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Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ Profile
Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ

@SposatoL

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Stroke Neurologist โ€ข ๐—›๐—ฒ๐—ฎ๐—ฑ Stroke Program @WesternU โ€ข ๐—ฆ๐—ฒ๐—ฐ๐˜๐—ถ๐—ผ๐—ป ๐—˜๐—ฑ๐—ถ๐˜๐—ผ๐—ฟ Neurocardiology @StrokeAHA_ASA โ€ข ๐—–๐—ต๐—ฎ๐—ถ๐—ฟ @WorldStrokeOrg H&B TaskForce

London, Ontario
Joined February 2009
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@SposatoL
Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
3 months
What if I told you it is possible to increase 6โƒฃ times the detection of cardioaortic thrombi in stroke patients with a simple tweak to your current workflow?.๐Ÿคฏ๐Ÿคฏ๐Ÿคฏ.We would only need to screen 1โƒฃ4โƒฃ patients to find 1โƒฃ thrombus! Curious? Read on! DAYLIGHT Trial.
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@SposatoL
Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
9 hours
RT @J_Rosales_MD: ๐Ÿง ๐Ÿฉธ Survey of 580 clinicians in LATAM.countries: .๐Ÿ‘‰๐Ÿปonly 28% have an ICH code ๐Ÿฅ๐Ÿ“‹.๐Ÿ‘‰๐ŸปINTERACT3 care bundle adherence rangesโ€ฆ.
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@grok
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@SposatoL
Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
3 days
RT @ShadiYaghi2: Meet us at #WSC25 in Barcelona in October & attend a terrific program of cutting edge research. Also find out the final reโ€ฆ.
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@SposatoL
Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
4 days
RT @MicheleRomoli: Atrial fibrillation patients can still suffer a stoke while on DOACs. ๐’๐ก๐จ๐ฎ๐ฅ๐ ๐ฐ๐ž ๐ฌ๐ฐ๐ข๐ญ๐œ๐ก ๐ญ๐จ VKA, ๐ญ๐ซ๐ฒ ๐š ๐๐ข๐Ÿ๐Ÿ๐ž๐ซ๐ž๐ง๐ญ ๐ƒ๐Ž๐€๐‚, ๐จ๐ซโ€ฆ.
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neurology.org
Background and ObjectivesThe management of anticoagulation after ischemic stroke while on direct oral anticoagulants (DOACs) is controversial. We performed an aggregate-data meta-analysis to compare...
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@SposatoL
Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
4 days
RT @MicheleRomoli: Kudos to all Stroke Researchers dedicated to neurovascular diseases that participated in this study @carlomictusvh @Ziniโ€ฆ.
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neurology.org
Background and ObjectivesThe management of anticoagulation after ischemic stroke while on direct oral anticoagulants (DOACs) is controversial. We performed an aggregate-data meta-analysis to compare...
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@SposatoL
Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
4 days
RT @WorldStrokeOrg: ESUS isnโ€™t one disease. Join global experts at #WSC2025 as they crack the diagnostic code through thrombi histopathologโ€ฆ.
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@SposatoL
Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
29 days
๐Ÿง  Great paper on BNP and timing of AFDAS diagnosis. ๐Ÿ”–Ref 1. ๐Ÿ“Œ 374 #stroke pt w/o known #Afib, but AFDAS detected on cardiac monitoring (BIOSIGNAL & GRAZ cohorts). ๐Ÿ“‰ Inhospital AFDAS (72%):.๐Ÿงช NT-proBNP at admission predicts in-hospital AFDAS . โ–ช๏ธCutoff: 505 pg/mL โ†’ AUC 0.83
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@SposatoL
Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
29 days
RT @CAlejandroneuro: Nuestra Red y Centro de ACV @SubRedNorte tendrรก este mes en la tradicional reuniรณn mensual un gran colega y amigo comoโ€ฆ.
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Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
1 month
RT @J_Rosales_MD: @SposatoL Extremely high AIS recurrence !.Agree with Dr Hawkes
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Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
1 month
๐Ÿง  PFO Closure in Ischemic Stroke & TIA Patients โ‰ฅ60y.๐Ÿ”— ๐Ÿ“Œ Single-center cohort, n=239.๐Ÿ‘ด 120 patients โ‰ฅ60y.โฑ 3.1y mean follow-up. ๐ŸŽฏ Recurrent stroke rates.โ–ช๏ธPFO closure (โ‰ฅ60y): 6.1% (3/49).โ–ช๏ธNo closure (โ‰ฅ60y): 25.4% (18/71).๐Ÿ“‰ aHR = 0.11 (95% CI:.
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@SposatoL
Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
1 month
๐Ÿง  IV Thrombolysis in CADASIL: Safe & Effective?. Two retrospective cohort studies below๐Ÿ‘‡. ๐Ÿ“Œ STUDY 1.๐Ÿฅ 609 CADASIL patients (Taiwan, Japan, Korea), 204 with IS.๐Ÿ“Š Median age of 60y, 5 microbleeds, NIHSS 5. Small subcortical infarcts.๐Ÿ’‰ 12 (5%) received IVT, 4 with low dose.
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@SposatoL
Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
1 month
In case you missed it: ๐Ÿ™ SANCTUARY SITES . โœ… Background. Infarction probability (Pi) maps highlight vulnerable brain regions post-stroke (basal ganglia), but they could also be used for identifying infarction-resistant areas. ๐Ÿง  Population. 154 patients with isolated or
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Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
1 month
Nice paper by @Dr_No_Charite @Jan_FriSch et al. from .@BerlinStroke @ChariteBerlin . โœ… Background. Troponin elevation is common post-stroke, but mechanisms remain unclear. ๐Ÿง  Population. 508 ischemic stroke patients with serial hs-cTnT in 1st 48h.โ€“ 254 with acute myocardial.
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@SposatoL
Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
1 month
Thoughts:.- Great work! Large, real-world cohort (n=1795). - Both ischemic and hemorrhagic recurrences are qualifying events and part of the โ€œearly stroke recurrenceโ€ outcome. - No data on AF detection method (ECG vs. monitoring), so AF burden and mechanism are unclear. -.
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Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
1 month
New interesting analysis of early stroke recurrence in patients with AF:.- Qualifying events: 1795 first ischemic (91%) or hemorrhagic (8%) strokes between 20204 and 2025. - AF either known or detected within 6โ€‰months. Findings:.- High CHA2DS2-VASc score, concomitant etiologies,
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@SposatoL
Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
2 months
RT @LHSCRI: A clinical trial led by LHSCRI and Western Universityโ€™s @SchulichMedDent has helped improve the detection of hidden blood clotsโ€ฆ.
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@SposatoL
Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
3 months
SURPRISE.Open access to the paper until July 8, 2025: Thanks to the great @WesternU @westernuCNS @SchulichMedDent @LHSCCanada Team @RodrigoBagur @DianaAyan77 @friseb @SACHINKISHORE82 @DebickiDerek @casserly_dr .8/8
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@SposatoL
Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
3 months
CONCLUSIONS.1โƒฃ A non-gated, single-phase, extended CTA can increase the detection of cardioaortic.thrombi by 6-fold with an NNS of 14.2โƒฃ It only causes a minimal excess of radiation, does not require additional contrast, and does not delay acute treatment. 3โƒฃ Its impact on stroke.
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@SposatoL
Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
3 months
LIMITATIONS.๐Ÿ›‘Some thrombi were not confirmed with dedicated cardiac imaging. ๐ŸŸขPre-specified criteria were used to account for this expected limitation. ๐Ÿ›‘70% of patients with a thrombus had #AtrialFibrillation. ๐ŸŸขStroke physicians believe finding a thrombus is still clinically
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@SposatoL
Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
3 months
SAFETY OUTCOMES.โŒ›๏ธNo differences in time to completion of CTA, door-to-needle time, or door-to-groin puncture time. โ˜ข๏ธSlightly increased radiation exposure with extended CTA use: median of 1 mSv, equivalent to 2.5 mammograms. 5/8
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@SposatoL
Luciano Sposato ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ
3 months
EFFICACY OUTCOMES.Cardioaortic thrombi detection (primary efficacy endpoint) was 6-fold higher by applying an extended CTA compared to standard of care CTA:.๐ŸŽฏ8.8% in the extended CT angiography group vs. 1.7% in the standard CT angiography group. ๐ŸŽฏOR 5.70, 95% CI 1.92โ€“16.96;
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