📢 Precision Clinical Medicine’s 2024 Impact Factor is 5.0 (5-Year IF: 4.4). Grateful to our authors, reviewers & editorial board for advancing the field of precision medicine. 🔗

A deep learning model (VB-MrFo-Net) uses CT images to non-invasively predict the prognosis of clear-cell renal-cell carcinoma (ccRCC). It's a crucial step for patient care.

Functional enrichment analysis showed DNA repair and RNA splicing pathways are linked to prostate cancer through ferroptosis, offering new insights into the disease's mechanisms.

The lesion pair relation estimation (PRE) model outperforms clinicians at this difficult task. Model AUC was 0.793, while two experienced clinicians scored 0.619 and 0.580.

Precision medicine is needed to identify highly invasive pure solid T1 lung cancer. This review provides key insights for tailoring future diagnostic and therapeutic strategies.

The combined model, integrating radiomic features with clinical data (age, sex, LN diameter), achieved excellent discriminatory ability with an AUC of 0.92 in the validation set.

Higher tertiary lymphoid structure (TLS) density correlates with significantly better overall survival in colorectal cancer patients, as demonstrated across multiple cohorts. HR for high vs. low is 0.57.

Accurate prediction of myopia progression and high myopia risk provides valuable insights for personalizing and optimizing the clinical management of myopia in children.

Integrating multi-modal data significantly enhances the predictive accuracy for breast cancer prognosis, offering a promising tool for personalized treatment strategies.

For psoriatic arthritis, Lactococcus, Akkermansia, and Coprococcus 1 were identified as risk factors. Odoribacter and Rikenellaceae were found to be protective.

The gut-muscle axis just got clearer. A Mendelian randomization study shows a causal association between specific gut microbiota and sarcopenia-related traits like low hand-grip strength.

Researchers confirmed the diabetes-alleviating effect of Faecalibacterium prausnitzii in a mouse model, providing strong evidence for its role as a potential therapeutic target.

A rare case of small intestine sarcomatoid carcinoma (SISCA) with metastases shows a favorable response to multidisciplinary treatment. This may guide future therapeutic strategies.

By targeting SOCS2, miR-181b activates key signaling pathways, including epithelial-mesenchymal transition (EMT). This provides a detailed look at how the cancer becomes more invasive.

High APOA1 levels are associated with reduced tumor proliferation and a favorable immune response in the tumor microenvironment (TME), including a positive correlation with anti-tumor immune cells.

A comprehensive description of ASCP’s genomic landscape provides a molecular basis for new therapeutic strategies for this difficult-to-treat malignancy.

Researchers identified common gene alterations in ASCP, including high rates of KRAS and TP53 mutations. These findings shed light on the aggressive nature of the disease.

Research on CAR-T therapy targeting claudin18.2 shows robust anti-tumor capabilities in gastric cancer. It may be the future of treatment.

Fecal lactoferrin trajectories predict endoscopic, clinical, and histological remission in ulcerative colitis patients. This discovery may help clinicians stratify patients for personalized care.

Spleen tyrosine kinase (Syk) expression is elevated in inflamed tissues and neutrophils of ulcerative colitis patients. This discovery links Syk to disease activity and inflammation.

Researchers found that MyD88 suppression leads to unfavorable changes in gut microbiota composition, including a higher abundance of Proteobacteria. This may activate a different immune pathway.