Overall, the KDPI's approach is flawed. Instead of telling patients ‘this kidney is in the bottom 20% of all kidneys’, we need to talk about meaningful outcomes. ‘Its likely the kidney will be working and you’ll be alive in 3 years.” The KASI enables that approach. @ParisTxGroup

We show how the addition of recipient variables to the baseline model drives major gains in discrimination & calibration. More importantly, the kidney allograft survival index (KASI) grounds outcomes in what matters: graft survival. @VUMChealth @PennLDI https://t.co/rUcDIox9ri

Let's fix this. Predictive modelling developed rapidly over 2 decades. Now everyone accepts that a good model has high discrimination and calibration, overall and in subgroups. Only recently did it become clear how atrocious the KDPI’s calibration is. @UNOSNews @AST_info

New research insights! A central transplant problem is successful organ allocation, which depends on accurate prediction of how organs will perform after transplant. We allocate kidneys using the kidney donor profile index (KDPI). Yet, KDPI accuracy is worse than anyone knew.

Kudos to this great team for new insights into an old problem. Changing allocation is a challenge - but transplant leaders can do it with persistence and a hard look at the data. @UNOSNews @PennLDI @AST_info @JAMA_current

Exciting results published in JAMA reveal how organ allocation could be modified to reduce EBV risks for children needing kidney transplants. There are enough EBV-negative kidneys to meet the needs of kids with end-stage kidney disease.

Managing infections transmitted by the organ donor is a major challenge for transplantation. Vishnu Potluri's group already made major insights into how the field underestimated risks of EBV and post-transplant lymphomas - & changed practice for EBV-negative waistlisted patients

And this one tackles transplant policy with a global lens. Spread the word to trainees! Policy Innovations to Advance Equity in Solid Organ Transplantation July 25 – 10:00 AM (EDT) Speakers: Elmi Muller, Peter Reese, Lisa McElroy, Jennifer Li (Chair) https://t.co/7byOzrwG2s

And this one will be awesome too. Advancing Patient Monitoring, Diagnostics, and Treatment Strategies for Transplant Precision Medicine 📅 July 17, 2025 – 8:00 AM (EDT) https://t.co/nYY9Cus82c 👥 Speakers: Alex Loupy, Marta Sablik, Peter Reese, Jennifer Li (Chair) @ParisTxGroup

Fascinating webinar - open access! Scientific Advances in the Assessment, Modification, and Generation of Transplantable Organs for Patients with End-Stage Organ Diseases 📅 July 7 – 1:00 PM (EDT) 🔗 https://t.co/Dsxdqva6a4 Matt Bacchetta, Ciara Shaver, Camille Kotton

Organ transplantation can save lives. 🫁 However, challenges remain, including organ shortages and unequal access. A new Series, presented at #ESOT25, explores promising opportunities to address these challenges. Read now: https://t.co/wuX1h7nyF3

🔬 Just published in @TheLancet: a new Clinical Series on Solid Organ Transplantation, co-authored by experts around the globe. 📖 Read the full Series: https://t.co/pLytYBvceJ Thread below 👇 #ESOT2025 @AlexandreLoupy @MartaSablik @PeterPReese1 @KiranKhush1

The field of transplant should commit to making this amazing therapy available to all who need it. Congratulations to Drs Jauré, Jha, McElroy, Muller, Oniscu, Serper, Purnell and Scholes-Robertson. @ESOTtransplant @AST_info https://t.co/4yfdwzJ6Yr

Advances in precision immunosuppression will protect transplant recipients from immunosuppression’s toxicities. When the organ does suffer injury, new deep phenotyping tools will tell us why. Congratulations to Alex Loupy, Marta Sablik and Kiran Khush.

Incredible innovations will bring more organ transplants to more people and those organs will be able to travel further and function better. Congratulations to Drs Shaver, Bacchetta, Griesemer and Zuckermann. @ttsorg @VUMChealth https://t.co/61hYOvoUxd

Very exciting day - a group of exceptional scientists will publish a 3-part positive vision for the future of solid organ transplantation. These manuscripts will be open-access and accompanied by 3 webinars supported by @TheLancet @AST_info @ESOTtransplant @ttsorg @ParisTxGroup

I can't wait to get to London for ESOT Congress 2025. The meeting will certainly feature new, important scientific developments. I am also fired up by fresh international collaborations designed to chart a bright future for patients with end-stage organ disease. @ESOTtransplant

I see progress in figuring out how to guide immunosuppression toward individual patients' needs Amazing work here by Alex Loupy’s group illuminating how cell-free DNA reveals allograft inflammation, but a clinician needs to interpret in the clinical context. @AlexandreLoupy

Want to learn how the management of solid organ transplant recipients is being transformed by new technologies? Come to this free webinar! Led by the amazing Alex Loupy and rising star Marta Sablik. @ParisTxGroup @ESOTtransplant @thelancet

We need trials + AI based analysis to integrate biomarker data + learn how to customize the right immunosuppression meds + intensity for each patient. July 1 - we’ll offer an optimistic vision of that patient-centric future. @ast_info @ParisTxGroup @AlexandreLoupy @KiranKhush1