Mehershad Wadia
@MehershadW
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Neuroscientist, Writer, Comedian(?) 🔬@HilliardLab
Brisbane
Joined March 2021
RT @marmol_dr: It's a honour to announce that I'm the recipient of the 2025 I.Peter Farrell SpinalCure Fellowship. Thanks to the generosity….
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I'll be MCing the wonderful @pintofscienceAU festival featuring some outstanding scientists!. 📍 Easy Times Brewing Co.🗓️ 19th to 21st May!. Come along for an evening full of wonderful science brewing right here in Brisbane!. @UQ_News @CSIRO
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RT @breast_lab: Exciting news – @amymccart is speaking at @pintofscienceAU! 🎤👏. 🗓️ Tues 20 May.📍 Easy Times Brewing Co, Brisbane.🧬 Cuts, Cu….
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RT @HilliardLab: Do not miss out on this amazing meeting! The deadline for abstract submission and registration is March 1st. Check out th….
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RT @EMBO: Open call! The EMBO Global Investigator Network supports group young leaders who are setting up their laboratories in Chile, Indi….
embo.org
Supporting young group leaders in Chile, India, Singapore and Taiwan
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RT @QldBrainInst: Congratulations to the @HilliardLab at QBI whose paper titled "OSP-1 protects neurons from autophagic cell death induced….
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RT @HilliardLab: Out now! We found a new molecule, OSP-1, that protects neurons from damage caused by oxidative stress. We show that OSP-1….
nature.com
Nature Communications - How oxidative stress impacts neurons is poorly understood. Here the authors reveal that overactivation of autophagy following oxidative stress contributes to neuronal death...
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Our paper is now featured in the @NatureComms Editors' highlights! 🙌 .
nature.com
This page highlights recent articles advancing our knowledge in molecular, cell and developmental biology, including disciplines as diverse as cell division, ...
NEW Paper:.If you're a fan of Rachel from 'Friends', you would love OSP-1, as it is also protective of ROS. Donato et al. found a novel gene OSP-1 (oxidative stress protective 1) that protects neurons from damage caused by reactive oxygen species (ROS), by modulating autophagy.👇
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RT @HilliardLab: Congratulations, Ramon, on this outstanding achievement! We're very excited by the groundbreaking discoveries that lie ah….
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👏👏👏.
Congratulations to our PhD student, Lachlan Lu, for winning the Best Presentation award for his talk at the @QldBrainInst CJCADR seminar series!
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OSP-1 could potentially become a target for future treatments protecting neurons from oxidative insults and these findings could help treat conditions such as stroke. Massive congratulations again to Alessandra, Massimo and fellow authors for their amazing and inspiring work🔬🙌.
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As the ER interacts with lysosomes, we show that OSP-1 mutants have altered lysosome clustering within neurons, which is known to affect autophagy. We show that autophagy inhibition conferred similar protection & propose that OSP-1 functions as a negative regulator of autophagy.
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To understand how exactly OSP-1 protects C. elegans neurons, we tried to visualise where the molecule functions. We found that OSP-1 localised to the ER membrane and caused rearrangement of the ER. (Mutated OSP-1 reduced ER branching in the proximal axonal segment)👇
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Neurons were on a 'break':.Using targeted ROS generation, we saw that C. elegans worms with a mutated OSP-1 (vd60) had higher neuronal damage & reduced lifespan. Interestingly, providing OSP-1 to rodent & human cultures protected these mammalian cells against oxidative insults!
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NEW Paper:.If you're a fan of Rachel from 'Friends', you would love OSP-1, as it is also protective of ROS. Donato et al. found a novel gene OSP-1 (oxidative stress protective 1) that protects neurons from damage caused by reactive oxygen species (ROS), by modulating autophagy.👇
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RT @QldBrainInst: Researchers from the Hilliard lab at UQ's Queensland Brain Institute have identified a molecule, OSP-1, that may protect….
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