Centre for Respiratory Science and Health
@RMIT_CRSH
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Multidisciplinary collaborations to develop new therapeutic strategies for people with respiratory diseases. Led by Prof Steven Bozinovski and @noxbiology
RMIT University
Joined July 2023
Have an interest in cutting-edge respiratory research? Want to initiate a collaboration? Check out our page for more information ⬇️ https://t.co/w7UKy36i5j
rmit.edu.au
A respiratory revolution in medicine
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Xinyue from @OXIBgroup is determining the role of CD4+ T cells in mediating vascular inflammation and dysfunction during gestational influenza infection
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Anh from Prof. Steven’s lab group is using a bioinformatics approach to identify potential therapeutic molecular targets in lung cancer
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Yutong from Prof. Steven’s lab group is developing lipid modulating therapeutic strategies for progressive sarcoidosis
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Ameanah from @OXIBgroup is exploring the lipdifferential temporal immune responses to influenza A virus and pattern recognition receptors stimulation in lung epithelial cells and macrophages
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Paneet from @OXIBgroup is investigating how prenatal and early life viral infections disrupt the blood brain barrier integrity and increase the risk of long-term neurodevelopment abnormalities
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Yesterday, we were thrilled to see several of our Centre’s PhD candidates present their latest groundbreaking discoveries at the RMIT Bridging Innovations in Health, Science and Technology Symposium!
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Congratulations to Dr Stella Liong and Dr Hao Wang for receiving the Outstanding Contribution to Research & Innovation (Early Career) and Certificate of Commendation, respectively. Their hard work was recognised today at @RMIT SHBS Staff Forum.
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Removing TLR7 reduced these sex-based differences, suggesting TLR7 may shape how males and females fight RSV. #RSV #TLR7 #Immunology #SexDifferences
https://t.co/2yG32o4muQ
mdpi.com
TLR7 plays a key role in recognizing viral RNA to initiate an immune response. Sex-based differences in the severity of RSV respiratory infections have been noted, and this may be related to higher...
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#ResearchSpotlight: New research led by @DrMark91 and @noxbiology from @OXIBgroup reveals TLR7 helps drive stronger immune responses to RSV infection in females, including higher cytokine and antibody levels. https://t.co/2yG32o4muQ
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It drives harmful lung inflammation and dysfunction early on but helps to control Th2-mediated chronic airway hyperreactivity. #Influenza #Immunology #TLR7
https://t.co/FjarO0EsHb
mdpi.com
Severe lower respiratory tract disease following influenza A virus (IAV) infection is characterized by excessive inflammation and lung tissue damage, and this can impair lung function. The effect of...
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#ResearchSpotlight: Research led by @DrMark91 and @noxbiology in collaboration with @UniversitySA and @TrinityCollege uncovers a double-edged role of TLR7 in influenza infections. 🦠
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In a two‐hit mouse model of COPD-asthma overlap (ACO), CD131 blockade reduced mixed granulocytic lung inflammation, airway hyperreactivity, emphysema, and fibrosis without impairing host antiviral immunity, highlighting CD131 as a therapeutic target. https://t.co/a4QaKJhZn2
onlinelibrary.wiley.com
This study presents a novel mouse model of ACO with asthma originating in early life. The pathobiological mechanisms driving airway hyperreactivity and lung remodelling in ACO involve both type 2...
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#ResearchSpotlight: Recent publication lead by Dr Hao Wang and our Centre director, Prof. Steven Bozinvoski, in collaboration with @UniMelb and @CSL.
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🌏Respirology CD131 antagonism blocks inflammation, emphysema and fibrosis in an #asthma-#COPD overlap mouse model originating in early life. A new research report published in #Respirology
https://t.co/RdjEdatXDq
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Our honours students presenting at the VIIN Young Investigator Symposium. Well done all! #viinyis #YoungVIIN2024 @The_VIIN @MIPS_Australia
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Our very own superstar Dr Mark Miles is an invited keynote speaker at the 2024 Northern's Brightest Stars Student Symposium, speaking on his career journey and his research program on unravelling the acute and chronic effects of TLR7 during respiratory viral infections.
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Big congratulations to @RMIT_CRSH Theme Leaders, @noxbiology and @RRG_Vlahos, for being recognised for their outstanding impact in research and inspirational leadership, respectively.
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Researchers led by Dr Simone De Luca in the Centre for Respiratory Science & Health @RMIT have discovered that targeting oxidative stress may be a novel strategy for managing COPD-related anxiety disorders. https://t.co/atUCCvbRxU
@RMIT_CRSH @alateeq_rana @antioxidants_OA
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Thank you @RRG_Vlahos, @ResearchRMIT, @RMIT_CRSH, @OXIBgroup, @noxbiology! A prominent mechanism that is often under appreciated!
State-of-the-art commentary by Dr Chan & Prof Selemidis on how focusing on precise cellular locations where oxidative damage is most detrimental and developing targeted miRNA-based therapies hold promise for treating muscle wasting in COPD and aging. https://t.co/wcxyT4wrut
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State-of-the-art commentary by Dr Chan & Prof Selemidis on how focusing on precise cellular locations where oxidative damage is most detrimental and developing targeted miRNA-based therapies hold promise for treating muscle wasting in COPD and aging. https://t.co/wcxyT4wrut
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