SosaLab
@SosaLab4
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Structure & function of biological molecular machines
Bronx, NY
Joined May 2020
New insights into the mechanochemical coupling mechanism of kinesin–microtubule complexes from their high-resolution structures https://t.co/nLghpzVsZp
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Congrats @arnegennerich and all, this is a huge breakthrough to have such detailed structures of KIF1A bound to microtubules! Very important work. Thank you from all our families and the whole community.
The Sosa and Gennerich Labs report the fist near-atomic structures of KIF1A bound to microtubules.
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High-Resolution structures of microtubule-bound KIF1A and its pathogenic variant P305L
biorxiv.org
Mutations in the Kinesin-3 motor KIF1A, a microtubule (MT)-associated motor protein, cause devastating neurodevelopmental and neurodegenerative diseases termed KIF1A-associated neurological disorders...
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Nucleotide-free structures of Kif20A illuminate the atypical allostery in this mitotic kinesin-6
biorxiv.org
KIF20A is a critical kinesin for cell division and a promising anti-cancer drug target. The mechanisms underlying its cellular roles remain elusive. Interestingly, unusual coupling between the...
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Our recent work in collaboration with the Allingham's lab describing the mechanism of combined motile and depolymerization activities by a kinesin-8 just came out!
nature.com
Nature Communications - Kinesin-8s are dual-activity motor proteins that can move processively on microtubules and depolymerize microtubule plus-ends. This study shows how kinesin-8s alternate...
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Our latest preprint on the Kinesin-8 combined motile & microtubule depolymerization mechanism https://t.co/0c4CvxtJRv
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https://t.co/PB7YlPOV5b Just out! Significant additions to the preprint https://t.co/f1VEivL9E1 are the separation of coexisting motor-head conformations and improved resolution (2.7-3.9 Å now). @matthieuBenoit1 @HernandoSosa4 @SEMC_NYSBC @cryoEM_Papers #microtubule #kinesin
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Glad to see our paper finally coming out with 18 cryo-EM snapshosts of the molecular motor KIF14. https://t.co/6kRDpN0Xrz
biorxiv.org
KIF14 is a mitotic kinesin protein important for cytokinesis. Its overexpression is associated with a variety of cancers and mutations in KIF14 result in cerebral and renal development defects. Like...
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18 new #cryoEM structures of the kinesin molecular motor KIF14 reveal its translocation mechanism @SosaLab4
https://t.co/8PqO24fMsc Collaboration with Kwok lab. Data collected at @SEMC_NYSBC
#EinsteinMed #MTmotors #kinesins #microtubules #biophysics @cryoEM_Papers #cellbiology
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Sosa lab @EinsteinMed provides structural insights into kinesin-13 mediated microtubule depolymerisation. https://t.co/oNVhXvPc8S
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