The above video shows leukocytes streaming into the CSF across the ChP following inflammation in a mouse model of meningitis. We found that ChP epithelial cells actively recruit these immune cells via a concerted set of signaling steps: 2/
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Do immune cells enter the inflamed adult brain via the choroid plexus (ChP)?🤒 Our
@biorxivpreprint
led by
@Huixin_BJ
shows leukocytes crossing the ChP in real time & reveals molecular mechanisms w/ scRNAseq master
@plotfy33
. 1/
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ChP epithelial cells:
1. recruit peripheral immune cells with chemokines & adhesion molecules,
2. allow trafficking by producing matrix metalloproteases that loosen the epithelial barrier, and
3. secrete survival & differentiation factors to resolve inflammation. 3/
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Failure to maintain optimal levels of neuroinflammation, including at the ChP, drives pathology for a growing # of neurologic conditions. Our work provides a roadmap to understand neuroinflammation at a critical brain barrier and will apply to a range of brain pathologies. 🧠4/
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This work was collaborative and we are extremely grateful to those who contributed to this project, including
@ordovas_PhD
,
@Andermann_Mark
,
@IsaacChiuLab
,
@Aja_Claire
,
@chehnly1
,
@mezawadzki
,
@Jin_Cui_
,
@liwen_deng811
, and
@belle_faite
. 🔬 /end
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