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Snoeck Lab Profile
Snoeck Lab

@SnoeckLab

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Laboratory of Hans-Willem Snoeck @Columbia focusing on Stem Cells, from the basic to the translational email: [email protected]

New York, New York
Joined September 2023
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@SnoeckLab
Snoeck Lab
4 months
RT @stemcellpodcast: Dr. Mikael Pezet, Juan Torres, and a team in the @SnoeckLab developed an hPSC-derived model for #PulmonaryFibrosis! 🫁….
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@SnoeckLab
Snoeck Lab
4 months
We are excited to continue using this platform for future drug discovery and to find treatments for IPF.
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@SnoeckLab
Snoeck Lab
4 months
Intriguingly, iRAPs carrying a mutation in Hermansky Pudlak Syndrome 1 (HPS1), a highly penetrant mutation associated with IPF, showed impaired differentiation and recruited fibroblasts in co-culture, suggesting a direct link between RAPs and pulmonary fibrosis.
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@SnoeckLab
Snoeck Lab
4 months
We show that iRAPs can be differentiated towards a transitional AT2-like cell and finally towards a mature AT1-like cell, showing an in vitro differentiation pathway from RAP to mature distal lung cell type.
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@SnoeckLab
Snoeck Lab
4 months
We are excited to share our work out this week in Nature Biotechnology. We generate from pluripotent stem cells induced respiratory airways progenitors (iRAPs), a novel cell type that is increasingly being appreciated for its ability to regenerate the distal lung.
@NatureBiotech
Nature Biotechnology
5 months
Human respiratory airway progenitors derived from pluripotent cells generate alveolar epithelial cells and model pulmonary fibrosis
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@SnoeckLab
Snoeck Lab
1 year
We also reveal that replication stress and DNA damage in HSCs are at least in part due to uracil misincorporation, and are a barrier to HSC maintenance in vitro.
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@SnoeckLab
Snoeck Lab
1 year
Induction of G2 arrest may be a novel strategy to generate megakaryocytes and platelets from HSCs.
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@SnoeckLab
Snoeck Lab
1 year
We are proud to share the collaborative work of our graduate student, Corey Garyn, and post-doc, Oriol Bover. They show that G2 arrest, which is caused by DNA damage, induces megakaryocyte (MK) priming in hematopoietic stem cells (HSCs).
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@SnoeckLab
Snoeck Lab
1 year
This is a cutting-edge and novel technique, pleasure collaborating with your amazing team.
@GaublommeL
Gaublomme Laboratory
1 year
Update: for those interested in optical pooled screening in stem/pluripotent cells and neurons, we tested CRISPRmap in hESCs, iPSCs and iPSC derived neurons, and observed good barcode recovery. Shout out to the Wichterle lab and @SnoeckLab for their help in these cell contexts.
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@SnoeckLab
Snoeck Lab
2 years
Happy birthday to our very own Tania Thimraj and Carolina Petrillo 🎂🥳
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@SnoeckLab
Snoeck Lab
2 years
Hsiao-Yun Mavis at #NYSCF2023 presenting her incredible work on lung engraftment! A great conclusion to day 1 of the conference.
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@SnoeckLab
Snoeck Lab
2 years
A wonderful time at #NYSCF23. Mikael Pezet from the lung team presenting a poster on his work studying lung differentiation and disease modeling @nyscf
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@SnoeckLab
Snoeck Lab
2 years
Finally, meet the PI, Hans-Willem Snoeck, MD, PhD. Originally from Belgium🇧🇪, he has been at Columbia for 10+ years and is the biggest supporter of all lab projects. See below for more details about lab members, their projects, and follow for updates 🫁🩸
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@SnoeckLab
Snoeck Lab
2 years
She studies the function of mitochondrial dynamics in hematopoiesis.
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@SnoeckLab
Snoeck Lab
2 years
Meet Yan Yao, a post doc on the blood side of the Snoeck Lab. Originally from China 🇨🇳, she joined the lab in 2019.
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@SnoeckLab
Snoeck Lab
2 years
Her project aims to investigate how mitochondria, the powerhouses of cells, appear able to dampen the effects of age and age-related malignancies on blood stem cells.
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@SnoeckLab
Snoeck Lab
2 years
Meet Carolina Petrillo, a post doc on the blood side of the Snoeck Lab. Originally from Italy🇮🇹, she completed her PhD in Italy before joining the lab in 2019.
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@SnoeckLab
Snoeck Lab
2 years
Her project involves using fibrotic lung organoid models as a tool for drug discovery and testing. She also analyzes genomics data with a focus on scRNA sequencing to better decode our lung organoid models.
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@SnoeckLab
Snoeck Lab
2 years
Meet Tania Ahalya Thimraj, a post doc on the lung side of the Snoeck Lab. Originally from India 🇮🇳, she completed her PhD in India before joining the lab in 2019.
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@SnoeckLab
Snoeck Lab
2 years
His project focuses on how mutations that cause fibrotic lung diseases result in defects in regeneration and impaired stress response.
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