Selbach Lab
@SelbachLab
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Real flying ion Circus studying the proteome and its dynamics @BIMSB_MDC @MDC_Berlin
Berlin, Deutschland
Joined May 2017
MEK inhibition + growth factor → unexpected JNK activation.💥 Dual inhibition = significantly impaired tumor cell growth .🔬 SPIED-DIA = a powerful tool to dissect signaling & resistance. #phosphoproteomics #cancerresearch #SPIED_DIA #MEKinhibition #DIA #precisionmedicine.
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We present SPIED-DIA – a spike-in enhanced phosphoproteomics method combining DIA with targeted sensitivity to uncover synergistic signaling in colorectal cancer cells. 👉 [(.
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What happens to all those alternative transcripts?. 👉 Many are translated.👉 Proteolytic processing adds even more diversity. Integrated mRNA & protein isoform landscape now out on bioRxiv! . . #proteomics #transcriptomics #systemsbiology.
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Excited to share our new paper in MCP! 🎉 DIA with Spike-In SILAC (DIA-SiS) boosts proteome coverage and quantification. Check it out: #Proteomics #MassSpec #Research.
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Read our latest preprint on targeted phosphoproteomics: "Spike-in enhanced phosphoproteomics uncovers synergistic signaling responses to MEK inhibition in colon cancer cells.": #Phosphoproteomics #DIA #CancerResearch #Signaling #ColonCancer.
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Read the latest preprint on medRxiv: Cross-platform Clinical Proteomics using the Charite Open Standard for Plasma Proteomics (OSPP).
Want to do absolute quantitative plasma proteomics, with an internal standard that costs you less than 1€ per sample? Have a look at our OSPP
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Combining data independent acquisition with spike-in SILAC (DIA-SiS) improves proteome coverage and quantification. Read our new preprint on bioRxiv. #SILAC .#DIA.#Proteomics.
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Read our latest work on how phosphorylation in Intrinsically Disordered Regions (IDRs) affects protein-protein interactions in Nature Communications. @TRrustemi . #IDR.#phosphorylation.
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We would like to congratulate Fabian @CosciaLab for being awarded the European Research Council (ERC) Starting Grant 👏. #ERC .
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Our latest preprint investigates the pathogenic mutations of human phosphorylation sites that affect protein-protein interactions. Using peptide-based interaction proteomics, more insights regarding the transcription factor GATAD1 were unveiled. @TRrustemi
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We completed a 5x5 km team relay yesterday. Some of us already look forward to running again next year.
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Interested in joining our Proteome Dynamics lab in Berlin? We are offering a postdoc position:
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Looking for a method to identify drug targets? Our new paper on drug target identification by quantitative proteomics is now online:
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How can you predict kinase activity in phosphoproteomic data? This database allows you to do this, even for poorly annotated kinases. Read more in this new paper: .
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Given the energy required for protein synthesis, degrading proteins seems to be wasteful. Read about the physiological functions of protein degradation in this new review:
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