Ryan Cook
@RyanCookAMR
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Viral ecologist with @EvelienAdri at @TheQuadram | All things phage (but mostly viromes) | Formerly at @UniofNottingham with @milja001 | All opinions my own.
Norwich, England
Joined May 2019
New pre-print alert! 🚨🫁. COPD affects millions worldwide. While we know bacterial dysbiosis drives disease, the role of bacteriophages remains unexplored. We re-analysed 135 COPD metagenomes to characterise the lung virome for the first time 🫁 1/9.
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RT @GB13Faithless: Stoked to finally have a preprint out for Phold, our tool that uses protein structural information to enhance phage geno….
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RT @milja001: After hiatus, as @RyanCookAMR were a bit busy . we have updated links to latest INPHARED dataset. With 37.5K genomes now….
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RT @NobregaFL: Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication an….
cell.com
Zhang, Todeschini, and Wu et al. show that the bacterial defense system Kiwa senses phage attachment at the membrane and assembles a transmembrane complex that halts infection by blocking phage DNA...
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RT @RyanCookAMR: This is probably my last piece of work from my.@MedResFdn funded PhD at @UniofNottingham (thanks for all the support over….
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RT @RyanCookAMR: The dairy cow gut virome is a dynamic ecosystem that could be an under-studied player in sustainable agriculture 🔑. Prepri….
biorxiv.org
Ruminant gut microbial communities profoundly influence host health and environmental impacts, yet their viral components remain poorly characterised across developmental transitions. Here, we...
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RT @RyanCookAMR: From a practical standpoint: The viral community shake-ups during weaning and drying-off suggest these could be critical w….
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RT @RyanCookAMR: The transition from "human-like" calf viromes to specialised ruminant adult viromes mirrors what we see in human infant de….
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RT @RyanCookAMR: Mapping to public databases corroborated the patterns described above:. 🐄 Calves: more simple communities, similar to huma….
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RT @RyanCookAMR: Not only phages though, we found 26 viruses that predicted to target methanogenic archaea 🌎 . Absent in calves, but presen….
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RT @RyanCookAMR: Drying-off period emerged as a viral hotspot 🔥 .-Highest viral diversity.-Lowest bacterial diversity.-High virus-to-host r….
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RT @RyanCookAMR: Bacterial and viral communities were strongly associated across all groups but in adults, viral and bacterial diversity we….
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RT @RyanCookAMR: We observed ecological shifts across life stages:. 🐄 Calves: Low diversity, dominated by temperate phages, similar to huma….
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RT @RyanCookAMR: 1,338 vOTUs predicted complete. @milja001 and I agreed to manually inspect annotations of every single one. I started at t….
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RT @RyanCookAMR: We profiled the faecal virome of dairy cows across key life stages with ultra-deep ONT and Illumina sequencing 🐮. We recov….
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RT @RyanCookAMR: Why does this matter? Dairy cows = 265 million worldwide, huge importance in food production and greenhouse gas emissions.….
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RT @RyanCookAMR: 🧬🐄 NEW PREPRINT: Really happy to finally share the last big piece of work from my PhD! . Spoiler: Cows are great and so ar….
biorxiv.org
Ruminant gut microbial communities profoundly influence host health and environmental impacts, yet their viral components remain poorly characterised across developmental transitions. Here, we...
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RT @RyanCookAMR: This was a fun collaboration with scientists/clinicians from University of Leicester and Guangzhou, China. With contributi….
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RT @RyanCookAMR: These findings establish altered bacteriophage ecology as an unrecognised feature of COPD pathobiology, with differential….
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RT @RyanCookAMR: Found (pro)phages carrying virulence genes. Patients with neuA-encoding Haemophilus phages had 82-fold higher bacterial lo….
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RT @RyanCookAMR: Four patients had extreme viral loads (>10% metagenomic reads). Two had eukaryotic viruses, two had bacteriophage "blooms"….
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