Spring Group
@SpringGroupChem
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ADCs, peptides, small molecule drugs and degraders. Student run account @ChemCambridge @Cambridge_Uni.
Cambridge
Joined March 2013
Amazing and elegant work!.
We are excited to share our new work on one carbon alkene homologation. We can iteratively homologate terminal and internal alkenes in simple and complex molecules using this method. Great work by Marcus that opens up lots of exciting opportunities for us.
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Congratulations to our very own first-year student Georgie Bonney for winning the poster prize today at @AstraZeneca student symposium in Cambridge!
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A Platform for SpyCatcher Conjugation to Native Antibodies.Out now in @ChemicalScience .
pubs.rsc.org
Protein–antibody conjugates represent major advancements in targeted therapeutics. However, platforms enabling ‘off-the-shelf’ antibody conjugation are seldom reported. The SpyTag/SpyCatcher system,...
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Check out our newest paper in @ChemEurJ: Advances in the Release of Amide-Containing Molecules!.
chemistry-europe.onlinelibrary.wiley.com
The ability to release a molecule from a larger construct in a controlled manner is of great importance to produce effective prodrugs, antibody-drug conjugates, and chemical probes. Amides are...
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A great read!.
#RachelBrazil examines progress by researchers to create a new generation of antibody drug conjugates to improve efficacy and minimise off-target adverse effects of these cancer therapies.#Enhertu #enfortumabvedotin #antibodydrugconjugate .
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RT @RSC_PPSG: Happy New Year to all of our followers!🎇. Join us for our next webinar on Protein and Peptide Science on 7th February 1pm UK….
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RT @ProfDaveLeigh: Very sad news of the passing of @sirfrasersays, a giant of chemistry for four decades. He pioneered (with J-P Sauvage) t….
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#SpringleMingle’s in Action: Congratulations to Saan Voss (@peptidestudio) for bringing home the 1st Luis Moroder award for the best conference presentation at the 18th peptide workshop in Naples!
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It's also time that we welcome new PhD students Aryaman, Georgie, Sophie and Josh to the group! We've loved having you thus far and can't wait to see the amazing science you get up to over the next 3/4 years.
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A wonderful group away day @TrinCollCam filled with excellent science, great food and lovely chat. A big thank you to Sarah and Daria for organising!
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RT @MatthewGaunt8: The @Gaunt_Group are looking for two enthusiastic and talented researchers to join our dynamic team in Cambridge, as pos….
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RT @MatthewGaunt8: Amazing paper from the group of my Cambridge colleague Robert Phipps. Great work.
science.org
Hydrogen atom abstraction is an important elementary chemical process but is very difficult to carry out enantioselectively. We have developed catalysts, readily derived from the Cinchona alkaloid...
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RT @GroupWebster: PhD studentship available in the group with @AstraZeneca in iron catalysis! Another inorganic catalysis PhD is also avail….
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RT @MatthewGaunt8: Come and join our team. We have an exciting Synthetic Chemistry PhD opportunity in the @Gaunt_Group (starting Oct 2025)….
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RT @MahriPark: Very excited to see this work published! A huge thank you to our colleagues and collaborators, without whom this would not h….
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RT @ESBOC_Gregynog: Thomas Wharton on self-immolative release of amine-containing drugs. Check out his recent paper:. .
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RT @angew_chem: The list of most-accessed papers in the past month includes contributions by @MaulideLab, @springgroupchem, @ICIQchem, @sum….
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RT @angew_chem: Unlocking Amides: A General Method for the Self-Immolative Release of Amide-Containing Molecules (David R. Spring) @springg….
onlinelibrary.wiley.com
Methodologies for the self-immolative release of amide motifs remain scarce despite the prevalence of amides in molecules. Herein, is presented a general and comprehensive strategy for the selective...
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Make sure to check out Spring group presentations / posters at #ACSspring2024 tomorrow, Sunday 17th of March👇. 🕙10:00 - 10:20 am - Jack Sydenham (oral presentation).🕒2:50 - 3:15 pm - @call_me_sonja (oral presentation).🕖7:00 - 9:00 pm - @SophidayR (poster presentation #1724).
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