StevenBremMD
Steven Brem
12 days
10/10 For a comprehensive summary of Best Practice Guidelines for #braininjury, see the @AmCollSurgeons publication best-practices-guidelines-traumatic-brain-injury.pdf
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@StevenBremMD
Steven Brem
12 days
9/10 Future directions in the management of #TBI and innovative approaches are described, including current clinical trials using #erythropoietin (neuroprotection); #N-acetylcysteine (antioxidant); c) #amantadine (cognitive function). 🧵
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@StevenBremMD
Steven Brem
12 days
8/10 a)Targets set by the Brain Trauma Foundation @brain_trauma and the results of the #BEST-TRIP trial are noted. b) The cost-effectiveness of #tranexamicacid per 2 nations are compared. c) Clinical pearls and caveats are listed.d) Evidence-based clinical recommendations are
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@StevenBremMD
Steven Brem
12 days
7/10 ICP Monitoring Techniques include: .a) Intraventricular catheter (gold standard); .b) Subdural bolt;. c) Epidural sensor 🧵
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@StevenBremMD
Steven Brem
12 days
6/10 Emergency neurosurgical techniques include #cisternostomy, an adjunct to decompressive #craniectomy to reduce #ICP, and potentially reduce #edema via #glymphatic system, with promising outcomes in early, small studies. 🧵
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@StevenBremMD
Steven Brem
12 days
5/10 Neurosurgical management is required in ~13% of hospitalized patients with #TBI for 3 major indications: a) Acute #SDHremoval; b) Mass effect with Neurological Decline; c) Refractory rise in #ICP. The optimal window for most neurosurgical interventions is 6-24 hours. The
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@StevenBremMD
Steven Brem
12 days
4/10 Key takeaways are:.1. FDA- approved biomarkers include #GFAP and #UCH-L1 (#Ubiquitin);.2. High sensitivity (97%) but low specificity (19%);.3. Rapid screening reduces unnecessary CT scans;.4. Biomarkers correlate with functional outcomes 🧵
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@StevenBremMD
Steven Brem
12 days
3/10 At Penn, he has worked with the Center for Surgical Health (@surgical_health) and United Community Clinic, providing access to medical and surgical care for the underserved West Philly community. He works with Dr. Jake Brenner, MD, PhD @jakebrenner to optimize.
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@StevenBremMD
Steven Brem
12 days
2/10 Harry Dang is a 2nd year Penn MD-PhD student at the Perelman School of Medicine who hails from @City_of_Irvine and hopes to pursue a surgical specialty, embracing his research interests including targeted #drugdelivery, #biomaterials, and #immunotherapy. @urichmond, he
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@StevenBremMD
Steven Brem
12 days
1/10 Kudos to Harry Dang who completed his capstone project, "Traumatic Brain Injury: Evidence-Based Management with Focus on the #CRASH-3 Trial" @PennNSG @pennsurgery @PennCancer @PennMedCSO 🧵.
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@StevenBremMD
Steven Brem
13 days
8/10 a)Targets set by the Brain Trauma Foundation @brain_trauma and the results of the #BEST-TRIP trial are noted. b) The cost-effectiveness of #tranexamic acid per 2 nations are compared. c) Clinical pearls and caveats are listed.d) Evidence-based clinical recommendations are
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@StevenBremMD
Steven Brem
13 days
7/10 ICP Monitoring Techniques include: a) Intraventricular catheter (gold standard); b) Subdural bolt; c) Epidural sensor🧵
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@StevenBremMD
Steven Brem
13 days
6/10 Emergency neurosurgical techniques include #cisternostomy, an adjunct to decompressive #craniectomy to reduce #ICP, and potentially reduce #edema via glymphatic system, with promising outcomes in early, small studies. 🧵
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@StevenBremMD
Steven Brem
13 days
5/10 Neurosurgical management is required in ~13% of hospitalized patients with #TBI for 3 major indications: a) Acute #SDH removal; b) Mass effect with Neurological Decline; c) Refractory rise in #ICP. The optimal window for most neurosurgical interventions is 6-24 hours. The
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@StevenBremMD
Steven Brem
13 days
4/10 Key takeaways are: .1. FDA- approved biomarkers include #GFAP and #UCH-L1 (#Ubiquitin);. 2. There is a high sensitivity (97%) but low specificity (19%);. 3. Rapid screening reduces unnecessary CT scans;. 4. Biomarkers correlate with functional outcomes 🧵
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@StevenBremMD
Steven Brem
13 days
3/10 At Penn, he has worked with the Center for Surgical Health (@surgical_health ) and United Community Clinic, providing access to medical and surgical care for the underserved West Philly community. He works with Dr. Jake Brenner, MD, PhD @jakebrenner to optimize.
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@StevenBremMD
Steven Brem
13 days
RT @PennNSG: Last night we celebrated Drs. @sm_hemanackah, @mariapunchak_md, and Connor Wathen, MD for graduating from our residency progra….
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@StevenBremMD
Steven Brem
14 days
5/5 What is the pathophysiology of coma in this patient? @DanielAlaiev suspects it is the thalamic arousal pathways (Saper et al, 2005). DTI imaging can reveal structural degradation of WM Tracts (Uh 2021). Jin (2024) noted abnormal FC within the hypothalamus-DMN circuit.
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@StevenBremMD
Steven Brem
14 days
4/5 The 6 key steps in the operation by @DrLeeBrainSurg are summarized
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@StevenBremMD
Steven Brem
14 days
3/5 A patient with a large #craniopharyngioma presented with loss of consciousness, and the tumor was skillfully removed by @DrLeeBrainSurg using advanced endoscopic techniques. 🧵
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