Safavi Lab
@SafaviLab
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Exploring and developing applications of biomedical peptides from marine venoms | Tweets by lab members. #conesnails #venom π©πͺπ΅ππ©π°ππ°πΊπΈπ«π·π¦πΊ
Salt Lake City, Utah, USA
Joined January 2021
Another news piece on why cone snail venom is an untapped source of drug discovery. Thanks for covering our studies!.
A deadly sea snail has evolved a unique method of hunting that uses insulin-like compounds as a biological weapon. Research reveals that the geography cone snail releases a mix of mimic molecules into the water, altering its preyβs #metabolism and inducing a state of stupor. This
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A very nice piece covering our story on the unusual glucose-lowering hunting strategy used cunningly by the fish-hunting cone snail, Conus geographus. Check it out!.
Cone snails in the tropical waters of Palau have a secret weapon. Researchers (@UUtah) found that one cone snail deploys insulin- and somatostatin-mimicking toxins that crash fish blood glucose levels.
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A great cover story in @nytimes magazine showcasing how venomous animals provide ingenious solutions to solve some of the long-standing problems in drug development. It was great showing Kim our cone snail aquarium, and our exciting research.
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Another example of why cone snails are rich drug source! Another great collaboration with the Toto Olivera lab at @UUtah.
Cone snails produce Ο-conotoxin to hunt other snails. These toxins are potential anti-pain drugs. Funtastic work from Sam Espino and collaborators of the Olivera Lab! #ConeSnails #conotoxin #venom.
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RT @JulieCKiefer: "What do online grocery shopping, venomous snails, and foot biomechanics have in common?" . Find out! . Largest-Ever @β¦.
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Donβt miss out on this seminar featuring our very own Dr Thomas Koch!.
Join us on 9 October at 5pm CET for a new EUVEN seminar featuring Thomas Koch discussing cone snail venom evolution, and Schyler Ellsworh discussing mechanisms of venom resistance in flies. Register at @Schy_Ellsworth @LundKoch
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Great opportunity to work in a great lab with a great mentor!.
Interested in #pain #pharmacology and structural biology and looking for a master's thesis project in Copenhagen?. Read here to see more and apply for an intriguing project:.
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Helena gave a stellar tenure talk today, drawing different examples of prey-hormone mimicking, doppelgΓ€nger toxins found in cone snail venoms!
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RT @UofUBiochem: On Thurs Sept 12, Helena Safavi @SafaviLab will give her tenure talk entitled "Insights from the Biology, Behavior, and Evβ¦.
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Proud to present our newly minted Dr Sophie PhD of the Safavi lab! πππππ very well deserved for all her hard work! Also nice to see past members of the Safavi lab in Copenhagen!
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What a great time at Yellowstone πwith @StingScience, @waldensciencing, @LundKoch, @yeung_hyw, @irisbeara and other amazing people (Lars, Celeste, Vanessa) from π©π°π¦πΊwho are not on the X universe. Looking forward to your next visit in Salt Lake City!
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RT @MolBioEvol: Be sure to check out the full article by @SafaviLab @LundKoch @UofUBiochem: Prey Shifts Drive Venom Evolution in Cone Snailβ¦.
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π§΅4/5 This work is led by @yeung_hyw, @irisbeara, @LundKoch and @waldensciencing from our lab. Also amazing collaborations from groups at UCPH @UCPH_health π©π°@Alphacell_metab, @H_Brauner, @kattesch, Jens Juul Holst and Toto Olivera's lab at the U of Utah πΊπΈ @UUtah @UofUBiochem!.
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π§΅3/5 We are currently looking into the medical applications of the insulin and somatostatin-like toxins for the treatment of diabetes and hormone disorders. By taking inspiration from cone snails and other venomous animals, we can discover many more novel drug leads.π.
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π§΅2/5 This study is an extraordinary example of the uses of highly target-specific and stable toxins that have been evolutionarily optimized to the advantages of the cunning cone snails.π―.
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Excited to share our latest story on how fish-hunting cone snail uses a combination of weaponized insulin and somatostatin-like toxins to disrupt glucose level in its fish prey πβ‘οΈπ π¬.Check out our paper and animation to learn more:.@NatureComms π§΅1/5
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Done with the group meeting. On our way to get lunch, good beer and milk tea :D #CaloriesDontCountOnThursdays
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