Alex Lander
@LanderAJ95
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SNSF PostDoc Fellow @ Universität Basel | Peptide Enthusiast
Basel, Switzerland
Joined March 2020
Excited to share our work on @ACSCentSci! We used acetlylysine to replace Lys73 of OXA-48 and showed NaCl altered the antibiotic effectiveness by promoting a newly discovered inactive acyl-enzyme intermediate.@YuanHe_NWU @the100footpole @JinGroupMIB
pubs.acs.org
Antibiotic-resistant Enterobacterales that produce oxacillinase (OXA)-48-like Class D β-lactamases are often linked to increased clinical mortality. Though the catalytic mechanism of OXA-48 is known,...
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Another racemic crystallography project combined with beautiful work on folded synthetic D-peptide and phage display, in an international collaboration with @LukGroup @LanderAJ95 and Chuanliu Wu's Group at Xiamen University.
Synthetic & Refolding Strategy of a Cysteine-Rich Domain in Tumor Necrosis Factor Receptor for Racemic Crystallography Analysis & D-Peptide Ligand Discovery By Yi Jin, Chuanliu Wu, Louis Luk et al @cardiffuni @JinGroupMIB 🔓 In ACS Bio & Med Chem Au 👉 https://t.co/oRcRcWjEpD
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The latest publication from my PhD work at Cardiff 💎 a great collaborative effort with some incredible scientists!
.@LukGroup
@JinGroupMIB @Chemtips & @LanderAJ95 probe the tryptophan interactions of aureocin A53 with phospholipid mimics by racemic protein crystallography. @ChemistryCU
@UoMMIB
@Concordia. https://t.co/zoCOV7e0JN
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I'm absolutely thrilled to announce that my new book, Building Skills in Organic Chemistry, is now available from Amazon as a Kindle (£6.34), black and white paperback (£18.00) and colour hardback (£65). Please retweet this to let everyone know! 1/2 https://t.co/86FcqCFDx9
amazon.co.uk
Organic chemistry gets a lot of bad press! It is widely perceived to be a ‘difficult’ subject to learn – a mythical list of reactions to memorize. This book takes an ‘active’ approach to helping you...
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Passed my PhD viva today 🥳 Very excited for my next chapter as postdoc in the molecular pharmacy group of @UniBasel_en 🇨🇭
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Plz RT 🙏. A new PhD position is available to join @JinGroupMIB (UK candidates only) studying Cysteinolic Acid Metabolism in Marine Algae and its Fate in Humans. This exciting opportunity also allows spending 1 year at Uni of Melbourne in @sjwill99 Lab
manchester.ac.uk
Research. Teaching and learning. Social responsibility. Discover more about The University of Manchester here.
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Our work with @the100footpole @YuanHeNWU on explaining the biphasic kinetics of OXA-48-like carbapenemases caused by chloride is out. "Discovery and molecular basis of chloride as an allosteric activator and catalytic inhibitor for Class-D lactamases"
biorxiv.org
Oxacillinase (OXA)-48-like carbapenemases are epidemic class D β-lactamases in Enterobacterales , resulting in high mortality. Though the chemical mechanism has been clearly established, for decades,...
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D-Peptide and D-Protein Technology: Recent Advances, Challenges, and Opportunities (Jin, Luk) @ChemistryCU, @LukGroup, @JinGroupMIB, @LanderAJ95 #openaccess
https://t.co/15KI1cEhfr
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Our review contribution on "D‐Peptide and D‐Protein technology: Recent advances, challenges, and opportunities" with @LanderAJ95 and @LukGroup
chemistry-europe.onlinelibrary.wiley.com
D-protein enantiomers can be accessed through total chemical synthesis and their preparation enables establishment of mirror-image life, structural analysis through racemic protein crystallography...
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🌟 Our first @RSC_PPSG online seminars are from @Thomson_Lab at @UofGChem and @TheRubiniGroup at @ucdchemistry on Oct 7th 1 pm encompassing binder design and PTM analysis (!).🌟 Please register this online lecture!
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Hello #peptide and #protein science people and welcome to our new @RSC_PPSG Twitter feed! Thanks for following. 📖 We will be hosting a new series of monthly early career online seminars on every 1st Friday at 1pm. More info to follow 👀… @RoySocChem @RSC_CBBG @EurPepSoc
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If you are interested in the mirror-image world, here is our review on the latest advances on D- proteins and peptides @LukGroup
@LanderAJ95
https://t.co/23ozWl3mWI
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Kindly, please RT. Seeking a BBSRC-funded #postdoc on designing a novel protein labelling reaction backed by our track record and pilot data. Expertise in #peptide #chemistry or #enzymology is desired. Anyone interested, please apply ⚧️🇺🇦🇪🇺🇬🇧
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Couldn’t figure out where all of my marker pens were going. Meanwhile in my car…
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2022 has been a milestone of mine for a long time 🎓Hopefully a big year ahead and wishing everyone the best new year 🎉
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Our ongoing artificial enzyme project, also the last Xmas gift from my first postdoc @ANoedling thanks for everyone's input @vicente_moliner, @JinGroupMIB @MorrillGroup @swiderek_k
https://t.co/66d7Nki42l
pubs.rsc.org
Here, we combine the use of host screening, protein crystallography and QM/MM molecular dynamics simulations to investigate how the protein structure affects iminium catalysis by biotinylated...
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a #PhDposition in D-peptide design - a mix of #peptide #chemistry, #computational design and high-throughput #screening It will be highly interdisciplinary, fun and challenging project. Please apply within. https://t.co/LoGM2FxUvz
findaphd.com
PhD Project - PhD in Chemistry: D-novo minibinders: developing a high throughput platform for computational design and production of tailored synthetic proteins at Cardiff University, listed on...
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