Lars Lau Raket
@LarsRaket
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Statistician and data scientist working with brain disorders 🧠📈 Views are my own.
Copenhagen, Denmark
Joined March 2012
My paper on statistical disease progression modeling in Alzheimer's disease has just been published in @FrontAIBigData. You can find it here Want to try it out on your own data? Code can be found here
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RT @OwainEvans_UK: New paper & surprising result. LLMs transmit traits to other models via hidden signals in data. Datasets consisting only….
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RT @_michael_scholl: Our most important paper, out now! A massive international collaboration, led by @AlexisMoscoso9, featuring over 6500….
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"A romantic vintage couple in bold comic-style attire embracing on a balcony under a starry night sky.". Try Grok Imagine, free for a limited time:.
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RT @rocketjohnsen: There is now something new under the sun: you can literally experience a completely new perceptual color that no one has….
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RT @OskarHansson9: New Alzheimer blood biomarker! .Plasma eMTBR-tau243 correlates strongly with tau tangle pathology, brain atrophy and cog….
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RT @_michael_scholl: Always my favourite post at the beginning of the year:. Registration for our course “Biomarkers for neurodegenerative….
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RT @_michael_scholl: Excited to share the REAL AD design paper, now out in @alzdemjournals . The study has been live for 5 months, and we a….
alz-journals.onlinelibrary.wiley.com
Early diagnosis is crucial to treatment success. This is especially relevant for Alzheimer's disease (AD), with its protracted preclinical phase. Most health care systems do not have the resources...
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RT @OskarHansson9: Interested in the density of regional tau pathology that is needed for tau-PET to reliably detect it? Here we performed….
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RT @maude_wagner2: A friendly reminder that our @ISTAART @DesignDataPIA All Member Meeting is happening tomorrow (Tuesday 09/10) at 2 p.m.….
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Thank you for the collaboration @AntoineLeuzy, @vincentDore2, @OskarHansson9, @susivak, and everyone else who contributed to this!! [7/7].
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This paper was the result of a monumental collaboration and data sharing effort in the Tau PET Harmonization Working Group led by the @CPathInstitute and includes representatives from academia, regulators, and industry from all over the world [6/7].
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The JPM is open source and can be downloaded here: [5/7].
github.com
Joint Propagation Model. Contribute to larslau/JPM development by creating an account on GitHub.
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Since there is no reference tracer in the model, we needed to develop a model where signal and uncertainties are propagated through the model in a controlled way. We named this model the joint propagation model (JPM) [4/7].
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The specific properties of tau PET data led us to develop a novel harmonization model that can derive mapping equations based on a given set of anchor-point subjects and head-to-head tau PET data [3/7].
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The paper describes the methodology we developed to harmonize tau PET data and demonstrates the feasibility of mapping tau PET quantifications from 5 different tau PET tracers to a single harmonized scale (the CenTauR scale) [2/7].
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I'm happy to share our paper on harmonizing tau PET in Alzheimer's disease that was just published in Alzheimer's & Dementia 🧠📈 🚀 .🧵[1/7].
alz-journals.onlinelibrary.wiley.com
INTRODUCTION Tau-positron emission tomography (PET) outcome data of patients with Alzheimer's disease (AD) cannot currently be meaningfully compared or combined when different tracers are used due...
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RT @RikOssenkoppele: @EmmaCoomans just presented our large-scale tau PET study (>11,000 participants from 41 cohorts) providing robust prev….
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RT @nvillain_alz: 🚨🚨 Paper alert 🚨 🚨.I am honored to have been part of this article led by @LarsRaket. The article provides very important….
alz-journals.onlinelibrary.wiley.com
INTRODUCTION Recent clinical trials of amyloid beta (Aβ)-targeting therapies in Alzheimer's disease (AD) have demonstrated a clinical benefit over 18 months, but their long-term impact on disease...
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RT @RikOssenkoppele: Harmonizing tau PET in Alzheimer’s disease: .The CenTauR scale and the joint propagation model. A first step towards a….
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