RENOVATE
@RENOVATEtrial
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#RENOVATE: Adaptive trial investigating the efficacy of #HFNC vs #NIPPV for #ARF. Funding: Brazilian Ministry Health, coordenated by #IPHCOR; NCT 03643939
São Paulo, Brasil
Joined June 2019
This is the official account of #RENOVATE trial where you will find news and updates on our study as well as content on adaptive trial design. Stay tuned! 😎.#bayesian #criticalcare #NonInvasiveRespiratorySupport #HFNC #NIV.
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The RENOVATE trial has wrapped up the 90-day follow-up for its final patient (LPLV). 💥In these couple of months, we've been working on data collection for completeness & data cleaning, followed by ➡️ database lock 🔒 & analysis! Stay tuned!.@israelmaia16.@leticiakawano.
💥 The #RENOVATEtrial is finished at 1.8k pts recruited, as per design. RENOVATE has no fixed sample size rather it had a sample size cap of 2k pts + triggers for success & futility analyzed by an independent DSMB. Huge thanks to pts, families, recruiting centers +
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RT @dfmcauley: @RENOVATEtrial @israelmaia16 @leticiakawano @BiasiAlexandre @FlaviaSepsis @otavio_ranzani @RogerJLewis That's great to hear.….
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2/ Thanks to the 🇧🇷 @minsaude (PROADI), our funder, @BerryConsultant for the amazing stats work, Fisher & Paykel for the donation of AIRVOs & #BRICNET for its support!. Kudos to the #Hcor coordination center team: 5y of hard work finalized w success . Stay tuned for the results!
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💥 The #RENOVATEtrial is finished at 1.8k pts recruited, as per design. RENOVATE has no fixed sample size rather it had a sample size cap of 2k pts + triggers for success & futility analyzed by an independent DSMB. Huge thanks to pts, families, recruiting centers +
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RT @israelmaia16: @UnityHealthTO @DrJohnCMarshall @ISARIC1 @AcuteCareTrials It was wonderful to participate in such an important meeting. I….
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#RENOVATEtrial reached an important milestone: 1,750 pts recruited 💥 triggering the last pre-planned interim analysis of the study!. Huge thanks to pts & families, recruiting centers, #Hcor team, @BerryConsultant, and our funder, the 🇧🇷 Ministry of Health (PROADI-SUS)
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RT @leticiakawano: 1/ 🚨 Publication alert at @CCRJournal:.Blinded update in the statistical analysis of the @RENOVATEtrial due to extraneou….
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RT @leticiakawano: @jacobosellares @ebarbetavinas @dfmcauley @bronwenconnolly @EA_gorman @israelmaia16 @Bram_Rochwerg @Crimillina Additiona….
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RT @leticiakawano: And hopefully in 2024 more data will come out from the @RENOVATEtrial on this important topic.RENOVATE has been recruit….
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RT @leticiakawano: Ping @RogerJLewis .So much learning to be working with @BerryConsultant in the @RENOVATEtrial and @REMAP_ILD .🤩.
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RT @israelmaia16: @RENOVATEtrial Proud to be part of this amazing team which has worked so well with many unexpected pandemic circumstaces….
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2/ If a particular threshold is met, the particular ARF subgroup is stopped (and/or the entire trial: all prespecified in protocol). Stay tuned. Our thank you to pts & families, recruiting centers, and the #HCOR research team, @israelmaia16 @leticiakawano, for the amazing work.
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1/ The #RENOVATEtrial reached an important milestone: 1,500 patients recruited, triggering an interim analysis. In this interim, it will be evaluated if thresholds for superiority and/or futility are met for each of the ARF subgroups (hipoxemic, APE, AE-COPD).
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#RENOVATEtrial has recruited 1,456 patients🎉. Based on trial simulations, RENOVATE is coming closer to the sample size where a conclusion may be reached (superiority, non-inferiority, futility). Stay tuned!. RENOVATE is an adaptive RCT led by @israelmaia16 & @leticiakawano
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RT @EA_gorman: A recent editorial in @JAMA_current @JAMANetwork highlighted an individual patient data network meta-analysis would help cli….
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RT @leticiakawano: I make Claudia's words my words. And kudos to @EA_gorman for pushing this challenging project forward!. Love to see rese….
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RT @leticiakawano: Critical Care research network part of the #RENOVATEtrial came to Sao Paulo today to discuss strategies to enhance recru….
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First in-person #RENOVATEtrial meeting with recruiting centers after 2 years. On the pic, #HCOR coordinating center team.@leticiakawano @israelmaia16 #AlexandreBiasi
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RT @dfmcauley: @RENOVATEtrial @israelmaia16 @leticiakawano @BerryConsultant @RogerJLewis @otavio_ranzani @EA_gorman @DarkNatter Wow. What a….
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