Lizzy Smyth
@LizzySmyth1
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Medical Oncologist. Cancer Clinical Trials @OxfordCancer #GIcancer #ESMO #EORTC
Oxford, England
Joined October 2019
This is, to my eyes, one of the most exiting abstracts from @myESMO #ESMO25 #Presidential
#PRAME, expressed in many tumours ๐ #AdoptiveCellTherapy achieves a ๐ORR (67%)๐ฅณ Proof of concept โ
Expand concept to other tumours? New target of interest? #ESMOAmbassadors
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#ESMO25 AGITG DYNAMIC-III: ctDNA-guided adj ChT de-escalation in stage III CC ๐ 968 pts | 72.5% ctDNAโ | 3y RFS 85.3% vs 88.1% (NI not met) ๐ Oxa 34.8% vs 88.6% | Grโฅ3 AEs 6.2% vs 10.6% ๐ฏ De-escalation feasible, reduced toxicity with similar outcomes in low-risk (T1โ3N1)
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RT @DrChoueiri: Powerhouse masterful discussion by @GIcancerDoc! Cuts through noise, pressures the stats, and maps where this actually fitsโฆ
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Year 2 of #ESMOGI #oncology journal editorial board hard at work @esmo #ESMO25 @ben_irit @KarynAGoodman @RachelRiechelm2 Drs. Florian Lordick, Thierry Andre, Anelisa Cotinhu and so many others! We would love to consider your #cancerresearch for publication. #cancer
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Irish connections #ESMO25 presidential dinner from Medical school @UCC to UAE, Beaumont & St Jamesโs hospital to @pmcancercentre & @TheChristieNHS @LizzySmyth1 @graokane
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KRAS G12D inhibitors work in #PDAC! More confirmatory data of this presented at #ESMO25 @myESMO I am so so happy to see these waterfall plots ๐ ๐GFH375-VS7375 mono ๐HRS4642 with GemNabPaclitaxel Great discussion by #MaeveLowery KRAS - easy to test! ๐ฅณ๐ฅณ #ESMOAmbassadors
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# ESMO25 Clinical Practice Guidelines 1 @LizzySmyth1 @ArndtVogel : access the full guidelines https://t.co/Srrj4buTA6
annalsofoncology.org
This European Society for Medical Oncology (ESMO) Clinical Practice Guideline (CPG) focuses on invasive cutaneous melanoma. The management of uveal melanoma and non-melanoma skin cancers are descri...
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Great ESMO Guidelines session with @ArndtVogel & @LizzySmyth1 on #HCC. We discussed intermediate-stage challenges, 1L vs 2L decisions, and how national approvals & reimbursement shape real-world practice โ still many questions to answer! #ESMO #LiverCancer #MyESMO ๐ฉ๐ช
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Next up: learn the latest in #melanoma and #HCC with the fabulous @TeresaSAmaral and @ArndtVogel
#ESMO25 Guidelines Session 1 When: โฐ 10.15am (that means you need to start walking now!) Where :๐7.1 Ground Floor Bonn 7.1c See you soon! @myESMO #ESMOAmbassadors
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๐ข Calling all oncology AI users (that'll be all of us then...) Use this tech the right way! @myESMO gives the first guidance framework for AI in the clinic #ELCAP Very proud to work with an awesome team led by Jakob Kather on this innovative project. Launched at #ESMO25 ๐ช
The ESMO Guidance on the use of #LargeLanguageModels in #ClinicalPractice (#ELCAP) is out: the first structured set of recommendations to bring #AI language models into #oncology safely and effectively. #ESMOAI25 #ESMO25 #LLMs #HealthAI ๐ https://t.co/joRvSI7cLz
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Practice-shaping presidential caliber from @Prof_Nadia_H! DESTINY-Breast11: neoadjuvant T-DXdโTHP tops ddAC-THP on pCR 67.3% vs 56.3% (ฮ11.2%, p=0.003). Early positive trend in EFS. #ESMO25 #BreastCancer @myESMO @Annals_Oncology @DanaFarber
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The @myESMO Presidential I, happening in 30 min at Berlin auditorium! Practice-changing data presented ! @curijoey @stolaney1 #ESMO25
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#ESMO25 ?TDxD challenger? Bispecific HER2 anbenitamab shows promise in trastuzumab resistant #gastriccancer. โ
No ILD... Small study. ๐จ๐ณ only. Need larger international trials but this is encouraging... #ESMOAmbassadors
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We have seen the mountain โฐ๏ธ top! MATTERHORN OS #ESMO25 OS continues to โฌ๏ธover time (~7% 3y) Benefit independent of PD-L1 Enough now to adopt as SOC? #ESMOAmbassadors
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And we're off!! #ESMO25 opening ceremony ๐๐๐ ๐ Berlin Auditorium now! #ESMOAmbassadors
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Adding the finishing touches ๐ฉโ๐ป to my presentation for tomorrow at #ESMO25 ... Team Upper GI - I promise not to talk about PD-L1 (again!) 16:00 ๐ Munich Auditorium. See you there! #ESMOAmbassadors #CancerResearch
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Here we go again.. #ESMO25 โ๏ธ๐๐ Get to Berlin early ๐ for the UGI orals Friday 17/10 afternoon.. I'm watching out for the Matterhorn โฐ๏ธ update...will we see an OS benefit ๐? See you this day next week! #ESMOAmbassadors
#ESMO25: Discover the latest #CancerResearch insights brought to you by #ESMOAmbassadors and join the conversation in #oncology. ๐ https://t.co/YZZN0sQyBS
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#ESMO25: Discover the latest #CancerResearch insights brought to you by #ESMOAmbassadors and join the conversation in #oncology. ๐ https://t.co/YZZN0sQyBS
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Cancer care is more than biomarkers... Grateful ๐ for the opportunity expand my oncology horizons ๐
writing this essay with Laura Nimmon and Gary Rodin.. Broadening our view of power in clinicianโpatient relationships in oncology - The Lancet Oncology
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