Thank you @StemCellNetwork for the continued support of our research towards biological pacemakers!. We are currently hiring a postdoc to lead the project - come join us!

Thank you @UHN_Research for highlighting our paper.

and last but not least not least, thanks to all our funding sources @StemCellNetwork, @CIHR_IRSC, @InnovationCA, @BlueRockTx.

And thanks to all our collaborators – we could not have done it without you!.@DelaramPB , @MishAshraf , @katehuang_, Faisal Alibhai, Thinh Thran, @AmineMazineMD, @garybader1 , @LaksmanResearch @LaflammeMichael.

Congratulations to the amazing team of graduate students who made it happen.Amos Lim, @michellecells , @bmurareanu, @matthewlkchang from.@McEwenInstitute @MoGen_Grad @UHN_Research @UHN.

Access to a SAN specific surface marker will advance SAN specific disease modelling, targeted in vivo drug delivery, and the development of biological pacemakers. #biologicalpacemaker #BioPM #regmed.

CD34 specifically labels SAN pacemaker cardiomyocytes in human SAN tissue and SANLPC cultures. Sorting for CD34+ cells from human pluripotent stem cell differentiation cultures enriches for SANLPCs with a functional pacemaker phenotype.

We show that the developing SAN consists of three subtypes of pacemaker cells: Core Pacemaker, Sinus Venosus, and Transitional Cells. Human pluripotent stem cell-derived SANLPC cultures contain the same subset of pacemaker cells and closely resemble fetal SAN pacemaker cells.

We performed single nuclei transcriptome analysis of the human SAN to get a better understanding of its cellular and molecular composition and identified multiple SAN specific markers including MYH11, BMP4 and CD34.

So excited to share the first paper from the lab!.We identified CD34 as a marker of the heart’s SAN pacemaker cells enabling their isolation from stem cell differentiation cultures, advancing future disease modeling and biological pacemaker applications.

Congrats to @michellecells for winning the oral presentation award at #TMM2024 @McEwenInstitute @StemCellNetwork - so well deserved! #proudpi.

Thanks @StemCellNetwork for letting me organize the session - was lots of fun connecting with the speakers.

RT @StemCellNetwork: (2/2) Thanks to Wolfram Zimmerman, Nicole Dittman, @Yassi_ag, and @chang_natasha for their insightful presentations, c….

Great talk by @michellecells on hPSC-derived AVNLPc and efforts to develop a biological conduction bridge. We are looking to move this project into a preclinical pig model and recruiting a pdf leading this work. DM if interested #tmm2024 @McEwenInstitute

Had a great time taking a short break from mat leave and catching up with our collaborators from the @Professeltine lab about our ARVC5 project while they were in town for #TMM2023 @StemCellNetwork

RT @StemCellNetwork: Dr. Michael Rudnicki recognizes Dr. Gordon Keller as the recipient of the 2023 Till & McCulloch Award for his exceptio….

RT @HHMIJanelia: 📢 We’re #hiring! . Are you ready to lead a lab? We’re recruiting early career scientists for Group Leader positions acros….

RT @UHN_Research: A group of @UHN researchers led by Dr. @AnnaRGagliardi set out to redefine research assessment practices at UHN based on….

Exciting addition of my favourite cells - pacemaker and conduction system cells to the human heart cell atlas @humancellatlas by @JamesCranley and @kazukane from the Teichmann lab and collaborators!.

RT @tinyglue: #Glia2023 if you were inspired by stories you heard during this amazing meeting, and want to work with human iPSC-derived (mi….