Shukla Group
@ShuklaGroup
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Research Group @ChBE_Illinois, @Illinois_Alma
Urbana, IL
Joined June 2015
RT @MichaelCJewett: How can we use biological datasets to accelerate design for synthetic biology applications? We developed an ML-driven,….
biorxiv.org
Point-of-use diagnostics based on allosteric transcription factors (aTFs) are promising tools for environmental monitoring and human health. However, biosensors relying on natural aTFs rarely exhibit...
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RT @ChBEIllinois: With a new five-year, $15M award, the @NSF has renewed its support of the @Molecule_Maker Lab Institute, which develops A….
chbe.illinois.edu
NSF reinvests in Molecule Maker Lab Institute, AI tools to solve chemistry’s challenges
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RT @BiologyAIDaily: Two for the Price of One: Integrating Large Language Models to Learn Biophysical Interactions . 1. This study presents….
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RT @ChBEIllinois: Congratulations to professors Guironnet, Rogers and Shukla who have been named James W. Westwater professorial scholars i….
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RT @sushmajumdarlab: A cannabinoid bitopic, biased and peripheral agonist analgesic with limited tolerance and tetrad in Nature. Work led b….
nature.com
Nature - A peripherally restricted CB1 agonist (VIP36) targeting a cryptic receptor pocket was developed, showing high efficacy in mouse pain models with minimal side effects and tolerance,...
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RT @KeikoUTorii: Love the beautiful illustration🥰! Our work published @ScienceAdvances , featured by Daily Texan News! 私達の最新の研究成果がローカル大学新聞に….
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RT @ChBEIllinois: Congratulations to CHBE Professor Ying Diao, one of three Illinois researchers who have received Presidential Early Caree….
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RT @CommsChem: .@shuklagroup & @diwakarshukla and colleagues report the transport mechanism of an alanine-alanine peptide through the PepTS….
nature.com
Communications Chemistry - The PepTSo transporter mediates the transport of peptides across biological membranes, however, the molecular basis of peptide recognition and transport by PepTSo is not...
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Congratulations to Joseph Clark, undergraduate researcher in our lab and his mentor, Xuenan Mi for publication of their paper on peptide language model, PeptideESM! @MCB_Illinois @diwakarshukla.
In our latest featured article, Clark, Shukla et al. show that masked language model development for the prediction of RiPP substrates creates models that are transferable between enzymes which act within the same pathway. Read the #openaccess paper:
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Congratulations to the newest doctor from our group, Dr. Xuenan Mi! She will join @JNJNews as a research scientist in January! @ChBEIllinois @diwakarshukla
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RT @agr_chemistry: It was our pleasure (@SwansonGroup_UT) to highlight the latest on lasso peptide folding and substrate–cyclase tolerance….
nature.com
Nature Chemical Biology - Lasso peptides are naturally produced interlocked molecules that hold promise for the design of stable peptide-based therapeutics. Recent predictions of...
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Congratulations to Prateek Bansal @thepdbguy for winning the ACS PRIDE Merck Graduate Research Award from American Chemical Society! @AmerChemSociety @ChBEIllinois @LASillinois
chbe.illinois.edu
Bansal receives ACS Pride Merck Graduate Research Award
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RT @BiologyAIDaily: LassoESM: A Tailored Language Model for Enhanced Lasso Peptide Property Prediction. • LassoESM is a specialized protein….
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Thanks to @DrTracyLawson & @leakey77 for leading the ASAP center, and @NSF for funding our research on plant synthetic biology!.
.@DrTracyLawson & @leakey77 will lead the Alliance for Socially-acceptable & Actionable Plants (ASAP), a new @NSF-funded global center that will work to provide synthetic biology solutions for high-energy, water-use-efficient crops. Read more here:
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Congratulations to Susanna @SusannaBar2 from Mitchell group @ChemistryUIUC and Song from @ShuklaGroup @ChBEIllinois for their work on understanding how enzymes tie the lasso knot in peptides published in Nature Chemical Biology @nchembio!.
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Congratulations to Xuenan Mi for winning the Graduate student excellence award from @ACSCOMP #ACSFall2024! You can read more about it here: .
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Congratulations to Hassan Nadeem, graduate student @BIOENGatIL for receiving the Mavis future faculty fellowship from the college of engineering! @uofigrainge
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Farewell to summer interns, Arkajyoti Bannerjee from @iacskolkata and Sayan Patra from @iitbombay! Thanks to the Indo-U.S. Science & Technology Forum @INDOUSSTF for supporting their work as Khorana Scholars in our group!
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RT @ShabekLab: 🎉Excited to share yet another story from our lab, now @NatureComms revealing how the phytohormone Strigolactone is deactiva….
nature.com
Nature Communications - Plant hormone levels are regulated by synthesis and breakdown, but the mechanism of strigolactone degradation remains unclear. This study reveals the structure of distinct...
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