Moldovan Lab
@MoldovanLab
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Genome stability, DNA repair, replication stress, functional genomics, basic cancer biology
Hershey, PA
Joined December 2020
So happy and proud to hood Drs. Lindsey Pale, Jude Khatib and Josh Straka at the 2025 Penn State College of Medicine Commencement ceremony. Congratulations and all the best in your careers!
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Happy to share our new collaboration paper in Cell Reports. We show that translation synthesis in cancer cells occurs predominantly behind the replication fork, to fill ssDNA gaps, rather than to restart stalled replication forks “on the fly”.
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Congratulations Dr. Straka! Josh successfully defended his PhD thesis today. Wishing him all the best in his future career!
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Happy to share our new publications in Nucleic Acids Research on the regulation of PRIMPOL
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Check out our review on the impact of bisphenol A (BPA) on genomic stability
academic.oup.com
Abstract. Bisphenol A (BPA) is a phenolic chemical that has been used for over 50 years in the manufacturing of polycarbonate and polyvinyl chloride plasti
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Congratulations Dr. Khatib! @JudeBKhatib successfully defended her PhD thesis today. Looking forward to her future accomplishments!
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PS. Ashna is not yet done with genome stability: look out for her final paper from the lab coming out (hopefully) soon!.
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Bittersweet day, saying goodbye to Dr. Ashna Dhoonmoon who leaves the lab today after 5+ tremendous years with us. She was the heart and soul of the lab and we will miss her dearly. @Ashna_Dh All the best in your future career!
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Grateful for the opportunity to present our work this week, and happy to see three other former graduate students of the late Stefan Jentsch on this list @PfanderLab @RapeLab @stingele_lab. This one is for you, Stefan!.
Where is the spring? Are you ready for the summer? Social DNAing is. Check out our 2024 late spring and summer speakers. The website will be updated soon: Thank you for helping us RT.
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The final lab selfie with @Lindsey_Pale as member of our group. Wishing her all the best as she transitions into the next phase of her career.
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We attended our Departmental Annual Retreat. @anastasiamhale and @Ashna_Dh gave oral presentations and @JudeBKhatib won the best poster award. Congrats everyone! Stay tuned for their new stories coming out soon!
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Happy to share our new manuscript @Lindsey_Pale.
CRISPR knockout genome-wide screens identify the HELQ-RAD52 axis in regulating the repair of cisplatin-induced single stranded DNA gaps #biorxiv_cancer.
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RT @Lindsey_Pale: What a great week at the GRS/GRC on DNA Damage, Mutation and Cancer in beautiful sunny Ventura CA! @ShrabastiRoych1 and I….
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Happy to share our publication in NAR at the beginning of the new year: USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during replication stress
academic.oup.com
Abstract. DNA replication stress-induced fork arrest represents a significant threat to genomic integrity. One major mechanism of replication restart invol
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