Sardiello Lab
@SardielloLab
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Washington University in St. Louis. Main topics: lysosomal and mitochondrial biogenesis, neurodegenerative diseases, TFEB.
St. Louis, MO
Joined February 2017
Very proud to share our latest publication on the discovery of #KCTD7 function and #calpain regulation by atypical ubiquitination. Massive kudos to superb lead author @JaiSharma__ whose visionary ideas and tireless efforts were crucial to make it happen! https://t.co/mwxQqtdDUA
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Great work from the @HastingsLab!
Therapeutic efficacy of antisense oligonucleotides in mouse models of CLN3 Batten disease | Nature Medicine
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Amazing work from the @ZhandongLiu lab! Coexpression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disorders https://t.co/wHV7VjCVy9
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The Sardiello lab has just moved to Washington University in St. Louis. Contact us if interested to join as a post-doc, computer scientist, or lab manager/technician.
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Solving the CNL6 mystery in Batten disease:
bcm.edu
Batten disease is a family of 13 rare, genetically distinct conditions. Collectively, they are the most prevalent cause of neurodegenerative disease in...
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Congratulations @lakshyabajaj5 @SardielloLab et al for solving the #CLN6 puzzle in #BattenDisease! @jclinicalinvest @bcmhouston @TCHResearchNews
Super stoked to finally see my graduate school paper out today in @jclinicalinvest. We show that a CLN6-CLN8 complex (that we refer to as EGRESS: ER-to-Golgi relaying of enzymes of the lysosomal system), recruits lysosomal enzymes at the ER to promote their Golgi transfer.
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Super stoked to finally see my graduate school paper out today in @jclinicalinvest. We show that a CLN6-CLN8 complex (that we refer to as EGRESS: ER-to-Golgi relaying of enzymes of the lysosomal system), recruits lysosomal enzymes at the ER to promote their Golgi transfer.
Dr. M Sardiello @SardielloLab, Dr. L. Bajaj et al reveal in @jclinicalinvest how #CLN6 can cause #BattenDisease @bcmhouston @TCHResearchNews
https://t.co/RuyMkwCR3O
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Our new article showing that CLN6 and CLN8 are obligate partners in the recruitment of lysosomal enzymes in the endoplasmic reticulum for Golgi transfer
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Very proud and grateful for this award. A big thank you to all past and current lab members and our many collaborators!
Five researchers received the 2019 Michael E. #DeBakey M.D. #Award for Excellence in #Research @amilosav @SardielloLab @BrittonTML @BCMCancerCenter @TCHResearchNews
https://t.co/lf0ksLUfgJ via @bcmhouston
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Check out our new PNAS paper showing mTORC1-independent lysosomal depletion and abnormal glycogen storage in tuberous sclerosis https://t.co/36ywAamlOA
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How can #mutations in a #protein that is not in the #lysosome result in a #lysosomalstoragedisorder? #CLN8 @SardielloLab @NatureCellBio @bcmhouston @TCHResearchNews
https://t.co/SMot6kmNL6
#Batten
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Dr. Paul Luzio's commentary on our article "CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis" https://t.co/iE2f3aG2I2
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Our new article showing that ER-to-Golgi transport of lysosomal enzymes requires CLN8, a Batten disease protein. #lysosome #NatureCellBio
https://t.co/ceQWFoI1sb
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Our new article showing that Src controls mTORC1 activity https://t.co/g0NCPpfwFn
nature.com
Nature Communications - The growth-promoting activity of mTORC1 is regulated by amino acid availability via the Rag GTPases. Here, the authors demonstrate Src-dependent control of cell size and...
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Our #Autophagy paper is finally out! Congrats Parisa and a big thank you to all our collaborators. https://t.co/ILd9iHIdVn
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Our review on the autophagy-lysosomal pathway in LSDs and late-onset neurodegenerative diseases is out! https://t.co/kCO3aO9B1F
annualreviews.org
One of the fundamental properties of the cell is the capability to digest and remodel its own components according to metabolic and developmental needs. This is accomplished via the autophagy-lysos...
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Gene playing major role in neurological condition found | Baylor College of Medicine | Houston, Texas https://t.co/fn5CRXZRgG via @bcmhouston
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