Luigi Lorenzini
@LuigiLorenzini1
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Joined August 2020
Big thank to all coauthors, among them Alessio Maranzano, @silvia_ingala , @FBarkhof , @LECollij , @MarioTranfa , @JuandoGispert , @MichaelEwers12.
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We further used structural equation models to investigate the dependent and independent contributions of these factors on subsequent pathological events (tau, atrophy, and cognitive deterioration)
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The most fun image & video creation tool in the world is here. Try it for free in the Grok App.
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We used latent factor analysis on cSVD MRI radiological markers, and showed that cSVD-burden mediates the association between systemic vascular factors and initial amlyloid deposition
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Happy to see this out after long time and effort we put into it! .Important collaborative work where we examined the interrelationship between systemic vascular factors, cerebrovascular disease and AD pathological changes in non-demented individuals .
neurology.org
Background and ObjectivesVascular risk factors (VRFs) and cerebral small vessel disease (cSVD) are common in patients with Alzheimer disease (AD). It remains unclear whether this coexistence reflects...
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RT @IMI_AMYPAD: Amazing week so far at #AAIC24 with inspiring talks & engaging discussions🌟. Yesterday, @LuigiLorenzini1 presented his @IMI….
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But this is just an oversimplification,check out the paper and come find me at AAIC if you would like to discuss!.A huge thanks to my coauthors, this was a great group effort.@LECollij @natvilortejedor @CombineLab @FBarkhof @silvia_ingala @bettytijms @JuandoGispert and manymore!.
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We then linked these pathways to multimodal imaging outcomes and found some very specific associations like.Lipid metabolism -> WM integrity.Immune and inflammatory - > cSVD.Cleareance - > WMH
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In this study, we first identified 6 biological pathways within the polygenic risk for AD using a method developped by my friend and colleague Niccolò Tesi
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So thrilled to see our Imaging-genetics paper finally out in A&D!! And even more that this is happening during an amazing AAIC, were we first presented these results last year. 🎈.
alz-journals.onlinelibrary.wiley.com
INTRODUCTION Unraveling how Alzheimer's disease (AD) genetic risk is related to neuropathological heterogeneity, and whether this occurs through specific biological pathways, is a key step toward...
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New study out revealing distinct genetic risk profiles in association with specific pathophysiological aspects in predementia stages of Alzheimer's disease with @IMI_EPAD data!. Congrats to @LuigiLorenzini1 and all authors👏.
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RT @IMI_AMYPAD: This morning, @LuigiLorenzini1 presented at #OHBM2024 in the symposium "Brain imaging genetics in Alzheimer’s Disease: link….
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RT @IMI_AMYPAD: If you're attending #OHBM2024, don't miss today and tomorrow Leo's poster⤵️.Work investigating the cross-sectional and long….
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RT @taviaevans: Hey @OHBM people! This wonderful crew is presenting at D2, 9 am on Thursday. Come shake off your sleep deprivation post clu….
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RT @IMI_EPAD: 🆕paper out investigating main effects and interactions of Alzheimer's disease pathology, APOE-ε4, cSVD and cardiovascular ri….
onlinelibrary.wiley.com
Objective Alzheimer's disease (AD) and cerebral small vessel disease (cSVD), the two most common causes of dementia, are characterized by white matter (WM) alterations diverging from the physiologi...
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A nice work from our team finally out!🧠. Led by Mario Tranfa, we used multimodel selection and latent variable modelling to show the differential impact of vascular and AD-related factors on white matter microstructure.
pubmed.ncbi.nlm.nih.gov
Our results suggest that AD pathology and cSVD exert independent and spatially different effects on WM microstructure, supporting the role of DTI in disease monitoring and suggesting independent...
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RT @eumind_congress: As part of the EU-MIND congress, we are organizing a pre-conference workshop entitled"Getting Started with Neuroimagin….
eu-mind.org
As part of the inaugural European Meeting on Imaging of Neurodegenerative Diseases (EU-MIND), we will be working towards convening a pre-conference workshop entitled “Getting Started with Neuroimag...
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RT @natvilortejedor: 🤩We couldn't be happier! Our symposium on Brain #Imaging #Genetics in AD has been selected to be presented at the @OHB….
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RT @Rosaleena_M: This Friday, @CAR_Karolinska 🧠 imaging seminar for December is pleased to welcome @LuigiLorenzini1 and @MarcoDuering who w….
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RT @taviaevans: As my last act as the Educational Trainee for the @NeuroimagingPIA I began organising a webinar focusing on Imaging Genetic….
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RT @IMI_EPAD: If you’re at #OHBM2023, stop by Mario's & @LuigiLorenzini1's poster to hear about their work identifying longitudinal changes….
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