WestermannLab
@LabWestermann
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Based in Essen, Germany at @unidue, we are interested in chromosome segregation during mitosis in budding yeast
Essen, Nordrhein-Westfalen
Joined August 2019
We are excited about this study as multiple studies had suggested that such an outer kinetochore receptor for Aurora B must exist. We feel it’s an important step towards understanding how Ipl1/Aurora B achieves tension-dependent substrate phosphorylation at the outer kinetochore.
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Alex shows that the mutant is very sensitive to a reduction in Ipl1 activity. However, it can be rescue it by recruitment of active Ipl1 to KMN in vivo. Biochemically Ipl1-Sli15 binds reconstituted KMN via Spc105-Kre28 in vitro, the binding is counteracted by Ipl1 phosphorylation
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Alex’ work describes a new mutant in the outer kinetochore KMN subunit Kre28/Zwint. This allele is intriguing because it resembles mutants in the tension-dependent error correction pathway such as ipl1, sli15 or sgo1.
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We are excited to share our latest work in context of the colaborative research consortium 1430 @Crc1430. A preprint is available on bioRxiv ( https://t.co/IqSKQcvIOR).
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Errors during cell division can have dire consequences. If you are interested in understanding how kinetochores and the microtubule cytoskeleton work together to allow faithful chromosome segregation in mitosis apply to @LabWestermann @IMPRS_LM. #PhDposition #celldivision #IMPRS
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Spread the word! @unidue is seeking a junior #professor for #cellularbiochemistry at the Faculty of Biology @unidue_zmb. ➡️ https://t.co/1wtZ2tTJtd
#facultyjobs #academicjobs #sciencecareers #TenureTrack
nature.com
We are seeking an excellent early career researcher in the field of mechanistic cell biology.
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Excited to share my first first-author paper. Our work @hemmo_lab on lysosomal damage sensing and lysophagy initiation is out in @MolecularCell
https://t.co/gvtInJAgKt. Here we show how cells triage damaged lysosomes for lysophagy via lipid-packing defect sensing by SPG20/Spartin
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On our way to #cellbio2023. Visit us at our posters P2643, P2645 and P2670 on Tuesday 12:15-15:15. We are happy to discuss our research with you.
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Welcome to our new PhD student @Sonja_Hbrkrn, who will work on the fate of inner kinetochore subunits.
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Excited to share our latest preprint, excellent work by Emily and @erinejenson! Extensive mutagenesis of the Ndc80c revealed a very busy 'interaction hub,' vital for Mps1 binding and competitive regulation of localization:
biorxiv.org
Accurate chromosome segregation relies on kinetochores carrying out multiple functions, including establishing and maintaining microtubule attachments, forming precise bioriented attachments between...
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Our work sheds new light in a mechanism how end-on attachment maturation can regulate the recruitment of Mps1 and shows the tight interconnection between error correction and the spindle assembly checkpoint.
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The surface on Ndc80c that binds Mps1 also serves as interface for the Ipl1 regulated engagement of Dam1 at bi-oriented kinetochores. Dam1 competes with Mps1 in vitro and Dam1 mutants that mimic Ipl1 phosphorylation cannot displace Mps1 efficiently.
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One conserved feature of the interaction is that it is negatively regulated byMps1 autophosphorylation. We mapped autophosphorylation sites in Mps1 and showed that phosphorylation contributes but is not sufficient for the release of Mps1 before anaphase.
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In the manuscript, define a binding interface of Mps1 on Ndc80c, located on the backside of the CH-domains. Point mutations derived from the structure impair the Mps1:Ndc80c interaction in vitro and generate in Mps1 separation-of-function alleles in vivo.
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We are excited to share our latest preprint on BioRxiv ( https://t.co/mQD0lJVvh2). Together with @AndreaMusacchi1 we investigated the regulated recruitment of Mps1 to the budding yeast kinetochore and propose a model that puts Mps1 localization under indirect regulation of Ipl1.
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We have an opening for a #PhD Position. Apply now to join us @WWU Münster and work on an exciting #cryoEM project with focus on the interplay between pore forming toxins and receptors at the synaptic interface @SFB1438. RT appreciated
Are you interested in #cryoEM of membrane proteins? Do you want to be part of a lively research network @Sfb1348 @WWU_Muenster? We are looking for a highly motivated and talented phd student to join our shiny new lab in lovely Münster! Apply now! https://t.co/84YI65Dg3Y
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What a challenging but also exciting year! Three finished PhD theses, great publications and a nice Christmas party with all lab members. We wish you all Happy Holidays and a Happy New Year 🎁🎄🎊 #kinetochoreandmore #PhDone #HappyHolidays #glitter #celebration
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Congrats to Alex for defending his PhD thesis 🥳🥂🎉 well done! #kinetochoreandmore #number11 #siewerdensoschnellgroß #explosion
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