Shmuel Shoham
@ShohamTxID
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Working on therapies for prevention and treatment of coronavirus. Transplant Infectious Diseases physician at Johns Hopkins. @[email protected]
Baltimore, MD
Joined May 2015
At our best infectious diseases experts can act as the synapses that connect surgeons, internists, pharmacists, microbiologists, epidemiologists and the patients to make good decisions.
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Triazole-resistant Aspergillus fumigatus in the Netherlands between 1994 and 2022: a genomic and phenotypic study - The Lancet Microbe
thelancet.com
Our study showed variation in triazole genotypes and phenotypes in clinical A fumigatus isolates with cyp51A-mediated resistance, some of which were cultured from triazole-resistant invasive asperg...
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Two Pandemics, Compared: Reflections on HIV and COVID-19
blogs.jwatch.org
“Dr. Sax, what’s it like to have lived through two pandemics as an ID doctor?” The question came from a brand-new intern during afternoon sign-out. I took a breath — because wow, were they different....
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A great opportunity for those wanting to learn and update themselves about infections in transplant and oncology patients.
https://t.co/fU185EbXpB We are excited about this course. We are sure @Contagion_Live readers will find this course worthwhile
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https://t.co/fU185EbXpB We are excited about this course. We are sure @Contagion_Live readers will find this course worthwhile
hopkinsmedicine.org
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Aspergillus tanneri fast facts: Tends to be resistant to multiple antifungal agents, described in people with chronic granulomatous disease (CGD) Western parts of US, living in Western parts of the US. Disseminated and contiguous disease patterns
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Clinical situation: should you use vancomycin as part of empiric therapy in patient with AML and pneumonia. Answer from clinical trial: Not typically, if MRSA screen is negative - Talagtag - 2021 - Transplant Infectious Disease - Wiley Online Library
onlinelibrary.wiley.com
Background Current literature has demonstrated the utility of the MRSA nasal screen as a de-escalation tool to decrease unnecessary anti-MRSA antibiotic therapy. However, data on the applicability...
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Candida auris: a) adheres to skin and inanimate objects, b) colonization often clinically significant (compared to C. albicans), c) associated with outbreaks, d) often resistant to fluconazole, and sometimes echinocandins too. A good review article by Lionakis in NEJM in 2024
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Teaching case: middle aged man with ulcerative colitis. Disease has been stable, but now seemingly flares. CMV viral load ~100K. Endoscopy: CMV colitis. CMV IgG had been negative previously. Now CMV IgM+. This is probably primary CMV infection with tissue invasive disease
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For a patient in whom there is a high pre-test probability for Clostridium difficile infection: a positive C difficile PCR with a negative EIA for toxin, does not rule out C difficile. False negative tests for the EIA toxin do occur.
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ID quiz: pt with neutropenia and blood culture with Rhodotorula. What is your fist line antifungal therapy
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more about this organism and the skin Seroy J, Antiporta P, Grim SA, Proia LA, Singh K, Clark NM. Aspergillus calidoustus case series and review of the literature. Transpl Infect Dis. 2017 Oct;19(5). doi: 10.1111/tid.12755. Epub 2017 Sep 19. PMID: 28741738.
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Aspergillus calidoustus. I have seen it have a tendency for cutaneous involvement. Tends to be resistant to azoles. Here is another one from the literature. https://t.co/CFaGe9mrQY.
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Thank you to today’s panel of MMI Thursday Seminar presenters — David Sullivan, MD, & our guests from @HopkinsMedicine moderator Dan Hanley, MD, @ShohamTxID, Nicole McBee & Karen Lane! Great interactive discussion about their multi-center #COVID-19 clinical trial
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Estimates of actual and potential lives saved in the United States from the use of COVID-19 convalescent plasma | PNAS
pnas.org
In the Spring of 2020, the United States of America (USA) deployed COVID-19 convalescent plasma (CCP) to treat hospitalized patients. Over 500,000 ...
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many reasons why life expectancy in US is falling. I have to imagine the painfully system for getting medications covered by insurance companies is one of them. Without A LOT of work on the part of patients there are a million ways that things don't work out.
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https://t.co/zZSEfkZqCe via @IDSAInfo Changes are needed badly. Thank you IDSA for working on this
idsociety.org
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amongst the best of Israel right here in this video
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I will be in Baltimore MD starting tomorrow Monday Nov 6 until Wednesday Nov 8 speaking at @JohnsHopkins @HopkinsMedicine @JHUPress meeting with extraordinary friends and colleagues as well as the medical students and residents
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