Skeletal Mechanobiology & Biomechanics Lab
@MorganLabBU
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We've transitioned to Bluesky! For the latest updates, follow our new account at @morganlabbu.bsky.social
Boston, MA
Joined November 2018
RT @edguo84: @EliseFMorganPhD gave an outstanding keynote at @ORSsociety Asian Leadership Forum Network Breakfast fast. It is greatly appr….
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(4/4) And our newest post-doc, Mengyao, will be presenting findings from her previous work entitled “PRMT5 Deficiency Under Low Se Status Exuberates Cartilage ECM Degradation” at Poster #2331 from 6:15 - 7 PM.
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(3/4) Next up, @NeilFrings will be presenting his work on the “Biomechanical, Structural, and Composition Characterization of the Vertebra-disc Interface” at Poster #1591 from 6:15 - 7 PM.
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(2/4) Our post-doc, Shengzhi, will be presenting his work titled “A Data-driven Framework for Modulus-density Relationship of Human Lumbar Vertebral Body” at Poster #1680 from 5:30 - 6:15 PM.
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(1/4) Want to connect with our lab on Monday at #ORS2025? You can find our lab at Poster Session 2! Check out the info below 👇 for topics being presented:.
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RT @BrianneConnizzo: If you're an undergraduate interested in a orthopaedics-based summer research opportunity in Boston, apply today for t….
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The SMBL is excited to attend #ORS2025 starting next FRIDAY!! 🙌 Be sure to catch @EliseFMorganPhD speaking at the Bone Quality in Osteoporosis session (5:00 PM), about the vertebral bony endplate’s role in osteoporosis!.
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Happy Halloween from the SMBL!🎃It's bound tibia good one. - love, the SMBL skeleton
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(5/5) How do these designs perform in vitro and in vivo, and how can we use this optimization approach to better understand skeletal cell mechanobiology? Stay tuned!.
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(4/5) We show that our microenvironment-focused mixed-topology optimization approach generates enhanced scaffold designs using literature-based scoring functions while also controlling for other scaffold properties, like apparent modulus.
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(3/5) Our low-parameter topology-varying optimization approach, “mixed-topology” optimization, can continuously morph between a set of initial scaffold architectures, generating unique designs with microenvironments and mechanical behavior distinct from the original structures.
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(2/5) We focus on local, microenvironmental mechanical stimuli that arise from macroscale compression and perfusion, in addition to local surface curvature, that influence cell behavior and can either promote or inhibit osteogenesis.
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(1/5) How can cues from the microenvironment inform scaffold design for bone tissue engineering? Check out our new paper “Mechanobiological optimization of scaffolds for bone tissue engineering” in Biomechanics and Modeling in Mechanobiology @TimOJosephson
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RT @BUmechanobio: Next up: @TimOJosephson from the @MorganLabBU presenting his work in tissue engineering meshing software development! #m….
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Congratulations, Chelsea!.
Our next steps will be supported by the #nsfcareer!!! YAY! We will use novel imaging and metabolomics tools to investigate osteocyte interactions with bone matrix and impacts on fracture toughness. We will also introduce nontraditional MSU students to research! Can't wait.
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Magnificent example of biological feedback control.
Very excited to share our new preprint where we use a deep learning-based feedback algorithm to control gene expression in real time in thousands of single E. coli cells in parallel. This work was led by @jblugagne and @cblassick. 1/
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RT @DunlopLab: Very excited to share our new preprint where we use a deep learning-based feedback algorithm to control gene expression in r….
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RT @meghankup: Cool new work from @MorganLabBU and @ElliottLab shows that IVD geometry has a strong influence on the mechanical responses p….
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