
Nicolas Duployez
@NicolasDuployez
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#leusm #AMLsm #MDSsm molecularist & #Blood cytologist 🔬/ #Myeloid neoplasms and #germline disorders / #Hematology department @CHU_Lille @univ_lille
Lille, France
Joined March 2019
How I classify #AML in 2023 😱 WHO & ICC 👉diagnosis (AML entities) ELN 👉 prognosis (fav vs. int/adverse) #cytology + #mutations + #cytogenetics 🔬🧬
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Tips de rentrée > 🩸 Les bases du diagnostic de leucémie aiguë : 🔬 un laboratoire compétent 🤓 un cytologiste de qualité #Leucémie #Hématologie #Diagnostic
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#CHIP Drives Increased Mortality Unaltered by CAD Interventions | ASH Clinical News | American Society of Hematology
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Under-48-hour #RapidNGS is turning “wait a week” into “treat today.” ⚡️🧬 Same run → DNA RNA, on-the-spot FLT3/IDH calls, real-time #myeloMATCH trial slots, and a fighting chance for aggressive AML.Precision moves fast—so must we.happening at Fortis!!!! @RahulDoc2 @nikhil91sjmc
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LS arises rapidly after immune-targeted therapy, highlighting the importance of enhanced methods of detection and treatment. https://t.co/5IFpnpJVbv
#immunobiologyandimmunotherapy #lymphoidneoplasia
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🚨 Just published! 🧬 The #genomic landscape of #AML: redefining classifications, ontogeny, and therapeutic strategies 👉 Download here: https://t.co/zL99OiH9Wy
#leusm #AMLsm #Genomics #Hematology
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🚨 Just published! 🧬 The #genomic landscape of #AML: redefining classifications, ontogeny, and therapeutic strategies 👉 Download here: https://t.co/zL99OiH9Wy
#leusm #AMLsm #Genomics #Hematology
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Myeloid Neoplasms With Erythroid Predominance and Excess Blasts in Young Adults 👉enriched in NPM1 (FLT3wt) and UBTF mutations. 🔬🧬Morphology guides, but mutations define the diagnosis of AML. #leusm #AMLsm @LaureneFenwarth @benjamin_podvin
https://t.co/Hex9tE2aT9
onlinelibrary.wiley.com
The evolution of acute myeloid leukemia (AML) classifications has progressively shifted the diagnostic focus toward genetic criteria. Nevertheless, morphology remains a key element in clinical...
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🩸 IDH1/2 mutations in intensively treated #AML: ➡️ NPM1 & DNMT3A co-mutations drive prognosis. ➡️ IDH1/2 persistence in remission does not predict progression. #leusm #AMLsm 🎉@LaureneFenwarth
nature.com
Blood Cancer Journal - Disease characteristics and monitoring of IDH1/IDH2-mutated acute myeloid leukemia
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Disease characteristics and monitoring of IDH1/IDH2-mutated acute myeloid leukemia @BloodCancerJnl
https://t.co/ZIxQaEIXML
nature.com
Blood Cancer Journal - Disease characteristics and monitoring of IDH1/IDH2-mutated acute myeloid leukemia
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Very happy to share our work on therapy-related myeloid neoplasms (t-MN) post-CD19 CAR T-cell therapy, published in @LeukemiaJnl and involving 4 French centers (@CHU_Lille, Lyon, Caen, St-Étienne). 🔗 https://t.co/lVrcI9P1B7
#CAR_T #Lymphoma #tMN #Hematology
nature.com
Leukemia - Myeloid neoplasms after CD19-directed CAR T cells therapy in long-term B-cell lymphoma responders, a rising risk over time?
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PFMG2025–integrating genomic medicine into the national healthcare sys...
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#HappyNewYear2025 #Hematology Proud of our team at @CHU_Lille , dedicated to the molecular biology of hematological malignancies, who gave their best throughout 2024. THANKS to all of you! 🙌 Ready to take on new challenges in 2025!
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Previous studies have shown self-reported Black patients have inferior treatment and survival outcomes compared to White patients, but why? Our work indicating that underlying genetics influence AML biology is now live at @NatureGen! 🎉🎈🍾
nature.com
Nature Genetics - Analysis of exomes and transcriptomes from 100 African American patients with acute myeloid leukemia identifies ancestry-related variation in mutation profiles and survival....
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📍ELN 2017/2022 prognostic classifiers did not adequately stratify OS outcomes for #AMLsm patients treated with VEN-based regimens. 📍A 4-gene prognostic model (TP53, FLT3-ITD, NRAS, and KRAS) stratified OS outcomes with VEN-AZA treatment in #AMLsm. https://t.co/MOhsy4d6bk
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ELN-risk classification for #AMLsm patients receiving less-intensive therapies (ELN 2024 Less-Intensive) https://t.co/CJKiQGCicE
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Les patriarches hospitalo-U qui ne jurent que par leur H-index sont le cancer de la profession : Lettre hallucinante de l'ANPGM qui demande à ce que la loi ne soit pas appliquée car des personnes sans le diplôme veulent apparaître sur les compte rendus !!
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