Ryan Cook
@RyanCookAMR
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Viral ecologist with @EvelienAdri at @TheQuadram | All things phage (but mostly viromes) | Formerly at @UniofNottingham with @milja001 | All opinions my own.
Norwich, England
Joined May 2019
New pre-print alert! 🚨🫁. COPD affects millions worldwide. While we know bacterial dysbiosis drives disease, the role of bacteriophages remains unexplored. We re-analysed 135 COPD metagenomes to characterise the lung virome for the first time 🫁 1/9.
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RT @RyanCookAMR: This is probably my last piece of work from my.@MedResFdn funded PhD at @UniofNottingham (thanks for all the support over….
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RT @RyanCookAMR: The dairy cow gut virome is a dynamic ecosystem that could be an under-studied player in sustainable agriculture 🔑. Prepri….
biorxiv.org
Ruminant gut microbial communities profoundly influence host health and environmental impacts, yet their viral components remain poorly characterised across developmental transitions. Here, we...
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RT @RyanCookAMR: From a practical standpoint: The viral community shake-ups during weaning and drying-off suggest these could be critical w….
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RT @RyanCookAMR: The transition from "human-like" calf viromes to specialised ruminant adult viromes mirrors what we see in human infant de….
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RT @RyanCookAMR: Mapping to public databases corroborated the patterns described above:. 🐄 Calves: more simple communities, similar to huma….
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RT @RyanCookAMR: Not only phages though, we found 26 viruses that predicted to target methanogenic archaea 🌎 . Absent in calves, but presen….
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RT @RyanCookAMR: Drying-off period emerged as a viral hotspot 🔥 .-Highest viral diversity.-Lowest bacterial diversity.-High virus-to-host r….
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RT @RyanCookAMR: Bacterial and viral communities were strongly associated across all groups but in adults, viral and bacterial diversity we….
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RT @RyanCookAMR: We observed ecological shifts across life stages:. 🐄 Calves: Low diversity, dominated by temperate phages, similar to huma….
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RT @RyanCookAMR: 1,338 vOTUs predicted complete. @milja001 and I agreed to manually inspect annotations of every single one. I started at t….
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RT @RyanCookAMR: We profiled the faecal virome of dairy cows across key life stages with ultra-deep ONT and Illumina sequencing 🐮. We recov….
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RT @RyanCookAMR: Why does this matter? Dairy cows = 265 million worldwide, huge importance in food production and greenhouse gas emissions.….
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RT @RyanCookAMR: 🧬🐄 NEW PREPRINT: Really happy to finally share the last big piece of work from my PhD! . Spoiler: Cows are great and so ar….
biorxiv.org
Ruminant gut microbial communities profoundly influence host health and environmental impacts, yet their viral components remain poorly characterised across developmental transitions. Here, we...
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RT @RyanCookAMR: This was a fun collaboration with scientists/clinicians from University of Leicester and Guangzhou, China. With contributi….
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RT @RyanCookAMR: These findings establish altered bacteriophage ecology as an unrecognised feature of COPD pathobiology, with differential….
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RT @RyanCookAMR: Found (pro)phages carrying virulence genes. Patients with neuA-encoding Haemophilus phages had 82-fold higher bacterial lo….
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RT @RyanCookAMR: Four patients had extreme viral loads (>10% metagenomic reads). Two had eukaryotic viruses, two had bacteriophage "blooms"….
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RT @RyanCookAMR: Phages infecting oral anaerobes were disproportionately lower. Porphyromonas phages: 40-fold lower despite only 4-fold bac….
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RT @RyanCookAMR: Despite diversity loss, viral communities showed minimal structuring by clinical phenotype. Only 4.5% variance explained b….
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RT @RyanCookAMR: Viral diversity progressively declined with COPD severity. Most striking: frequent exacerbators (Group E) showed complete….
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