NanoFCM
@Nano_FCM
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Comprehensive Nanoparticle Analysis
Xiamen, China & Nottingam, UK
Joined April 2020
NanoFCM analyzes LNPs at single-particle level: Quantifies payload-carrying particles Links size to encapsulation Profiles ligand density Resolve heterogeneity in minutes. Go beyond averages. #LNP #mRNA #DrugDelivery #NanoFCM
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Go beyond bulk EE%. Use single-particle analysis (nano flow) to see the exact % of empty LNPs and mRNA copies per particle. Essential for precise LNP formulation. #DrugDelivery #mRNA
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Dive into the next-gen therapy big pharma is chasing: in vivo CAR-T. Explore the disruptive reprogramming approach & how to consolidate analytics to accelerate R&D in our live webinar. 🗓️ Live: Oct 2 - 8:00 PT, 11:00 ET, 17:00 CET Register 👉 https://t.co/iNVhqpkgoZ
#CARTcell
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🔬 Low Ag on virions → faint signal. 📊 HIV-CD38: 74-170 PE-MESF. Events often negative. ✅ Signal > background = positive. 🧬 Boost S/N: MESF cal, controls, bright fluors, clean buffers, strict gating. ⚠️ MESF ≠ copies. #FlowVirometry #Virology
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🔬 Functional titers (plaque/TCID₅₀) measure infectivity - regulatory gold standard! 🔬 Flow Virometry = rapid particle count but can't detect infectivity directly ✨ New FPT proxy tracks infectivity in <1h! Great for QC when time is critical #FlowVirometry #ViralTiter #Biotech
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Fluorometric flow cytometry reveals real-time viral shape-shifting—quantifying individual virions (27-100nm) with stats, unlike bulk assays. Game-changer for vaccine QC & pathogenesis! #FlowVirometry #Virology
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#NanoFCM distinguishes viruses from extracellular vesicles using nucleic acid staining. Genome+ virions are separated from EVs, enabling precise quantification and purification. Essential for clean viral and EV preps. #VirusPurification #FlowVirometry
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Flow virometry detects & analyzes viruses (27–100 nm) via light scatter & fluorescence. Calibrated with beads (e.g., QuantiBRITE, Rosetta), it quantifies particle size, concentration, & antigen density (PE MESF/nm²). Proven for HIV-1 & MLV studies. #FlowCytometry #ViralDetection
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🚀 CAR-T Therapy evolves fast! Join Joseph Brealey of NanoFCM to discover game-changing in vivo CAR reprogramming & consolidated analytics for efficient R&D. 🗓️ LIVE: July 24 - 8:00 PT/11:00 ET/17:00 CEST 🔗 Register:
DON'T MISS OUT! On 7/24, Joseph Brealey, an expert in nanoparticle delivery, will discuss current strategies for improving quality control of in vivo CAR T therapies. Register now to join us for this free webinar sponsored by @nano_fcm: https://t.co/FLri0qKr8T
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🔬 Yes! 10nm LNP size shifts (e.g., 40-80nm vs larger) impact drug delivery potency, biodistribution & cellular uptake. Precision sizing now possible via microfluidics. #Nanomedicine #LNP #WhitePaper 👉 Details: https://t.co/vxouy94Jol
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🚀 CAR-T Therapy New Era In vivo engineering: faster, safer cancer treatment. 🔬 Join NanoFCM's expert Joseph Brealey's webinar on nanoparticle analysis for CAR therapy QC & development. 👉 Register: https://t.co/iNVhqpkOex
#CART #immunotherapy #genetherapy #LNP
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EMA tightens mRNA-LNP vaccine QC rules: • Particle size • Encapsulation rate • mRNA integrity • Empty LNPs Our integrated CQA testing streamlines compliance - faster, cheaper QC for scalable production. Need analytical solutions? Let's talk. #mRNA #VaccineQC #LNPs
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Optimizing nanoscale drug delivery? NanoFCM's analytical workflows help characterize LNPs: ✅ Size/concentration ✅ Empty/full ratio ✅ mRNA copy number ✅ Encapsulation efficiency ✅ Ligand incorporation Hit roadblocks? Let's solve your #LNP challenges together! #DrugDelivery
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No #EV gold standard? Optical methods (NTA/DLS/SSC) need assumptions → fail with: • Low-RI EVs • Polydisperse samples • RI heterogeneity Solution: RI-matched beads + Mie theory + SSC calibration ≈ TEM accuracy + speed! #ExtracellularVesicles #NanoFCM
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Thrilled for #APSEV2025 by #SOCRATES! Collab w/ EV societies across APAC. Join our session to decode EV analytics & master precision measurement strategies. #ExtracellularVesicles #EVs #EVAnalytics #FlowCytometry #NanoFCM
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Exciting advance in CAR therapy! Myeloid Therapeutics pioneers in vivo mRNA-LNP CARs targeting solid tumors. NanoFCM 's single-molecule analyzer enables precise mRNA/surface ligand quantification, streamlining workflows. DM to explore! #CARTcelltherapy #mRNALNP #Immunotherapy
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Capstan's LNP tech delivers CAR mRNA to blood T cells in vivo, skipping ex vivo steps. Challenges: protein corona & T cell uptake barriers. Benefits: faster/cheaper, wider cancer applicability, transient CAR expression. #CARTcell #LNPs #mRNAtherapy
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In vivo CAR-T uses LNPs to reprogram T cells inside the body (vs. traditional 3-4 week ex vivo process). Key challenge: Targeting LNPs to immune cells via antibodies, ligands, or peptides. #CARTcell #Immunotherapy
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Off-the-shelf CAR-T skips leukapheresis & custom manufacturing, delivering QC-approved batches in days vs weeks. Game-changing speed for life-saving treatments! How are you optimizing nanoparticle delivery for CAR reprogramming? #CART #CellTherapy #Biotech
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