Michael Kelberman
@MikeKelberman
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Donaldson Lab Post Doc at CU Boulder | Locus Coeruleus Enthusiast | SaintsFC
Joined June 2019
RT @NSS_PIA: Dear NSS speakers in AAIC25, please add the QR codes for the future PIA members. @ajehrenberg @NeusFalgas @ElouiseKoops @MikeK….
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RT @HeidiJacobsLab: Deadline extended till April 14! Do you love the locus coeruleus, hypothalamus, raphe nucleus, basal forebrain,… ? Join….
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RT @NinaEngels: Join us at the Integrative Neuromodulatory Subcortical Systems 2025 meeting! Supported by @ISTAART and hosted by @NSS_PIA &….
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RT @NSS_PIA: @ISTAART @NSS_PIA Year in Review is next week! .Friday, Jan-24, 10am CT (USA).Speakers: @marionbaillet @neurosciencenic .Moder….
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RT @NelsonTotah: I am delighted to share our new paper: "Diversity of ancestral brainstem noradrenergic neurons across species and multiple….
biorxiv.org
The brainstem region, locus coeruleus (LC), has been remarkably conserved across vertebrates. Evolution has woven the LC into wide-ranging neural circuits that influence functions as broad as...
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Thank you to @NelsonTotah for conceptualizing and leading this study, as well as @LCneuroscience and @ProbablyLC for their input throughout, and to all the co-authors who contributed data. We hope this will be a good resource for everyone performing LC ephys recordings!.
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Additionally, co-first author @Science_Ellen used interspike intervals to characterize firing patters of LC neurons, showing greater diversity in firing pattern than the previous tonic/phasic definitions, which also depended on experimental factors.
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We found that LC firing rates vary across species, state of the animal, sex, and age, in addition to complex interactions between these factors. Highlights include increasing LC activity during aging and in females compared to males.
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Attention all LC lovers, this is a pre-print you won't want to skip! We combined over 1800 single unit LC recordings across 20 labs to ask whether LC firing is different across various conditions
biorxiv.org
The brainstem region, locus coeruleus (LC), has been remarkably conserved across vertebrates. Evolution has woven the LC into wide-ranging neural circuits that influence functions as broad as...
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This work is related to the recently published work from @BohacekLab and @Valerio_Zerbi
nature.com
Nature Neuroscience - Tonic and burst-like locus coeruleus firing distinctly tune brain topology toward associative and sensory regions, recruiting both astrocytic and neuronal inhibitory activity.
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Work from my PhD looking at how LC optogenetic stimulation affects global brain dynamics with fMRI has been published in @ImagingNeurosci!
direct.mit.edu
Abstract. Whole-brain intrinsic activity as detected by resting-state fMRI can be summarized by three primary spatiotemporal patterns. These patterns have been shown to change with different brain...
Another day another pre-print, this time for the LC enthusiasts! This is part of the final pieces of my graduate work with @LCneuroscience where we wanted to know how different rates/patterns of LC stimulation impact global spatiotemporal brain patterns
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My first experiments as a post-doc are finally published in @HormBehav! Aged voles have a lot of love to give, demonstrating accelerated and enhanced pair bonding which is paralleled by an increase in oxytocin cell counts of the PVN.
Excited to share the first pre-print of my post-doc with @DrZoePhD. At the end of my PhD, I became interested in how social behaviors evolve during aging, particularly in late stages of life. But mice/rats do not display many of the complex social behaviors as observed in humans.
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Miss my talk at PIA day or just really interested in learning more about voles? For all the locus coeruleus enthusiasts, stop by my poster at #AAIC24 on Tuesday to learn about pair bonding and norepinephrine in the context of Alzheimer's disease!
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Make sure not to miss any of these fantastic talks, including some of my new work looking at changes in oxytocin and vasopressin systems over the course of aging in prairie voles!.
Don't miss PIAday tomorrow! The mighty @NSS_PIA will be sharing special announcements, revealing the publication award and we will be discussing exciting new findings from several researchers at 11:00AM! @ISTAART #AAIC24
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RT @HeidiJacobsLab: Don't miss PIAday tomorrow! The mighty @NSS_PIA will be sharing special announcements, revealing the publication award….
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