M. Selvaraj
@M__Selvaraj
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Studying plant, pathogen proteins, their structures with X-rays and electrons.
Germany
Joined May 2012
RT @KamounLab: First a pentamer, then a hexamer… now an octamer! . The riddle of the enigmatic CCG10-NLR immune receptor family cracked ope….
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Please read here about a plant disease resistance protein that makes an octameric resistosome. We describe about its identification, architecture, action and assembly. Congrats to all involved. @GuanghaoGuo, He Zhao @mhz1989 .@jonathandgjones @KamounLab @TheSainsburyLab 👇.
New preprint! We report the largest plant resistosome ever described. We revealed the wheat NLR WAI3, a member from the mysterious CCG10-NLR clade, forms an unprecedented octameric assembly with a unique channel architecture. And the well-known RPS2 might work the same way!
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RT @mhz1989: Wheat never fails to surprise us—like a CNL that assembles just like a TNL!
biorxiv.org
Nucleotide-binding and leucine-rich repeat (LRR) receptors (NLRs) are widespread intracellular immune sensors across kingdoms. In plants, the G10-type coiled-coil (CCG10)-NLRs form a distinct...
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RT @awkwardgoogle: This brave guy in Florida came up with a pretty clever way to deal with an alligator!.
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RT @KamounLab: I just published 2024 the year in review . Let’s review the year through our team’s publications, blogs and other contributi….
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A trade-off between investment in molecular defense repertoires and growth in plants | Science
science.org
Given the negative fitness effects that pathogens impose on their hosts, the benefits of resistance should be universal. However, there is marked variation across plant species in the number of...
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RT @biorxiv_plants: Structure determinants of DANGEROUS MIX 3, an alpha/beta hydrolase, for triggering NLR-mediated genetic incompatibility….
biorxiv.org
Genetic incompatibility occurs when a mismatched pair of plant immune components mounts autoimmune responses in hybrids. Highly diversified NLR receptors are main culprits of the genetic conflict,...
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RT @PLOSBiology: #Plants use NLRs for #pathogen defense, but what do downstream "helper" #NLRs do? @M__Selvaraj @mpcontreras4 @KamounLab &c….
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Reliable reconstruction of cricket song from biophysical models and preserved specimens
biorxiv.org
Predicting the function of a biological structure solely from its morphology can be a very powerful tool in several fields of biology, but especially in evolutionary reconstruction. In the field of...
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A versatile protocol for purifying recombinant proteins from Nicotiana benthamiana for structural studies
biorxiv.org
Structural biology is an essential tool for understanding the molecular basis of biological processes. Although predicting protein structures by fold recognition algorithms has become increasingly...
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RT @DrSuriya_: சரியான முடிவுகள் எடுப்பதில் எனக்கு நம்பிக்கை இல்லை. நான் முடிவுகளை எடுத்த பின் அதை சரியாக்குவேன் - Ratan TATA. Rip sir. 😭😭….
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RT @TarhanEI: 🚨 A new twist in #NLRbiology! 🚨. Excited to report on the surprising mechanism where the helper NLR NRG1 targets organellar m….
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On the response of elongating ribosomes to forces opposing translocation: Biophysical Journal
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A two-component signature determines which rust fungi secreted proteins are translocated into the cells of the host plant
biorxiv.org
Rust diseases of plants are caused by parasitic fungi that feed off living plant cells by means of haustoria that form within plant cells. These haustoria also secrete a large number of proteins,...
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A sharp discovery | Science
science.org
Plant prickles are controlled by genes involved in the final step of cytokinin biosynthesis
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RT @dianagdlc: I am *beyond thrilled* to have the work from my PhD finally out!! 💫.We found that MLA3, a plant immune receptor, mimics a vi….
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RT @mpcontreras4: Beautiful thread on how AlphaFold3 can be used to confidently model CC-NLR resistosomes! Turns out oleic acids can be use….
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