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Ryan Cook Profile
Ryan Cook

@RyanCookAMR

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Viral ecologist with @EvelienAdri at @TheQuadram | All things phage (but mostly viromes) | Formerly at @UniofNottingham with @milja001 | All opinions my own.

Norwich, England
Joined May 2019
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@RyanCookAMR
Ryan Cook
1 month
New pre-print alert! 🚨🫁. COPD affects millions worldwide. While we know bacterial dysbiosis drives disease, the role of bacteriophages remains unexplored. We re-analysed 135 COPD metagenomes to characterise the lung virome for the first time 🫁 1/9.
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: This is probably my last piece of work from my.@MedResFdn funded PhD at @UniofNottingham (thanks for all the support over….
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: The dairy cow gut virome is a dynamic ecosystem that could be an under-studied player in sustainable agriculture 🔑. Prepri….
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biorxiv.org
Ruminant gut microbial communities profoundly influence host health and environmental impacts, yet their viral components remain poorly characterised across developmental transitions. Here, we...
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: From a practical standpoint: The viral community shake-ups during weaning and drying-off suggest these could be critical w….
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: The transition from "human-like" calf viromes to specialised ruminant adult viromes mirrors what we see in human infant de….
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: Mapping to public databases corroborated the patterns described above:. 🐄 Calves: more simple communities, similar to huma….
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: Not only phages though, we found 26 viruses that predicted to target methanogenic archaea 🌎 . Absent in calves, but presen….
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: Drying-off period emerged as a viral hotspot 🔥 .-Highest viral diversity.-Lowest bacterial diversity.-High virus-to-host r….
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: Bacterial and viral communities were strongly associated across all groups but in adults, viral and bacterial diversity we….
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: We observed ecological shifts across life stages:. 🐄 Calves: Low diversity, dominated by temperate phages, similar to huma….
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: 1,338 vOTUs predicted complete. @milja001 and I agreed to manually inspect annotations of every single one. I started at t….
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: We profiled the faecal virome of dairy cows across key life stages with ultra-deep ONT and Illumina sequencing 🐮. We recov….
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: Why does this matter? Dairy cows = 265 million worldwide, huge importance in food production and greenhouse gas emissions.….
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: 🧬🐄 NEW PREPRINT: Really happy to finally share the last big piece of work from my PhD! . Spoiler: Cows are great and so ar….
Tweet card summary image
biorxiv.org
Ruminant gut microbial communities profoundly influence host health and environmental impacts, yet their viral components remain poorly characterised across developmental transitions. Here, we...
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: This was a fun collaboration with scientists/clinicians from University of Leicester and Guangzhou, China. With contributi….
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: These findings establish altered bacteriophage ecology as an unrecognised feature of COPD pathobiology, with differential….
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: Found (pro)phages carrying virulence genes. Patients with neuA-encoding Haemophilus phages had 82-fold higher bacterial lo….
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: Four patients had extreme viral loads (>10% metagenomic reads). Two had eukaryotic viruses, two had bacteriophage "blooms"….
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: Phages infecting oral anaerobes were disproportionately lower. Porphyromonas phages: 40-fold lower despite only 4-fold bac….
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: Despite diversity loss, viral communities showed minimal structuring by clinical phenotype. Only 4.5% variance explained b….
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@RyanCookAMR
Ryan Cook
1 month
RT @RyanCookAMR: Viral diversity progressively declined with COPD severity. Most striking: frequent exacerbators (Group E) showed complete….
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