Link Lab
@LinkLabs
Followers
1K
Following
210
Media
23
Statuses
129
We study and engineer microbial metabolism! Located at the University of Tübingen @uni_tue *The account is run by lab members
Tübingen, Germany
Joined November 2018
We are searching PhD students in synthetic biology and metabolic engineering
1
4
8
Great collaboration with the @sourjik lab. Check out how isoprenoid biosynthesis, high oxygen and a membrane complex influence E. coli fitness 👇.
Our paper describing importance of a highly evolutionary conserved membrane-organising protein complex in bacterial respiration is now published in PLoS Biology in its final version Congratulations @MariaIsa_perezl !.
0
0
1
Our CRISPR screen in E. coli shows that metabolic mutations influence antibiotic action. Pathway-specific bottlenecks cause resistance. Slow growth leads to tolerance. Read more 👉
0
5
26
New paper from our group: we developed intact protein barcoding, which uses small proteins as a barcode to identify CRISPRi strains with mass spectrometry.
1
6
20
Our group was featured in the key to my research podcast. There is a short version and a deep dive about our research and episodes with other great scientists from @uni_tue, @Gh_Tabatabai, @EKemen. Check it out:
0
1
3
RT @gasb_synbio: Don't miss the #GCSB Conference⏰! With less than a month to go, it's time to secure your spot and explore the latest adva….
0
9
0
0
0
1
Controlling bacteria, controlling metabolism, and why this is relevant for antibiotics. The #exzellenterklaert podcast featured our research, together with my colleague @NadineZiemert. Thanks to Larissa and team and to @CoE_CMFI . In German:
0
5
16
Great collaboration with the Milo Lab. Not much is needed to reprogram E. coli metabolism for autotrophic growth:
0
6
24
We wrote a preview about a mobile CRISPRi library from the Brown Lab. Great tool to explore the different "shades" of gene essentiality:
0
12
43
RT @MolSystBiol: 10/2023 Issue ➡️ On the cover (by @TeamSciStories): Genome-scale mapping or temperature-sensitive….
0
3
0
Turning up the heat on essential genes🌡️ Thanks @StirlingLab for this very nice comment about our thermo-switches. AcCoA switches would indeed be a very nice thing.
0
2
9
RT @JoergLab: Save the date! March 21-23 next year, please join me and Nassos Typas @TypasLab and Ruth Ley @RuthLeyMicro for this big micro….
0
41
0
New paper from our group. We made 15,120 E. coli mutants and screened them for temperature-sensitivity. The thermo-switches are great tools to control bacterial metabolism and growth. 👇.
0
18
53
New preprint. We found that ATP limitation makes E. coli resistant to some antibiotics because it induces expression of a transporter (PunC). This happens also in E. coli from the clinic.
0
8
29
New preprint. @ThorbenSchramm made an E. coli CRISPR library🧫 and screened for temperature sensitive mutants. Some of them are great growth switches.
0
14
46