Sebastian Maerkl
@SebastianMaerkl
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Prof at @EPFL @Maerkllab. Into tech, bio, inventing, problem solving.
Lausanne/Basel Switzerland
Joined February 2013
Laura and Jiami's paper is out now on BioRxiv! Nice collaboration with the Reddy lab at ETHZ: "High-throughput cell-free profiling of SARS-CoV-2 RBD variants enables rapid and quantitative in vitro affinity landscape mapping." https://t.co/s5HE3XOYGV
biorxiv.org
SARS-CoV-2 variants continue to threaten public health, necessitating the study of cumulative and epistatic effects of receptor-binding domain (RBD) mutations on antibody evasion. We present a...
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De novo design of phosphorylation-induced protein switches for synthetic signaling in cells 1. Researchers have developed a method to design synthetic proteins that can switch states in response to phosphorylation, mimicking natural cellular signaling mechanisms. This
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Pao-Wan, Saeed and Matthis' paper is out now on BioRxiv: "A T7 RNAP regulatory toolbox for cell-free network engineering and biosensing applications" https://t.co/f7MCiZM6o9
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Pao-Wan's review on cell-free regulatory components is out now! Regulatory Components for Bacterial Cell-Free Systems Engineering | ACS Synthetic Biology
pubs.acs.org
Cell-free systems are advancing synthetic biology through fast prototyping and modularity. Complex regulatory networks can now be implemented in cell-free systems enabling various applications, such...
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Laura (@SuNMIL_EPFL) and Laura's paper on running the PURE system for weeks using a simple mesoscale dialysis system is now on bioRxiv!! "Long-term protein synthesis with PURE in a mesoscale dialysis system"
biorxiv.org
Cell-free systems are powerful tools in synthetic biology with versatile and wide-ranging applications. However, a significant bottleneck for these systems, particularly the PURE cell-free system, is...
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The Maerkl Lab is hiring one or two graduate students to work in the area of cell-free synthetic biology, specifically synthetic cell engineering! Deadline for our EDBB doctoral program is Nov 1st ... See below for more information: https://t.co/tWNJBzbzNJ
eth-gethired.ch
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Ragu's paper is now officially out in ACS SynBio: Towards Self-regeneration: Exploring the Limits of Protein Synthesis in the Protein Synthesis Using Recombinant Elements (PURE) Cell-free Transcription–Translation System | ACS Synthetic Biology
pubs.acs.org
Self-regeneration is a key function of living systems that needs to be recapitulated in vitro to create a living synthetic cell. A major limiting factor for protein self-regeneration in the PURE...
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Laura's paper from the Stellacci lab (@frstella) is out now: Nature-Inspired Recycling of a Protein Mixture into a Green Fluorescent Protein-based hydrogel - now published in RSC Sustainability https://t.co/oLMxdY5tlE
pubs.rsc.org
Protein-based materials are biocompatible and have a variety of remarkable properties; consequently, they are finding more and more applications. Nature recycles proteins in multiple ways, ranging...
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Amogh's comprehensive review of microfluidic approaches and applications in cell-free synthetic biology is out now! #microfluidics #cellfreesynbio #synbio #syntheticbiology
https://t.co/QQ3EMNJc6e
frontiersin.org
Cell-free synthetic biology has gained increasing popularity owing to its ability to elucidate biological functions in isolation from intricate cellular envi...
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Ragu's paper describing a minimal PURE system is now on BioRxiv!! Towards self-regeneration: exploring the limits of protein synthesis in the PURE cell-free transcription -translation system https://t.co/YmD94aodRw
biorxiv.org
Self-regeneration is a key function of living systems that needs to be recapitulated in vitro to create a living synthetic cell. A major limiting factor for protein self-regeneration in the PURE...
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Self-assembled cell-scale containers made from DNA origami membranes
biorxiv.org
DNA origami provides a methodology for the sequence-programmable generation of precisely defined molecular nanostructures with sizes of order 100 nm. A new frontier for the field is the generation of...
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Congratulations to our post-doc Fanjun who was just awarded a SNF Spark grant! Spark grants fund "rapid testing or development of novel and unconventional scientific approaches, methods, theories, standards and ideas", which is right up our alley! https://t.co/nvOtr7oWxA
snf.ch
Rapid funding of unconventional ideas
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Laura and Paula's paper is out now! "C2CAplus: A One-Pot Isothermal Circle-to-Circle DNA Amplification System" https://t.co/DYeSta2RxW
pubs.acs.org
Rolling circle amplification (RCA) is a widely used DNA amplification method that uses circular template DNA as input and produces multimeric, linear single- or double-stranded DNA. Circle-to-circle...
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I wrote a short discussion "On biochemical constructors and synthetic cells", which was just published. Check it out: https://t.co/4JLnp8AufP
royalsocietypublishing.org
Is it possible to build life? More specifically, is it possible to create a living synthetic cell from inanimate building blocks? This question precipitated into one of the most significant grand...
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C2CAplus: a one-pot isothermal circle-to-circle DNA amplification system. Laura and Paula's work on developing an improved phi29 based DNA amplification system is out now on BioRxiv!
biorxiv.org
Rolling circle amplification (RCA) is a widely used DNA amplification method that uses circular template DNA as input and produces multimeric, linear single or double stranded DNA. Circle-to-circle...
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"A field-capable rapid plant DNA extraction protocol using microneedle patches for botanical surveying and monitoring" We published our first article with the master and bachelor student MAKE project Genorobotics! Congrats everybody who contributed! https://t.co/8VjgXEpckZ
bsapubs.onlinelibrary.wiley.com
Premise A novel protocol for rapid plant DNA extraction using microneedles is proposed, which supports botanic surveys, taxonomy, and systematics. This protocol can be conducted in the field with...
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"Imagine the kind of technological progress humanity could make if we could start designing novel proteins for personalised medicines, industrial applications like new enzymes, or better, more sustainable materials." https://t.co/Wef9Yd4zeq
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We are so happy to see our proof of concept work on protein recycling was listed as one of the most downloaded articles 🥳 @frstella @WileyGlobal @SebastianMaerkl Congratulations to all authors🤩 In case you might have missed it or want to revisit it: https://t.co/y3FL61kaea
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Die Extraktion von #Pflanzen-#DNA ist meist mühsam und zeitraubend. Ziemlich schnell und einfach geht es im @MaerklLab am @EPFL – und zwar mit nadelÂbewehrten Plastikstreifen … — Andrea Pitzschke stellt Tricks und Technik vor: https://t.co/eb1apgAAkz
#dnaextraction #labtool
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Here is a first! A manuscript from a student run project (bachelor and master). A field-capable rapid plant DNA extraction protocol using microneedle patches for botanical survey and monitoring https://t.co/yrmPQL3zAx
biorxiv.org
Premise A novel protocol for rapid plant DNA extractions using microneedles is proposed, which supports botanic surveys, taxonomy and systematics. This protocol can be conducted in the field with...
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