Father, Scientist, Co-Founder & CEO of $RXRX, ‘the OG of TechBio’ & 0x Forbes 30 under 30 winner - Tweeting TechBio, cars & musings… Typos & opinions my own.
1/
@Delta
I am a big fan and fly you religiously, but something unfortunate happened today, and your 'contact us' page says to tweet you. So here goes. Before boarding my delayed flight to SF, I witnessed a women who didn't speak English confronted aggressively by the gate agent.
I’m excited about the next stage of growth for
@RecursionPharma
as we become a public company - $RXRX! Our team has worked tirelessly to achieve this milestone and now it is time to put our heads down and get back to work on our mission! Thanks to all who have supported us!
In a Large Language Model like
@OpenAI
's ChatGPT , a model has been trained to predict the best next token (e.g., word) to add iteratively in a written response. As these models get trained across more and more data, they start to learn foundational elements of text which, when
@bradloncar
Totally agree
@bradloncar
. Here are a few tips for those looking to partner with various TechBio companies who themselves don't have deep AI expertise to apply to diligence.
1) Look for groups who have significant representation from both bio/chem on their teams as well as
When I finished my PhD and took a leave of absence from med school to start Recursion, I told my wife I thought the chances we would ‘make it’ were ~1%, but the impact would be so huge for patients if it worked that I had to try.
Surreal to think back to day one now 3651 days
Yesterday marked 10 years since our founding.
We've come so far in our mission to decode biology, but we're just getting started.🚀
#drugdiscovery
#techbio
Announcing a $121M
@RecursionPharma
Series C to fund our mission to decode biology to radically improve lives. With pgms in clinic, discoveries in new areas (IO, Inflammation, etc), an amazing team, and a resupply complete, it's head-down execute time!
H100s are in the
@RecursionPharma
house (undisclosed location) with our CTO
@bmabey
and team!
This is what one of the world’s fastest supercomputers looks like when it comes off the truck. Kudos to our team and our partners at
@nvidia
for the fast work and great collaboration!
As I boarded, I was given a receipt by another agent saying miles had been deposited in my medallion account as a thank you for helping out. I'd like those miles removed.
You have to have skin in the game!
Reflecting back on
#JPM2024
last week and this shot has to be a personal highlight. I was comparing company tattoos with NVIDIA founder & CEO Jensen Huang when
@RecursionPharma
Board Chair
@RMartinChavez
dropped his full sleeve Turing machine!
Getting pinged a lot on X about insider selling at
@RecursionPharma
. In general the volume of shares sold is low and the vast majority of Form 4s are via preplanned 10b5-1s.
But let me address my own buying and selling clearly, as many consider the CEO to be the most important
I am so excited to partner with the team
@nvidia
to further accelerate our pioneering work in AI leveraging their DGX Platform for drug discovery. This partnership, alongside our other partnerships with
@Roche
/
@genentech
and
@Bayer
makes it clear that the transition from
Today we announced a collaboration and $50 million investment from
@nvidia
to accelerate our groundbreaking foundation models in AI-enabled drug discovery.
Read the press release:
Read the blog from our CTO
@bmabey
:
Excited to share an exciting preprint out from
@RecursionPharma
where we demonstrate the power of phenomics at genome-scale to show that CRISPR-Cas9 induces chromosome arm-scale truncations that we call “Proximity Bias” across the genome. Pre-Print:
Not going to lie - I’m pretty excited about this one folks -
@recursion
is coming to LONDON and we are welcoming
@mmbronstein
as an advisor!
London is 🔥 when it comes to Tech X Bio talent, which is why we are making it our formal footprint in Europe. It also happens to be one
Next stop: LONDON! 🇬🇧
We’re expanding our operations to Europe, at the epicenter of the rapidly growing
#TechBio
sector in
#London
.
Learn more at and check out our new open positions at $RXRX
#biotech
#ai
#ml
Biology transitioned from Art —> Science in the last century.
In this century (and really the next decade) it will transition again from Science —> Engineering.
As
@nvidia
’s Jensen Huang shares, this shift will underlie extraordinary opportunity.
I am excited to be working at
3 months ago, I broke my back in a sports accident. Today I'm medically cleared and 'back in the saddle,' literally, on my
@onepeloton
for the first time. Amazing how much I've missed these sessions.
7 yrs ago today, pitching "4th dimension therapeutics" at the end of Stanford IGNITE. All the VCs fell asleep... but those ideas percolated into
@RecursionPharma
, more than 4 clinical programs, 25 discovery programs, 170+ amazing team members... and some BIG stuff to drop soon 😉
I finally paid the fee myself to make it really clear to the agent how off-base I thought she was being to the women. Hopefully the women can continue on with her travels absent what felt very much like harrassment to me.
Behind that mask my wife smiles a smile I know well - it's the same one she gives me and our boys each night when she gets home. But behind it I see deep pain and fear - not unlike the smile on days when she diagnosed a young person with ALS or lost a beloved patient.
To build broad foundational models in biology, you are going to need a lot of high quality data. Aside from a few problems (e.g. protein folding), that data doesn't currently exist in the public domain. The winners of TechBio will have access to high quality talent, deep compute
Get an early look at the power of our groundbreaking
#phenomics
foundation model! With results up to 28% better than prior models, our work demonstrates scaling properties apply in biology: larger models & more training data = superior performance.
Stay tuned for future papers
Was such a pleasure to do a LIVE DEMO of LOWE at the JP Morgan Healthcare conference. As far as I am aware, this was the first time that anyone has done a live software demo in the conference's 42 years.
We had the chance to present just a couple of hours before our colleagues
The future of drug discovery is here.
LOWE (LLM-Orchestration Workflow Engine) is a cutting-edge software designed to perform complex
#drugdiscovery
tasks using a natural language interface.
🎥 Discover what LOWE can do ⬇️
Learn more:
#JPM24
#TechBio
Taking another big step forward today
@RecursionPharma
as we lead TechBio with the appointment of Najat Khan, PhD to our Board of Directors and as Chief R&D Officer and Chief Commercial Officer. Najat is one of the most progressive and pragmatic thinkers in the TechBio space, and
Such a delight to host the incredible
@jpmorgan
Chairman and CEO Jamie Dimon onsite at
@RecursionPharma
HQ yesterday in Salt Lake City where we talked about the future of TechBio.
Meeting global leaders like Jamie who are humble and down to earth is such an inspiration: his
One of the feelings I love most is when pleasure coincides with struggle.
I’ve gone through seasons of feeling a lot of this and less of this in my life. Professionally, the most intense period was in the early days of building Recursion. It was so hard, and yet some of the best
Drug Discovery Yesterday: one-off, bespoke and almost artisanal...
This morning in our earnings we detailed:
+ New/tightened/accelerated clinical guidance
+ How we now combine LLMs with our proprietary maps of biology to initiate new drug discovery programs at
#BREAKING
: We bridged the protein and chemical space by predicting the protein target(s) for ~36 billion compounds in the
@EnamineLtd
REAL Space using
@nvidia
’s DGX Cloud and our own NVIDIA-based supercomputer, BioHive-1.
Learn more:
(1/3)
This is absolutely insane. Some of the most amazing colleagues I've worked with, who add to our country in many ways, who have helped shape and build Recursion, have been on H1B. We are directly causing the decline of American competitiveness if this is true...
I’m on an H1B visa. Every time I check in at an int’l airport to come back to the US, I find my stomach in knots. This is why. This is the nightmare scenario ⤵️⤵️⤵️ Business leaders: if you want to prevent a reverse brain-drain, now is the time to speak up!
@MichaelRetchin
What I thought would be hardest: science
What actually was hardest: people
Science has truth; people have truths.
Becoming an empathetic, inspiring leader of a fast-growing team, attracting and hiring the best & then getting the best out of them is hard (& still/always a WIP).
Look forward to connecting with everyone at JPM!
And if you haven’t gotten an invite to the awesome event we are co-hosting with NVIDIA, shoot me a DM and I’ll get one sent over!
We're gearing up for an exciting
#JPM24
next week! Help us kick things off with our Co-founder and CEO
@RecursionChris
's presentation on Monday, January 8 at 7:30 am PT.
We have a lot in store - you won't want to miss it!
#JPM2024
#TechBio
People ✅
Data ✅
Compute ✅
Capital ✅
Pulled the last pieces of plastic off of BioHive-2 today as we finish up our Top500 benchmarking work. HUGE thanks to the dedicated team
@RecursionPharma
for the incredible push to get this across the line… and a big thank you to our
Hey
#biotwitter
, I need your advice! My first in-person JPM presentation as CEO of a public company is Tuesday at
#JPM2023
, and I can’t make up my mind on my outfit?!? Any advice? A or B?
#bombcyclone2023
@davidbateman
@siliconslopes
Your comments offended our entire
@RecursionPharma
team as sponsors at
@siliconslopes
. Men and women. It brought down the awesome community we are building here. It made it harder for us to recruit. It wasn't a joke or an attempt at humor. Your non-apology doesn't help.
Reflecting on 2 milestones this AM - a transformational partnership with
@BayerPharma
& a substantial Series D financing. We are still just at the beginning of our mission to decode biology to radically improve lives, and so time to get back to work on the project of a lifetime!
So excited for
#JPM20204
next week, and in particular for the event we are hosting with
@nvidia
. The lineup is 🔥 🔥🔥!
You will see the CEO of NVIDIA, Jensen Huang, share the same stage as Life Science Luminaries like Aviv Regev (
@genentech
),
@ScottGottliebMD
and
Big welcome to Xaira - great to see the normalization of AI in drug discovery. A strong signal about the future. Great friends in
@ScottGottliebMD
, Alex Gorsky &
@rtnarch
at the helm. The next decade is going to be awesome in techbio!
Another transformational partnership for
@RecursionPharma
- this time w/
@Roche
/
@genentech
. All of neuro & 1 onc indication; ~1 decade; collaborating to build/explore maps of bio using -omics and
#ML
; targeting 40 new meds; 1 of the largest research collabs in biopharma history.
Today we announced a transformational collaboration with
@Roche
&
@genentech
to leverage technology-enabled drug discovery through the Recursion OS and more rapidly advance medicines in key areas of neuroscience and in an oncology indication. Read more:
My first time on CNBC today talking about our deal
@RecursionPharma
with
@nvidia
. Had a blast - thanks for having me Jon, Morgan and Mike! Looking forward to delivering on our new partnership, our existing partnerships and our Pipeline.
And thanks for the tips from two frequent
Recursion $RXRX popping 78% on deal with
#Nvidia
'We believe by leveraging tech, automation, the newest tools in bio & chem, we have an opportunity to really speed up pace & scale of drug discovery'," CEO Chris Gibson
$NVDA
@JonFortt
@MorganLBrennan
#AI
I’m so excited about the two acquisitions we are announcing today, which will be transformational for our chemistry capabilities
@RecursionPharma
. Both
@valence_ai
and
@Cyclica
are best-in-class AI drug discovery companies with incredible talent – I’m looking forward to meeting
#BREAKING
: We’re excited to announce we have entered into agreements to acquire
@valence_ai
and
@Cyclica
- two leading AI-enabled drug discovery companies - to bolster our chemistry and generative AI capabilities.
Learn more:
A proud day for our team: enrollment of our 1st ever ph2 trial and the 1st ph2 ever for CCM, a disease with no medical tx. We will push through any wall and face any challenge to bring medicines to patients, and we'll do it alongside the patient communities we aim to serve.
📢 NEWS 📢: Today we announced the enrollment of the first patient in our Phase 2 study of a potential treatment for Cerebral Cavernous Malformation. Read more:
@RecursionPharma
has partnered with a local Biosafety Level 3 facility to screen thousands of FDA-approved and Generally Recognized as Safe compounds in an unbiased, morphological, AI-enabled search for unexpected signals of efficacy against SARS-CoV-2 in primary human cells. 1/5
Great talk by
@genentech
’s Aviv Regev. Was disappointed not to see more biopharma folks at
#GTC2024
, but not surprised at all Aviv is here and speaking to standing room only!
Ecstatic to share this huge news - we want to lift up our team and create an incredible environment for each member to do their best work. This has been in the works for 3 years, and it is finally becoming a reality.
We are excited to announce today that Recursion will open an onsite
#childcare
center in partnership with
@BrightHorizons
to support working parents and ensure its people have access to convenient, affordable childcare. Learn more:
Big day for open-science at Recursion! Releasing a 2.2M image, 100TB genome-spanning CRISPR KO dataset* in primary human cells alongside a demo of one of our internal apps. Kudos to the team for getting this ready! Can’t wait to see what the community finds/builds on top of it!
We’re excited to release
#RxRx3
- our largest public dataset yet, along with
#MolRec
– a demo compound intelligence tool open for anyone to explore.
Both are built using a small subset (less than 1%) of our total data universe. DM us with any questions!
Wow - 18 new hires at
@RecursionPharma
start Monday. That's more than worked for the entire company at our Series A! Lots of incredible science to be done.
#growth
#hiring
UPDATE 6/6:
@Delta
didn't have a mechanism for me to give back the miles, so I've donated them (plus a matching chunk from my own miles) to
@BCRFcure
in honor of Breast Cancer Awareness and because finding cures for disease is what I dedicate my life to.
Congratulations to my mentor, co-founder and Board member at
@RecursionPharma
and friend, Dean Li, who was announced this morning to be replacing the otherwise inimitable Roger Perlmutter as head scientist at
@Merck
! Proud of you Dean!
We are hosting a TechBio Mixer Event in London on the evening of March 12th. We might have a surprise announcement planned as well!
In London and interested in connecting with others in the incredible community there? Shoot me a DM and I'll send you an invitation!
Proud to share that our first New Chemical Entity discovered and developed in-house by our team and the Recursion OS is headed into IND-enabling studies! It could soon join the 4 known chemical entities in our clinical-stage pipeline. Great work by the team!!!
We have initiated IND-enabling studies for REC-163964 for the possible prevention of C. diff infections. REC-163964 is the first internally-discovered NCE development candidate identified by the Recursion OS and advanced to IND-enabling studies.
6 hrs post our
@RecursionPharma
partnership news going public and 3 hrs post all-company meeting, & this is one of 4 teams with pizza at hand digging in already to deliver the future with our colleagues at
@Roche
and
@genentech
.
This is how we roll. Not a moment lost...
Hey
#TechBio
founders! I've been fielding lots of calls from you lately to think through some challenging situations - or just walking through various perspectives for you if it is your first-time through a certain thing as you build. I love spending that time with you, but it
Recursion has accomplished a LOT in the past 6 years, with more big announcements coming soon. But today is special - we're sharing something I am incredibly proud of: the opening of
@AltitudeLab
- a life science incubator brought to you by
@RecursionPharma
and the
@UofUTVC
.
Spent the morning with fellow Recursionauts in 🇨🇦 checking out offices for our new
#Toronto
/
#GTA
@RecursionPharma
hub! Can't wait to start hiring and building the Recursion Canada team. What an incredible, diverse, beautiful city!
Our mission at
@RecursionPharma
is to decode biology to radically improve lives. We will accomplish that by building a machine to industrialize drug discovery. Today, we announce our first acquisition -
@ViumInc
- to help us drive better medicines to patients faster.
Today, we acquired
@ViumInc
, a digital vivarium company, to bolster our efforts to industrialize
#DrugDiscovery
. This signals our continued and rapid integration of technologies to grow our pipeline of over 30 programs. Welcome to the team, Vium!
Interested in decoding biology to radically improve lives, AND 50" of pow pow 35 minutes away? Don't quit your job... join us
@RecursionPharma
. Life be like:🔬⛷🖥🏂📚🚴♀️📈🧗♀️💉🚵♀️
Super excited to announce Recursion Canada and our first multidisciplinary hub expansion into
#Toronto
! Talented, diverse people and a rapidly rising city are the perfect mix for tech-enabled drug discovery and for us! Many new positions opening there soon!
We’re excited to share our intention to launch our first major multidisciplinary expansion beyond our Utah HQ, with plans to hire up to 50
#Recursionauts
in Toronto by the end of 2021. Learn more:
@galenlittle
@RecursionPharma
1) I’ve invested in about 25 other TechBio companies (private) at much earlier stages who are taking really cool approaches very different from ours (including multiple founded by
#excursionauts
)
2) I have a handful of tech companies I like a lot and am invested in
3) I have some
Excited to share that we at
@RecursionPharma
have received Orphan Drug Designation from the FDA for our Familial Adenomatous Polyposis program. Proud to be working to bring a medical treatment to patients suffering from a disease with no approved therapeutic!
We’re proud to share that we received orphan drug designation from the FDA for REC-4881 for the potential treatment of Familial Adenomatous Polyposis. Learn more at
Excited for
@RecursionPharma
’s first Download Day in a few hours! Will be giving core investors, analysts and bankers a chance to meet our broader team, see the Recursion OS in action and get the latest on how we are leading technology enabled drug discovery!
Super excited to share three updates centered around the virtuous cycle of the Recursion OS:
Data (new
@TempusLabs
collaboration) -->
Compute (supercharing BioHive-1 with
@nvidia
) -->
Pipeline (pushing forward into precision oncology with
@Bayer
)
Leading the evolution of
Excited to announce three exciting updates together with
@NVIDIA
,
@Bayer
and
@TempusLabs
, Inc to support precision medicine, translation and trial design in
#oncology
. See more in the thread ⬇️ or our press release:
Today we announced the completion of our Phase 1 study for REC-3964 for Clostridioides difficile infection. REC-3964 was well tolerated with no reported serious adverse events.
Read more:
#Cdiff
#CDI
#Clostridioides
#difficile
#clinicaltrials
London TechBio community coming together in KX tonight hosted by
@RecursionPharma
and
@valence_ai
! Super excited to join up with so many incredible academics, startups, large tech companies, large bio companies and investors. Future feels very bright!
After our IPO & >8 yrs of building
@RecursionPharma
, I took time with family doing the thing that most helps me recharge - building things in nature (including sand castles)!
I am refreshed and ready to take on my role as the CEO of a newly public company.
What recharges you?
Check out this NBC News piece on our onsite childcare center at
@RecursionPharma
HQ in the
@BioHiveUtah
in Salt Lake City!
Fellow CEOs - are you taking similar steps to take care of your team so they can do the best work of their lives?
Our incubator
@AltitudeLab
launched its Investor Coalition this morning, convening 13 leading investors aiming to make $50 million in funding accessible to healthcare entrepreneurs over the next three years. Congratulations to
@Chandanananana
and the team!
You can now access one of our
@RecursionPharma
phenomics foundation models for methods development and other non-commercial use in partnership with
@nvidia
on BioNeMo!
[if you want to use the model for commercial purposes, contact our BD team!]
NVIDIA
#BioNeMo
, now features more than a dozen
#generativeAI
models, including Recursion’s Phenom-Beta model for target and hit discovery, accessed through cloud APIs for inference and customization.
Excited to share that
@RecursionPharma
is doubling down on 🇨🇦 & advanced
#AI
through a multi-year collab with
@Mila_Quebec
& our scientific advisor
#YoshuaBengio
!
We begin hiring AI researchers ASAP! I'm excited to dust off my French and spend time in Montréal & Toronto!
« Montréal, nous voici » Today we announced a multi-year collaboration with
@Mila_Quebec
. Together, we plan to build a team focused on using machine learning for tech-enabled drug discovery in Mila's Montreal office. Learn more: .
Doesn’t get much better than cooking on an open fire, glass of wine in hand, next to a beautiful flowing river, away from everything, with kids digging for worms and giggling in the background…
Nobody should have to choose between providing high-quality childcare to their kids & their profession. At
@RecursionPharma
, we made the investment so that our employees could decode biology to radically improve lives & know their kids are learning & growing in a special place.
We’re excited to announce our on-site child care center opened this morning. We are grateful to
@BrightHorizons
for running the center and providing top-tier care so our working parents can bring their best selves to work. Learn more at
The women's bag WAS definitely too big per the rules, but not meaningfully bigger than a dozen or so others belonging to other folks boarding the flight (none of whom were aggressively stopped). I can't say what motivated the agent, but it sure didn't pass my sniff test.
Exciting news! Can't wait to welcome friends, colleagues and the World to Salt Lake City. Count on an exciting party
@RecursionPharma
HQ during Winter Olympics 2034!
@sethbannon
Not quite a garage, but started
@RecursionPharma
in a conference room and a closet rented from
@UUtah
with ~$100K from the three founders and then filled it with used lab equipment we carted back in a
@uhaul
from defunct companies in California. Certainly agree this is a good way
When someone translated what happened to her, the women took all her cash out of her wallet, about $30, and humbly handed it to me, bowing deeply. She was clearly distraught and confused about what had happened, but glad it was over.
1/5. Facebook popped up this image from 6 years ago when
@blakeweb
and I filled a U-haul full of used, barely working lab equipment in San Diego, drove all night to Salt Lake to build out
@RecursionPharma
's first wet lab and start chipping away at our vision.
14 scopes wasn't enough to keep up with our team as we generate 1 of the largest relatable in vitro bio datasets on 🌎. Wonder what we'll call our 'factory of the future' producing massive multi-omic datasets across human biology at genome scale, small molecules and more? Ideas?
Reflecting back on
#JPM24
to a panel with Life Science Luminaries Aviv Regev (
@genentech
),
@ScottGottliebMD
&
@dramyabernethy
on
#TechBio
.
While the panel was too short, the consensus was clear: while there will be ups and downs over the near term as AI tools are deployed, the
As Co-Founder & CEO I’m honored that
@RecursionPharma
made
@Forbes
' list of America's Best Startup Employers. One of our top priorities is to recruit and retain top talent and I feel so privileged to work with our team everyday!
#Recursionauts
*NEWS*:
@Forbes
recognized us as one of America's Best Startup Employers. We aim to build a culture where people can do the best work of their lives — plus free, catered lunches don’t hurt. We’re hiring!
#Recursionauts
Partnering with the teams
@Roche
and
@genentech
has been fantastic. I love seeing the first of what I believe will be many milestones in this collaboration come so early in our work together.
Proud of the
@RecursionPharma
team for their strong work to get us here and excited by
We are excited to announce that our partner
@Roche
has exercised the Small Molecule Validation Program Option in a single area of oncology, representing a critical step in our joint efforts to initiate and advance new therapeutic programs.
Learn more:
First time I’ve been excited to order petunias. Now I just have to decide if we are going to plant them inside or outside?! Cool stuff
@light_bio
@Ginkgo
!
Want to decode biology to radically improve lives at the interface of robots, gene-editing, iPSC cells & CNNs at a company where you feel valued, have many opportunities for development & can be your authentic self?
70+ new positions up
@RecursionPharma
:
Welp, just signed up for an IronMan again. Been just over a decade since my last one - before Recursion…
Time to test myself.
I should probably buy a bike… any recommendations for tall dudes?
Excited to share a peek under the hood of the machine we are building
@RecursionPharma
. We share a handful of use cases in immunology and COVID. We also release 2 new datasets for a total of nearly 600k open-sourced images/embeddings totaling more than 1 TB! Enjoy!
We are excited to announce our preprint on functional immune mapping with deep-learning enabled
#phenomics
. Read the preprint online at and download the open-source datasets of another 200,000 6-channel images at .
Love the sound of 11
@moldev
scopes humming away on a Monday morning
@RecursionPharma
...
Nearly 10M perfectly labeled images of human cells /week, aggregated with 100s of M of prior images, all substrate for CNNs building the most comprehensive map of biology in history...
Super excited for this announcement today and privileged to get to work with and learn from incredible industry luminaries like James Sabry, Aviv Regev, William Pao and so many more!
Our transformational collaboration with
@Roche
&
@Genentech
in neuroscience and oncology may advance novel medicines to patients by using machine learning to map complex biology. Co-Founder & CEO
@RecursionChris
shares his thoughts on the collaboration.