Welcome to the official account of Pharmacology, Biochemistry and Behavior, a Journal from @ELSneuroscience @ELSpharma. Here you can find updates, call for papers, news about special issues, and interesting research findings. Let's talk about #Neuroscience and #pharmacology!.

Current #depression treatment: outdated? 🧐.Preclinical studies have shown that MCH receptor 1 antagonists have rapid-onset #antidepressant efficacy. ⚡️ This review analyzed the modulating role of melanin-concentrating hormone in depression. Learn more:

🧠 Youth with #ADHD process info faster, but less accurately, especially in recognition memory tasks. New study explores how stimulant treatment and stimulus type affect memory, impulsivity, and decision-making. 📊 Faster ≠ better?.🔗 Read more:

📢New study! 🚀 Emilio Ambrosio's team at UNED studied plasma alterations in a model of craving incubation after cocaine and alcohol co-self-administration in young adult male and female rats. @UNEDPsicobio @garridomatilla.#Addiction #Cocaine #Alcohol.🔗

🚬How does #nicotine affect movement? .🪱A new study from @SWIRLswanseauni (@SwanseaMedicine) examines its impact on Lumbriculus variegatus locomotor behavior🔬 Research by @nadavies87 @julanta3, Annie, Aneesha, Lisa & @ASeeleySUMS, funded by @SDMFWales.🔗

🧠 Boosting brain plasticity with AMPAkines! These AMPA receptor modulators enhance synaptic plasticity & show promise for treating neurological & psychiatric disorders like ADHD, depression, & spinal cord injury. 🔗 #SynapticPlasticity #Pharmacology.

🤔Is it time to re-think #OCD pharmacotherapy?.Discover how Levomilnacipran could theoretically offer a safer, effective alternative to clomipramine for obsessive-compulsive disorder. To learn more: .#Pharmacotherapy #MentalHealth #neuroscience.

#EditorsSpotlight 🔦🔦#exercise boosts memory, but how late is too late? This study shows that a 30-min run 11h after learning enhances long-term memory persistence in rats! 🐀💨 Protein synthesis & neurotransmitter systems are key players. Learn more:

Addiction is reward gone wrong—where drug rewards overpower natural reinforcers. This #SpecialIssue explores how reward dysfunction contributes to substance use disorders (SUD), covering neuroadaptations, assessment methods, and treatment implications. 🧠.

#EditorsSpotlight 💡.🎰 Chronic uncertainty during #gambling may alter the brain’s arousal signals—shifting from cues for caution to indicators of potential reward. 🚨➡️💰 This shift could drive risky behaviors in people with gambling disorder (PGD).

This study conducted in adolescent #cannabis users suggests that greater distress intolerance and lower glutathione levels might reflect alterations in the balance between protective and oxidative stress conditions. 🧠.#Neuroscience.To learn more:

RT @NatRevNeurosci: Remission from addiction: erasing the wrong circuits or making new ones? — a Perspective by Michel Engeln & Serge H. Ah….

Are multi-omics 🧬 the future towards more effective and personalized therapies for #mood and #anxiety disorders? 🤔.Read more: #Neuroscience #Genetics #PersonalizedMedicine.

Neuropeptides like corticotropin-releasing hormone and arginine-vasopressin are emerging as therapeutic targets. With continued research, they may redefine anxiety treatments and improve countless lives. 🌟. Read the full review for insights! 👇.

This review explores the role of neuropeptides in anxiety management:.🧬 Neuropeptide Y: Critical in modulating anxiety-related behaviors. ⚡ Substance P: Activates neuronal signaling in anxiety disorders. 🧪 Cholecystokinin: Plays a pivotal role in anxiety conditions.

💡#EditorsSpotlight🚨.Anxiety disorders disrupt lives with overwhelming worry and fear. While current treatments focus on SSRIs, benzodiazepines, and beta-blockers, new hope lies in neuropeptides—key regulators of complex behaviors. 🧠✨

How are sex and age related to the anxiolytic effects of alcohol? 🍷.This commentary highlights the need of further research for improving the understanding of how these factors influence this critical health issue. To learn more: #alcoholawareness.

Lack of sleep 💤 caused by misalignment of circadian rythms ⏰, chronic restriction and sleep disorders have consequences leading to a facilitated substance use disorder. Learn more about the role of #anxiety in drug intake:

This #EditorsSpotlight is part of the 50th Anniversary Special Issue. 🎊.Jeffrey Witkin and James Barrett present an overview which provides a historical introduction to the discovery of #anxiolytics and discuss the need for anti-anxiety medications. 💊.

Research from @SamHoustonState and @UF report that an 8-day probiotic regimen in Black Australorps🐔 produce anxiolytic effects and the combination of #probiotics 🦠 and #fluoxetine 💊attenuate these effects. To learn more: