Heading to Summer #RosettaCon 2025 hosted by @RosettaCommons?. Our Head of Protein Design @jeffruffolo is chairing the panel Protein Language Models: Power and Limitations of Scaling for Structure, Function, and Design at 8:45am PT on Tues, Aug 5. You can also catch Jeff on the

Our thanks to @xiaofei_lin at @GENBio for speaking with @thisismadani and @HilaryEaton14 about yesterday’s peer-reviewed publication of OpenCRISPR-1 in @Nature, the future of LLM-based design of gene editors, and the impact we’ve already seen following OpenCRISPR-1’s widespread.

Learn more:.🔗 Press release: 🔗 Nature paper:

We’re excited to share new data published in @Nature detailing the impressive activity, specificity, and low immunogenicity of our AI-designed CRISPR-Cas proteins, including OpenCRISPR-1. The future of gene editing is here and we’re scaling our capabilities to tackle the

AI is shaping the future of protein design and unlocking new possibilities in medicine, agriculture, and materials science. @thisismadani spoke with Geoff Carr of @TheEconomist about how Profluent is using LLMs to make biology programmable. Read more:

Next week @thisismadani joins #AIxBio25, hosted by @ConnectingSci @eventsWCS, to explore scaling benefits in protein design in his talk, “Scaling Foundation Models for Protein Generation.”. Learn more:

If that sounds like you, check out our openings:

We welcomed summer (a little early) with a picnic and a few rounds of Uno. Uno may be polarizing, but we think it brings out the best in us, with a bit of fun, fierce competition, and some lively debate about house rules. In fact, these are the values that fuel our work daily.

We're heading to #BIO2025 in Boston (June 16-19)!. Our CEO @thisismadani and CBO @HilaryEaton14 will be representing Profluent onsite and are eager to connect with fellow industry leaders and discuss the future of this exciting field. Let’s collaborate!

Register here:

On June 16, @HilaryEaton14 will join @jenasherphd of @1910Genetics and Martin Gomez, Sarah Solomon and Robert Carroll of @goodwinlaw on a “Diligence Considerations with Tech Acquirers and IP Risks from AI in Drug Discovery and Development” panel during #BIO2025.

@HilaryEaton14 Register here:

Profluent will be at #TIDESUSA in San Diego next week! Join us on May 19-22, 2025 and drop us a line to connect. @HilaryEaton14 will be onsite to discuss how partners can license our molecules and models to tackle the most challenging protein design problems.

Register here:

Make sure to catch @thisismadani at #PEGSSummit next week for a talk titled, “Scaling Foundation Models for Protein Generation,” on Thursday, May 15 at 4:30pm PT to investigate scaling effects and molecular design applications for our latest foundation model suite, ProGen3.

Attending the @ASGCTherapy’s #ASGCT2025 next week?. Meet with our CBO @HilaryEaton14 to explore how we can build together.

Register here:

At #SynBioBeta2025, @thisismadani will join a panel titled, "AI-Powered Biological Design: Breaking Barriers or Hitting Limits?", with @BrianHie, @julian_englert, and Esteban Toro to explore the evolving landscape of AI in biological design.

Sign up here to join:

We’re opening early access to ProGen3 for select users. For your protein engineering needs, are you looking to generate a new starting point or optimize a given sequence?. Check out our instructional video below.