QBIpapers
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A feed from PubMed of papers by Queensland Brain Institute researchers. For other QBI news see @QldBrainInst. Image: Synaptic junctions by Anita Goldinger.
Brisbane, Queensland
Joined June 2015
Neurodesk: an accessible, flexible and portable data analysis environment for reproducible neuroimaging
pubmed.ncbi.nlm.nih.gov
Neuroimaging research requires purpose-built analysis software, which is challenging to install and may produce different results across computing environments. The community-oriented, open-source...
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Mapping the dynamics of visual feature coding: Insights into perception and integration
pubmed.ncbi.nlm.nih.gov
The basic computations performed in the human early visual cortex are the foundation for visual perception. While we know a lot about these computations, a key missing piece is how the coding of...
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Magnetogenetic stimulation inside MRI induces spontaneous and evoked changes in neural circuits activity in rats
pubmed.ncbi.nlm.nih.gov
The ability to modulate specific neural circuits and simultaneously visualize and measure brain activity with MRI would greatly impact understanding brain function in health and disease. The combin...
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Perineuronal nets are associated with decision making under conditions of uncertainty in female but not male mice
pubmed.ncbi.nlm.nih.gov
Biological sex influences decision-making processes in significant ways, differentiating the responses animals choose when faced with a range of stimuli. The neurobiological underpinnings that...
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Modeling how antibody responses may determine the efficacy of COVID-19 vaccines
pubmed.ncbi.nlm.nih.gov
Predicting the efficacy of COVID-19 vaccines would aid vaccine development and usage strategies, which is of importance given their limited supplies. Here we develop a multiscale mathematical model...
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Single-session reproducibility of MR spectroscopy measures of glutathione in the mesial temporal lobe with MEGA-PRESS
pubmed.ncbi.nlm.nih.gov
The data suggest measures of abundant metabolites in the MTL using the MEGA-PRESS sequence has a high reproducibility. Reproducibility of GSH in this area was poorer requiring care when interpreting...
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Toward hippocampal volume measures on ultra-high field magnetic resonance imaging: a comprehensive comparison study between deep learning and conventional approaches
pubmed.ncbi.nlm.nih.gov
The hippocampus is a complex brain structure that plays an important role in various cognitive aspects such as memory, intelligence, executive function, and path integration. The volume of this...
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Phospholipase Modulation of Synaptic Membrane Landscape: Driving Force Behind Memory Formation?
pubmed.ncbi.nlm.nih.gov
The synapse is the communication unit of the brain, linking billions of neurons through trillions of synaptic connections. The lipid landscape of the synaptic membrane underpins neurotransmitter...
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Whole-Brain Electrophysiology in Drosophila during Sleep and Wake
pubmed.ncbi.nlm.nih.gov
Sleep studies in Drosophila melanogaster rely mostly on behavioral read-outs to support molecular or circuit-level investigations in this model. Electrophysiology can provide an additional level of...
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Whole-Brain Calcium Imaging in Drosophila during Sleep and Wake
pubmed.ncbi.nlm.nih.gov
Genetically encoded calcium indicators (GECIs) allow for the noninvasive evaluation of neuronal activity in vivo, and imaging GECIs in Drosophila has become commonplace for understanding neural...
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Whole-Brain Electrophysiology and Calcium Imaging in Drosophila during Sleep and Wake
pubmed.ncbi.nlm.nih.gov
Sleep is likely a whole-brain phenomenon, with most of the brain probably benefiting from this state of decreased arousal. Recent advances in our understanding of some potential sleep functions, such...
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Deep Brain Stimulation for Obsessive-Compulsive Disorder: Optimal stimulation sites
pubmed.ncbi.nlm.nih.gov
Our results suggest how to refine targeting of DBS in OCD and may be helpful in guiding DBS programming in existing patients.
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Normative Modeling of Brain Morphometry Across the Lifespan Using CentileBrain: Algorithm Benchmarking and Model Optimization
pubmed.ncbi.nlm.nih.gov
We present an empirically benchmarked framework for sex-specific normative modeling of brain morphometry that can inform about the biological and behavioral significance of deviations from typical...
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Chronically high stress hormone levels dysregulate sperm long noncoding RNAs and their embryonic microinjection alters development and affective behaviours
pubmed.ncbi.nlm.nih.gov
Previous studies on paternal epigenetic inheritance have shown that sperm RNAs play a role in this type of inheritance. The microinjection of sperm small noncoding RNAs into fertilised mouse oocytes...
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Global quantitative proteomic analysis of aged mouse hippocampus
pubmed.ncbi.nlm.nih.gov
Understanding the molecular changes associated with the aged brain forms the basis for developing potential strategies for slowing cognitive decline associated with normal aging. Focusing on the...
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Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism
pubmed.ncbi.nlm.nih.gov
Macrophages regulate metabolic homeostasis in health and disease. Macrophage colony-stimulating factor (CSF1)-dependent macrophages contribute to homeostatic control of the size of the liver. This...
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The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders
pubmed.ncbi.nlm.nih.gov
Complement components have been linked to schizophrenia and autoimmune disorders. We examined the association between neonatal circulating C3 and C4 protein concentrations in 68,768 neonates and the...
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CSF-1R inhibitor PLX3397 attenuates peripheral and brain chronic GVHD and improves functional outcomes in mice
pubmed.ncbi.nlm.nih.gov
Graft-versus-host disease (GVHD) is a serious complication of otherwise curative allogeneic haematopoietic stem cell transplants. Chronic GVHD induces pathological changes in peripheral organs as...
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'10th cell architecture in development and disease (CADD)': Meeting report
pubmed.ncbi.nlm.nih.gov
'10th cell architecture in development and disease (CADD)': Meeting report
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Human-derived air-liquid interface cultures decipher Alzheimer's disease-SARS-CoV-2 crosstalk in the olfactory mucosa
pubmed.ncbi.nlm.nih.gov
The study sheds light on the interplay between AD pathology and SARS-CoV-2 infection. Altered transcriptomic signatures in AD cells may contribute to unique symptoms and a more severe disease course,...
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