Dr Luned Badder
@LunedBadder
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Cancer Research Scientist working with virotherapies and organoids 👩🔬🔬🏴 Gwyddonydd ymchwil yn arbenigo mewn organoidau a feirysau oncolytig
Cardiff, Wales
Joined July 2009
📣Thrilled to share that our paper describing a smart virus capable of delivering "in tumour chemotherapy" for pancreatic cancer is now published online 🎉 Read all about it here: https://t.co/4RMXd6xC32
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Calling all UK-based #PancreaticCancer researchers! 🔬 We’re conducting a census to find out what resources & expertise exist within the pancreatic cancer research community. Take part to help us direct investments in community infrastructure & support: https://t.co/YSTfU2At8Q
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It’s time for the next set of our #FellowshipFriday celebrations! Today we are celebrating those who have received their Associate Fellow, Fellow, and Senior Fellowships this term. 👏👏🌟🌟 #CUFellowships
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Some fascinating insight into using #viruses to deliver “in-tumor” chemotherapy in #PDAC, led by Drs. @LunedBadder, @alanlparker, and their @cardiffuni team! 🔗: https://t.co/ThGkuCE5tD 🧵: Read about their findings in @LunedBadder's thread:
nature.com
British Journal of Cancer - The αvβ6 integrin specific virotherapy, Ad5NULL-A20.FCU1, selectively delivers potent “in-tumour” chemotherapy to pancreatic ductal adenocarcinoma
📣Thrilled to share that our paper describing a smart virus capable of delivering "in tumour chemotherapy" for pancreatic cancer is now published online 🎉 Read all about it here: https://t.co/4RMXd6xC32
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Tu hwnt o ddiolchgar i i bawb a gyfrannodd i’r gwaith yma. Ymlaen i brofi’r dechnoleg yma ymhellach!
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Er bod ein gwaith wedi canolbwyntio ar brofi ein feirws clyfar ar gelloedd ac organoidau wedi eu tyfu o fiopsïau cleifion canser y pancreas, rydym yn obeithiol y bydd y dechnoleg yma yn berthnasol i nifer o fathau eraill o ganser
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Rydym yn gobeithio bydd y dull yma yn gallu cynnig opsiwn o ddarparu cemotherapi yn uniongyrchol o fewn celloedd tiwmor, i gyfyngu ar y sgil-effeithiau gwenwynig cemotherapi ar weddill y corff, gan arwain at driniaethau mwy effeithiol ac addawol ar gyfer canser y pancreas.
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Rydym wedi addasu feirws clyfar yn bellach fyth i gludo cod genetig i gelloedd canser sydd yn eu gorfodi i gynhyrchu cyffur cemotherapi yn y pen draw, sydd yn cael ei ryddhau yn lleol a'u lladd.
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Mae'r gwaith yma yn seiliedig ar ddatbylgu 'feirysau clyfar' wedi eu haddasu yn y labordy i heintio celloedd canser yn unig heb niweidio celloedd iach y corff, ar gyfer trin canser y pancreas yn ddiogel ac yn effeithiol.
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📣Hynod falch i weld fod ein gwaith wedi ei gyhoeddi ac ar gael ar-lein rwan🎉 https://t.co/4RMXd6xC32
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Beyond grateful to be a member of such a wonderful team of scientists @virustinkerer and a special thanks to all those that contributed. Not forgetting our funders for supporting this work
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Whilst our work has focused on the application of our precision virotherapy in #pdac, we believe this could be applicable to numerous other αvβ6 integrin+ cancer types too, and provide a promising candidate for clinical applications, offering hope for improved patient outcomes.
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This approach shows promise to achieve chemotherapeutic delivery locally within tumour cells, and has the potential to limit the systemic toxic side effects we normally associate with current chemotherapy regimens, ultimately leading to smarter and kinder treatments for #pdac
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Using in vitro cell lines and clinically-relevant 3D organoid models, we show selective transduction of our precision virotherapy, as well as a potent therapeutic effect when given in combination with 5-FC.
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Targeted delivery of such suicide genes enable the expression of enzymes capable of converting 5-FC, a non-toxic anti fungal, to 5-FU, a commonly used chemotherapeutic drug, directly within cancer cells.
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We describe the generation of a precision virotherapy that can selectively infect and deliver "suicide genes" to Pancreatic ductal adenocarcinoma via αvβ6 integrin, a tumour-selective marker.
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Viruses can be smart things, and here we show you can use #viruses to force #tumour cells to make their own #chemotherapy…just out in @BrJCancer
https://t.co/5IiRCT7bop Precision VDEPT/“in-tumour” chemotherapy for #pancreatic #cancer Congrats 🥳 first author @LunedBadder
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The @virustinkerer lab are celebrating #StripeAPose day for our fabulous funders @cancer_wales 👊👏👏 🧬🧫🥼🧪
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Roedd Dr Bryn Hughes Parry yn siarad am Darganfod ac Ysbrydoli: Darlithoedd a Sgyrsiau Gwyddoniaeth a Thechnoleg - Eisteddfod Llŷn ac Eifionydd 2023 ar Dros Frecwast @BBCRadioCymru Gwrandewch eto, tua 35 munud i mewn i'r rhaglen: https://t.co/E7r0Tgotol
@LlyfrauCymru
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Er yn boblogaidd yn y byd cyhoeddi Saesneg, mae cyfrolau am wyddoniaeth a thechnoleg gyffredinol yn brin iawn yn y Gymraeg. Darllenwch mwy>> https://t.co/LCw5a5hXG4 Mae Darganfod ac Ysbrydoli ar gael nawr, £9.99 @LlyfrauCymru #yagym
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