My recent bioRxiv preprint! We demonstrate an entirely novel way of shielding AAVs from the neutralizing antibodies found in 30-60% of patients - encapsulating the virus inside of an immunologically invisible hollow protein compartment called vault.

Are you a technical founder who wants a better understanding of fundraising in startups? Well, I am too. That's why I wrote up these notes which explore the mechanics and terminology associated with raising rounds. Hope you find this useful as well!.

What do you want to know?.

There are of course a small number of people within the solarpunk sphere (myself included) who aren't anti-progress. But the social 'institutions' of solarpunk now require ideological purity if one wishes to truly contribute to the movement.

Solarpunk masquerades as a technologically optimistic movement when it actually consists of people who are profoundly suspicious of the scientific worldview, technological progress, and anything new and different.

I really like the idea of solarpunk in principle. But it has taken on so much political baggage that one cannot really participate in the solarpunk movement without adhering to ideas of degrowth, human inferiority, and high tech = bad.

My third installment of interesting research papers that I have read over the past few weeks and would like to share with my community. Includes my commentary. Link:

I agree with Alex on everything here. George Church is amazing and this is an unfortunate situation.

Novella Runner-Up. The Lifecycle of Software Objects by Ted Chiang.

Anthology Runner-Up: . Exhalation by Ted Chiang.

Standalone Novel Runner-Ups:. Solaris by Stanislaw Lem.Station Eleven by Emily St. John Mandel.Blindsight by Peter Watts.This Is How You Lose the Time War by Amal El-Mohtar and Max Gladstone.Rendezvous with Rama by Arthur C. Clarke.

Short Story Runner-Ups: . The Last Question by Isaac Asimov.The Server and the Dragon by Hannu Rajaniemi.Blood Music by Greg Bear.Understand by Ted Chiang (part of the anthology Stories of Your Life and Others).

My favorite SF:. Series: Hyperion Cantos by Dan Simmons .Standalone novel: Spin by Robert Charles Wilson.Short story: Utriusque Cosmi by Robert Charles Wilson .Anthology: Stories of Your Life and Others by Ted Chiang.Novella: True Names by Cory Doctorow and Benjamin Rosenbaum.

(2/2) By doing so, we could train AI systems to help new companies through the FDA submission process and avoid pitfalls, streamlining and accelerating biomedical translation!. So, it is good to see this article pushing for the idea!.

At the @foresightinst AI x Bio conference, I took part in a working group where we suggested something very similar: establish a fund to buy the FDA submission documents from 'dead' biotech companies as a source of AI training data (1/2).

RT @daatdarling: We need to re-normalize being an autodidact, you can study things to a high level on your own, and you can continue studyi….

RT @AllenInstitute: Holy Soma Batman!. You never know what you may find when you cruise our MICrONS Explorer, such as a blood vessel pierci….

Read this some time ago, but worth sharing again!.

Great paper which combines expansion microscopy and in situ genome sequencing to map chromatin structure and selected protein targets in cellular nuclei. ExIGS was then used to explore how nuclear lamin protein and genome organization changes during aging.

Despite the title, this article is hopeful about the future of AAVs. Advances in tech that lowers doses and decreases toxicity may lead to a stronger industry in the end. Most importantly, this will bring lifesaving cures to patients who need them.

An excellent read on platform biotech companies, why they are difficult, and what to hope for in the future that may make platforms more feasible. Link to the Substack article:

Link to the original paper: Model of neurovascular coupling and gap junction signal transmission proposed by Krolak et al.