#NAPLEX #pharmacy #medicine #statins

💊NAPLEX MedFact. Fluoroquinolones can worsen symptoms of myasthenia gravis by interfering with neuromuscular transmission. ☑️They exert a direct neuromuscular-blocking effect at the acetylcholine receptor or presynaptic terminal, leading to increased muscle weakness or even

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💊NAPLEX MedFact. Nifedipine is a calcium channel blocker (dihydropyridine type) used primarily for cardiovascular and obstetric indications. ☑️Its main uses include the management of hypertension (both chronic and hypertensive emergencies such as hypertensive urgency) and

💊NAPLEX MedFact. Key differences between unfractionated heparin and LMWHs you need to know: 1⃣Molecular Weight 🔸UFH: large (~15,000 Da) 🔸LMWH: smaller (~4,000–6,000 Da) 2⃣Mechanism of Action 🔸UFH: inhibits both Factor Xa and Thrombin (IIa) equally via antithrombin

💊NAPLEX MedFact. Gabapentin works primarily by binding to the α2δ (alpha-2-delta) subunit of voltage-gated calcium channels in the CNS. ☑️This binding reduces calcium influx into neurons during depolarization, thereby decreasing the release of excitatory neurotransmitters such

💊NAPLEX MedFact. Tocilizumab is a humanized monoclonal antibody that targets the IL-6 receptor, thereby inhibiting IL-6–mediated signaling involved in inflammation and immune activation. ☑️It is primarily indicated for the treatment of moderate to severe rheumatoid arthritis,

💊NAPLEX MedFact. Several drugs are known to cause hypomagnesemia, usually by increasing renal excretion, reducing intestinal absorption, or causing shifts into cells. The most common drug-induced causes are: 1⃣Diuretics 🔸loop diuretics (e.g. furosemide, bumetanide,

💊NAPLEX MedFact. Iron salts, such as ferrous sulfate or ferrous fumarate, can interact with several substances that affect their absorption or cause adverse effects. ☑️They commonly interact with antacids, proton pump inhibitors, and H2 blockers, which reduce stomach acidity

💊NAPLEX MedFact. Sunitinib is an oral multi-targeted tyrosine kinase inhibitor used primarily to treat renal cell carcinoma, gastrointestinal stromal tumors (GIST) after imatinib failure, and pancreatic neuroendocrine tumors. ☑️It works by inhibiting multiple receptor

Twice-weekly intravenous (IV) ketamine over a 4- to 5-week induction period for severe treatment-resistant depression (TRD) was associated with a faster and greater reduction in symptoms than intranasal (IN) esketamine, although overall tolerability was similar, a new

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💊NAPLEX MedFact. Among the fluoroquinolones, levofloxacin, moxifloxacin, and gemifloxacin exhibit enhanced activity against gram-positive organisms, particularly Streptococcus pneumoniae, compared to earlier agents such as ciprofloxacin and ofloxacin. ☑️These drugs are often

💊NAPLEX MedFact. Thiazolidinediones (TZDs) and fibrates are both drug classes that exert their effects by activating peroxisome proliferator-activated receptors (PPARs), a group of nuclear receptors that regulate gene expression involved in metabolism. ☑️While TZDs primarily

💊NAPLEX MedFact. Tardive dyskinesia (TD) is considered a late-onset side effect because it typically develops after long-term or prolonged use of certain drugs, especially antipsychotic drugs that block dopamine receptors in the brain. ☑️Unlike acute movement disorders that

FDA Approves Rhapsido (remibrutinib) for the Treatment of Chronic Spontaneous Urticaria

💊NAPLEX MedFact. Pegvisomant is a genetically engineered growth hormone receptor antagonist used to treat acromegaly, a condition caused by excessive growth hormone (GH) production. ☑️It works by blocking GH receptors, thereby reducing the production of insulin-like growth

💊NAPLEX MedFact. What are the key differences between zopiclone and eszopiclone? ☑️Zopiclone and eszopiclone are both non-benzodiazepine hypnotics (“Z-drugs”) used to treat insomnia, but they differ slightly in pharmacology and clinical profile. ☑️Zopiclone is a racemic

💊NAPLEX MedFact. Digoxin toxicity is known to cause visual disturbances, most notably xanthopsia, or yellow-tinted vision. ☑️This occurs because digoxin interferes with the function of retinal photoreceptors and the visual processing pathways in the brain. ☑️Patients may

💊NAPLEX MedFact. Why does the antiplatelet effect of aspirin occur at low doses? 1⃣Aspirin irreversibly inhibits the enzyme COX-1 in platelets, which is responsible for converting arachidonic acid into thromboxane A₂ (TXA₂), a molecule that promotes platelet aggregation and

💊NAPLEX MedFact. Top 7 risk factors for vancomycin infusion syndrome, previously known as 'red man syndrome': 1⃣Infusion Rate Rapid infusion of vancomycin (>10 mg/min) is the most significant risk factor. Faster rates increase histamine release, leading to flushing,

💊NAPLEX MedFact. Thalidomide is a drug used in the treatment of multiple myeloma. ☑️Approved in 2006 by the FDA for relapsed or refractory multiple myeloma, thalidomide is often combined with dexamethasone to enhance response rates. ☑️Despite its benefits, its use is limited