ZhuLab_Shanghai
@ShanghaiZhulab
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Principle Investigator, Mass Spectrometry, Metabolomics
Shanghai, China
Joined December 2020
Happy to share the 3nd generation of MetDNA out in @NatureComms
nature.com
Nature Communications - Accurate metabolite annotation remains a major challenge in untargeted metabolomics. Here, the authors present MetDNA3, a framework that integrates knowledge and data-driven...
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What a wonderful journey! Happy to share our latest work out @NatureChemistry We develop a subcellular photocatalytic labelling strategy that enables organelle-selective lipid analysis by MS .
nature.com
Nature Chemistry - Subcellular lipid transport between organelles and turnover remain poorly explored due to the technical challenges associated with selective lipid labelling. Now a subcellular...
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Another work on in vivo stable-isotope tracing metabolomics. We revealed tissue-specific fatty acid biosynthesis and inter-tissue crosstalk in mice through mass spectrometry-resolved stable-isotope tracing metabolomics.
advanced.onlinelibrary.wiley.com
Biosynthesis rates of 13 FFAs are quantitatively calculated in 15 tissues from glucose and an analytical framework to quantitatively calculate inter-tissue communications of fatty acids between the...
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Happy to share our work IsoNet. Using mass spectrometry-resolved stable-isotope tracing metabolomics, we develop an isotopologue similarity networking strategy to effectively deduce previously unknown metabolic reactions.
nature.com
Nature Communications - IsoNet, an isotopologue similarity networking strategy based on mass spectrometry-resolved stable-isotope tracing metabolomics, enables ab initio elucidation of unknown...
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Finally out! Happy to share our work @ScienceAdvances . We elucidate that citrulline served as a potential inhibitor of mTOR activation in macrophage and regulated the mTOR–HIF 1α–glycolysis signaling pathway to counter inflammation and aging. https://t.co/4bD0vqpbxN
science.org
Citrulline acts as an endogenous metabolite antagonist to aging and inflammation by regulating mTOR-HIF1α-glycolysis pathway.
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Happy to share our collobrative work with Prof. Junying Yuan which identified that metabolite spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression
nature.com
Nature Cell Biology - Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated...
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Met4DX supports data processing of both 3-dimensional LC-MS data and 4-dimensional LC-IM-MS data. Welcome to use!
Met4DX: A Unified and Versatile Data Processing Tool for Multidimensional Untargeted Metabolomics Data #JASMS
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Application scenarios using MetDNA2
Hot off the press! Happy to share a co-first author study that reveals shared and distinct metabolic disturbances associated with cardiovascular events in coronary artery disease https://t.co/5YvRlVZ5mD
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Happy to share our work with Prof. Xu. We used sterolomics technology and identified cholesterol metabolites shapes immune landscape of colorectal cancer https://t.co/VyJu6jKgDi
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Happy to share our collobrative work which identified that lysophosphatidylcholine (LPC) binds α-synuclein and prevents its pathological aggregation https://t.co/kvTRXHKhDe
academic.oup.com
α-Synuclein (α-syn) was found to preferentially bind lysophospholipids (LPLs), particularly targeting lysophosphatidylcholine (LPC). LPC plays a critical r
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Looking forward to presenting at the 4th Nordic #Metabolomics Conference #NMetC2024
That will be a fun meeting! It gets even better! Mtg will be followed by BioCity symposium, with focus on #metabolism
https://t.co/B42lU258sb So, a great metabolic week in Turku coming up! #metabolomics #lipidomics
@jingyuan_fu @MaruMongeCIBION @ShanghaiZhulab @tomas_pluskal
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Excellent lineup of invited speakers at #NMetC2024
@tomas_pluskal
@MaruMongeCIBION
@ShanghaiZhulab
@jingyuan_fu
@OttarRolfss
@anarmateos
@MaariaKortesni1 Egon Willighagen Majority of talks selected from abstracts (WWW pages opening soon). Conf. dinner in Turku castle.
Save the date: 4th Nordic #Metabolomics Conference #NMetC2024 will be in Turku on August 26-28, 2024, with #earlycareer event on 25th. We will be online soon, with registration and abstract submission opening. @matejoresic @KatiHanhineva @AlexDickens13 @BioscienceTurku @UniTurku
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What a amazing work! Huge congratulations, Pieter!👏 @Pdorrestein1
I am so excited that @em_gentry1 (@gentrylab) paper on reverse metabolomics to discover molecules is published, a project started in 2018. She found many new lipids and bile acids in humans. https://t.co/OcSxgEIBPt (online https://t.co/OFNSviRq6i) What is reverse metabolomics?
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Delighted to share our great collaboration! Using MetDNA( https://t.co/AZTZH1SQnY), we found intestinal phenylethylamine promotes the susceptibility of female mice to multiple sclerosis and N2-acetyl-L-lysine inhibits neuroinflammation during the disease. https://t.co/DV7KvgHths
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Thank you so much, Prof. Oresic! It is our fortune to have the opportunity to invite you to deliver an excellent presentation here in China. Hope you had a great time with us🤗🤗
Had a great time at Chinese #metabolomics meeting. Nearly 1000 participants, great science, energy, food and company. Ph 2: invited speakers. Ph 3: with local org Shuhai Lin, Secr of Chinese MetSoc Prof Jiang Zhu and CMS Pres Prof Huiru Tang. Short visit, but next year longer.
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We are so exciting that Prof. Matej Oresic flies to China as our plenary speaker for the 3nd Annual Conference for the Chiniese Society of Metabomics! What a wonderful presentation on microbiome, bile acids, and exposome for up to 800 attendees👏👏👏 Thank you, Prof. Oresic!
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What a wonderful ZhuLab 10th Anniversary party!👏👏👍😀😊🤗🤗🤗 Thanks so much all former and current members. Looking forward to the next 10, 20... years🤗
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Hot off the press😀My group started constructing a database for CCS values of small molecular compounds in 2015. After eight years and three generations of development, the AllCCS database has become increasingly mature. We welcome everyone to use it. 🙌 https://t.co/8rSyaMe59L
pubs.acs.org
The development of ion mobility–mass spectrometry (IM–MS) has revolutionized the analysis of small molecules, such as metabolomics, lipidomics, and exposome studies. The curation of comprehensive...
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Happy to share our new work in which we developed MetImage to encode LC–MS-based untargeted metabolomics data into multi-channel digital images towards clinical diagnosis.
pubs.acs.org
Liquid chromatography–mass spectrometry (LC–MS)-based untargeted metabolomics provides comprehensive and quantitative profiling of metabolites in clinical investigations. The use of whole metabolome...
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Happy to share our new work. We develop a mass spectrum-oriented bottom-up assembly algorithm Met4DX for ion mobility-resolved metabolomics. Congrats the Team! https://t.co/0etekqdWIC
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