MR_lit
@Mendelian_lit
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Manuscript alert for genetic studies using Mendelian Randomisation. Sources: Pubmed, Biorxiv & Arxiv By @wpgilks Also see @gwas_lit and @genomic_pred
Sussex, England
Joined November 2016
Causal Associations of Circulating Helicobacter pylori Antibodies with 5 Skin Disorders: A Mendelian Randomization Analysis
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MR Corge: Sensitivity analysis of Mendelian randomization based on the core gene hypothesis for polygenic exposures
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Interpretation of two-sample Mendelian randomization for binary exposures and outcome
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Deciphering the Influence of Socioeconomic Status on Brain Structure: Insights from Mendelian Randomization
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Genetics-driven Risk Predictions with Differentiable Mendelian Randomization
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Causal mediation analysis for time-varying heritable risk factors with Mendelian Randomization
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Causal associations between gut microbiota and regional cortical structure: a Mendelian randomization study
pubmed.ncbi.nlm.nih.gov
Specific gut microbiota may causally influence cortical structure in brain regions involved in neuropsychiatric disorders. The findings provide evidence for a gut-brain axis influencing cortical...
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Relationship between alcohol consumption and dementia with Mendelian randomization approaches among older adults in the United States
pubmed.ncbi.nlm.nih.gov
Alcohol consumption was not associated with cognitively impaired, non-dementia or dementia status.
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Genetically predicted circulating concentrations of micronutrients and risk of hypertensive disorders of pregnancy: a Mendelian randomization study
pubmed.ncbi.nlm.nih.gov
There is no strong evidence to support the causation between circulating micronutrients and hypertensive disorder during pregnancy.
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Periodontitis and thyroid function: A bidirectional Mendelian randomization study
pubmed.ncbi.nlm.nih.gov
This bidirectional MR reveals periodontitis should not be attributed to variations in thyroid function but it has potential causal effect on hypothyroidism risk, which provides a better understanding...
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Causal effects and immune cell mediators between prescription analgesic use and risk of infectious diseases: a Mendelian randomization study
pubmed.ncbi.nlm.nih.gov
This MR study provides new genetic evidence for the causal relationship between PAU and ROI, and the mediating role of immune cells was demonstrated.
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Specific gut microbiota may increase the risk of erectile dysfunction: a two-sample Mendelian randomization study
pubmed.ncbi.nlm.nih.gov
Six gut microbes were genetically associated with ED; of which, Ruminococcaceae UCG-013 was causally associated with a reduced risk of ED development. Our findings provide a new direction for...
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Iron and risk of dementia: Mendelian randomisation analysis in UK Biobank
pubmed.ncbi.nlm.nih.gov
Genetic evidence supports a causal relationship between higher TSAT and risk of clinically defined non-AD and vascular dementia, in European and African groups. This association appears to be...
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Associations of fatty acids with the risk of biliary tract calculus and inflammation: a Mendelian randomization study
pubmed.ncbi.nlm.nih.gov
These Mendelian randomization findings suggested that more attention should be focused on people who have low serum PUFA levels, which may have a potential role in the occurrence of calculus of the...
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Causal Association Between Sepsis and Neurodegenerative Diseases: A Bidirectional Two-Sample Mendelian Randomization Study
pubmed.ncbi.nlm.nih.gov
The present study contributes to a deeper comprehension of the intricate interplay between sepsis and neurodegenerative disorders, thereby offering potential avenues for the development of therapeu...
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Increased muscle mass increases risks of intervertebral disc degeneration: a two-sample Mendelian randomization study
pubmed.ncbi.nlm.nih.gov
Increased muscle mass may increase the risk of intervertebral disc degeneration.
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Assessment of causal association between differentiated thyroid cancer and disordered serum lipid profile: a Mendelian randomization study
pubmed.ncbi.nlm.nih.gov
We obtained four exposure factors (total cholesterol, HDL cholesterol, apolipoprotein B and ratio of apolipoprotein B to apolipoprotein A1) closely related to DTC, which laid a theoretical foundation...
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Causal association of immune cells and polycystic ovarian syndrome: a Mendelian randomization study
pubmed.ncbi.nlm.nih.gov
Our MR analysis provides strong evidence supporting a causal association between immune cells and the susceptibility of PCOS. This discovery can assist in clinical decision-making regarding disease...
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Tumor necrosis factor mediates the impact of PM2.5 on bone mineral density: Inflammatory proteome Mendelian randomization and colocalization analyses
pubmed.ncbi.nlm.nih.gov
To assess the causal effect of particulate matter 2.5 (PM2.5) on human bone mineral density (BMD) and to explore the possible mechanism and proportion mediated by inflammation-related protein. The...
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Mendelian randomization identifies circulating proteins as biomarkers for age at menarche and age at natural menopause
pubmed.ncbi.nlm.nih.gov
Age at menarche (AAM) and age at natural menopause (ANM) are highly heritable traits and have been linked to various health outcomes. We aimed to identify circulating proteins associated with altered...
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