Full article in Radiology: https://t.co/BnidPS4OBe #Radiology #MASLD #MRI #T2DM @RITEditor @Radiology_Editor @ProfVickyGoh @chemshift1 @VChernyakMD

Take-home: - MRI-derived PDFF predicts prediabetes & diabetes risk in obesity. - Shows a robust, dose–response relationship, validated in an independent cohort. - Radiologists can report PDFF values as clinically actionable information. A step toward precision metabolic imaging.

Clinical relevance: - Liver PDFF is more than just a steatosis marker. - It can serve as a quantitative metabolic biomarker, aiding risk stratification in obesity. - Even mild elevations may carry important risk implications.

Mechanistic insight: The PDFF–dysglycemia link was partially mediated by: - ALT (38.8%) - AST (27.3%) Suggests hepatocyte injury is a key pathway connecting steatosis with glucose dysregulation.

Key results: - Each 1% increase in PDFF → OR 1.04 for prediabetes/T2DM (P<.001). - Severe steatosis (PDFF≥25%): OR ~3.5 for both prediabetes & #diabetes. - Independent cohort confirmed higher PDFF in dysglycemia (19.7% vs 12.9%).

Study design: - Retrospective cohort of 683 obese adults (BMI ≥28). - MRI-PDFF measured liver fat across all 8 Couinaud segments. - 75g OGTT classified glycemic status (normal, prediabetes, T2DM). - Independent validation cohort (n=100).

Background: #MASLD (metabolic dysfunction–associated steatotic liver disease) is tightly linked with #T2DM. But how exactly does liver fat, quantified noninvasively, translate into prediabetes/T2DM risk in obesity? MRI-PDFF offers a precise, quantitative answer.

📢 New in @Radiology_RSNA: Liver MRI–derived proton density fat fraction (PDFF) predicts #diabetes risk in pts with obesity, with a clear dose–response relationship. Deng et al. https://t.co/BnidPS4OBe @RITEditor @Radiology_Editor @ProfVickyGoh @chemshift1

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Proud to be learning from the BEST! #SABI2025 @YaleRadiology @SABImaging

Proud of our very own @YaleRadiology resident, Dennise Caruana, for an awesome presentation today! #SABI2025 #radres

As the #Match2026 season picks up, we’re excited to share our recent publication: Applying for an American Radiology Residency As an International Medical Graduate: The NRMP Match. We hope this guide supports your journey, and we wish all IMGs the very best in the months ahead!

Hello #MedTwitter! I’m Mahnaz Hosseinibensenjan, MD-MPH, and a research scholar @UCSD_Liver Imaging Group Excited to apply for Diagnostic Radiology in #Match2026 (AAMC: 16752344) Looking forward to connecting with peers and programs! #RadTwitter #FutureRadRes @Inside_TheMatch

Hello #MedTwitter! I’m Niloufar, an IMG grad & a postdoctoral researcher now @uciradiology, thrilled to begin my #Match2026 journey (AAMC: 16260471) after years of passion for #DiagnosticRadiology 🩻 Outside the hospital, I find inspiration and refuel with painting🎨 & exploring

Hello #MedTwitter! I’m Negar (Nela), a US-IMG grad of @TehUofMed and current research fellow at @UWRadiology applying for Diagnostic Radiology for #Match2026. In my free time, I love cuddling with my cats or hiking in the beautiful scenery of Seattle🌲 Looking forward to

9/ Read more in Radiology: Wooldrik SM, van de Voort EMF, Struik GM, et al. “Percutaneous thermal ablation for early-stage breast cancer” @VChernyakMD @RITEditor @RadiologyEditor 🔗

8/ Conclusion Cryoablation emerges as the preferred technique for future trials evaluating percutaneous thermal ablation as an alternative to surgery in early-stage breast cancer.

7/ Why it matters Breast-conserving surgery is standard for early-stage breast cancer. But a safe, effective, minimally invasive alternative could: - Reduce morbidity - Improve cosmetic outcomes - Expand patient options

6/ Take-home message: Cryoablation achieved the best balance: ✅Highest pCR (94%) ✅No complications ✅Well tolerated, outpatient feasible 👉Selected for phase III trial as potential surgical alternative

5/ Procedural details: - All under local anesthesia, outpatient setting - MRI pre- and post-ablation confirmed treatment effect - Pain scores low, usability scores high - Adverse events (skin burns, need for oncoplastic surgery) occurred only in RFA/MWA arms