My Neuropath News
@NeuropathClinic
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Dr Iban Aldecoa, neuropathologist at Hospital Clinic of Barcelona and Brain Bank-IDIBAPS. I just tweet articles of Neuropath and Neuroscience. All views my own.
Catalonia, Spain
Joined January 2018
A foothold in detection of limbic-predominant age-related TDP-43 encephalopathy #neuropath
https://t.co/GQEDYUXhvx
academic.oup.com
The field of neurodegenerative disease is transforming. Disease definitions and classifications are increasingly being based on biology rather than clinica
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A probabilistic histological atlas of the human brain for MRI segmentation https://t.co/oAAvj0BBDH
nature.com
Nature - NextBrain is an open source, probabilistic atlas of the entire human brain, assembled using artificial-intelligence-enabled registration and segmentation methods to reconstruct the...
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Anatomical progression of genetic frontotemporal lobar degeneration across the lifespan #neuropath
https://t.co/L0jWzWXzt5
academic.oup.com
Using brain charts that map structural changes in the brain across the human lifespan, Planche et al. estimate the neurodegenerative trajectories of the th
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Neuropathology of Lewy body dementia: Lewy-related pathology, α-synuclein oligomers, and comorbid pathologies #neuropath
https://t.co/t3JZdgSq9G
molecularneurodegeneration.biomedcentral.com
Lewy body dementia is the second most common form of neurodegenerative dementia, following Alzheimer’s disease. This umbrella term encompasses dementia with Lewy bodies (DLB) and Parkinson’s disease...
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Diffusely metastatic glioblastoma with FGFR3::TACC3 fusion: cell-free DNA fragmentation analyses and molecular characterization of matched primary and metastatic tumor sites #neuropath
https://t.co/Vh6gmWNRpJ
actaneurocomms.biomedcentral.com
Extracranial metastasis of IDH-wildtype glioblastoma is very rare and poorly understood at the molecular level. We report a case of FGFR3::TACC3 fusion IDH-wildtype glioblastoma in a 61-year-old...
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Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease https://t.co/7MiGxwjJwG
academic.oup.com
In a large, multicentre study using tau-PET and post-mortem data from individuals with five clinical variants of Alzheimer's disease, de Bruin et al. show
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Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease #neuropath
https://t.co/un9HJIh2du
onlinelibrary.wiley.com
Objective Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α-synuclein in the brain. Neuroinflammation has long been implicated in LBD...
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Digital neuropathology of neurodegenerative disorders: Foundations, research advances, and future directions #neuropath
https://t.co/f9L8wShVYG
alz-journals.onlinelibrary.wiley.com
A neuropathology examination after death remains the gold standard for differentiating between Alzheimer disease (AD) and AD and related dementias (ADRD). Increasing interest and familiarity with...
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Employing nanopore sequencing on FFPE-derived DNA for CNS tumor diagnostics #neuropath
https://t.co/NFDS4JeWIo
actaneurocomms.biomedcentral.com
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Rethinking neurodegeneration through a co-proteinopathy lens #neuropath
https://t.co/xv7qKof1nS
cell.com
Neurodegenerative diseases have long been considered distinct proteinopathies: amyloid-β and tau in Alzheimer’s disease, α-synuclein in Parkinson’s disease, and TDP-43 in amyotrophic lateral sclero...
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PolyGR-containing aggregates link with pathology and clinical features of Alzheimer’s disease #neuropath
https://t.co/VEFLeH0Fuj
link.springer.com
Acta Neuropathologica - Alzheimer’s disease is the most common form of dementia; however, its molecular mechanisms are not fully understood. We recently identified...
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Low-grade diffusely infiltrative tumor, SMARCB1-mutant: A diagnostic challenge—case report #neuropath
https://t.co/hoHXo7VyVg
academic.oup.com
To the Editor:
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A rare case of atypical teratoid rhabdoid tumor (AT/RT) with homozygous SMARCB1 loss and one concurrent somatic heterozygous SMARCA4 variant #neuropath
https://t.co/3RGGcEdKwU
actaneurocomms.biomedcentral.com
Atypical teratoid rhabdoid tumors (AT/RT) are characterized by a poor prognosis and a manifestation within the first 2 years of life. Genetic hallmark of these tumors is the homozygous inactivation...
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Path2Omics Enhances Transcriptomic and Methylation Prediction Accuracy from Tumor Histopathology https://t.co/wOpQySAaSp
aacrjournals.org
Abstract. Precision oncology is becoming increasingly integral to clinical practice, demonstrating notable improvements in treatment outcomes. While molecular data provide comprehensive insights,...
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Alpha-synuclein deposition patterns in Alzheimer’s disease: association with cortical amyloid beta and variable tau load #neuropath
https://t.co/d1ObTxi75V
link.springer.com
Acta Neuropathologica - Alpha-synuclein (α-syn) deposits are common in around half of the Alzheimer’s disease (AD) cases. While direct and indirect protein interactions are suggested,...
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White matter changes in Alzheimer's disease: contributor, consequence or co-pathology? https://t.co/idgbHIibZp
academic.oup.com
This scientific commentary refers to ‘Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer’s disease’ by Pescoller et al
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Neuropathologic Changes in People With Essential Tremor With Dementia. A Postmortem Study #neuropath
https://t.co/LKKTMCFRCU
neurology.org
Background and ObjectivesProspective cohort studies have demonstrated elevated risks of incident dementia in patients with essential tremor (ET). The explanation for this enhanced risk of dementia in...
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Integrated transcriptomic landscape of medulloblastoma and ependymoma reveals novel tumor subtype-specific biology #neuropath
https://t.co/sBKNIpyl4c
academic.oup.com
AbstractBackground. Medulloblastoma and ependymoma are common pediatric central nervous system tumors with significant molecular and clinical heterogeneity
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Shared burden of ultra-rare genetic variants across a spectrum of motor neuron diseases https://t.co/tubg1hSVd2
translationalneurodegeneration.biomedcentral.com
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Barcelona Progressive Supranuclear Palsy (PSP) Registry: Clinical, Oculomotor, and Cerebrospinal Fluid Markers; from Suggestive to Definite Cases #neuropath
https://t.co/mnBxswm5ol
movementdisorders.onlinelibrary.wiley.com
Background Timely and accurate diagnosis of progressive supranuclear palsy (PSP) remains challenging. Objective To assess diagnostic certainty and progression biomarkers in the PSP spectrum from “...
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