Sakai Disc Lab
@LabSakai
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Dai Sakai's research team specialized in #regenmed therapies for IVD repair and deformity corrections. Maintained by @iDeJordy
Japan
Joined June 2021
It was time for a #groupphoto update. So #inspired and #motivated by all these fantastic and hardworking researchers. Also great to see @LabSakai is becoming more and more international. Expect more great things to come your way very soon. 😉
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It is truly inspiring to witness the collaborative efforts between our societies and the incredible reach we achieve as scientists through these partnerships.
Calling all @OrsSpineSection Members! . 🤝 To our friends @OrsSpineSection:. We’d love to see you at #ISSLS2025 in Atlanta!.🔹 Collaborate with the global spine community.🔹 Present your groundbreaking work.🔹 Propose exciting joint symposia. Let’s strengthen our partnership!
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RT @ISSLS_Society: Calling all @OrsSpineSection Members! . 🤝 To our friends @OrsSpineSection:. We’d love to see you at #ISSLS2025 in Atlan….
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New study in @JORSpine exploring #HybridSurgery combining cervical disc #arthroplasty and ACDF offered biomechanical benefits in revision surgery, especially with D-C-D models. Great insights for hybrid surgical strategies! @OrsSpineSection . Read it here:
onlinelibrary.wiley.com
This finite element study Innovatively investigated the biomechanical characteristics of hybrid surgery to treat two-level discontinuous ASD in ACDF revision surgery. The results indicated that...
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New @JORSpine work on "Spine Tester TO GO"! .This innovative tool enables both biomechanical & biological tests on the same specimen, reducing the need for animals & supporting the 3R principle. 🐭🐷🐶. Find work here: 🔗 @OrsSpineSection @ORSPCMSection.
onlinelibrary.wiley.com
Biomechanical testing after spinal animal experiments is often neglected because testing machines for flexibility measurement are large and difficult to transport, and the same specimen can only be...
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RT @OrsSpineSection: Looking forward to seeing everyone this Wednesday at our annual social hour! Registration link below!.
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New @JorSpine study identifies IVDD #biomarkers. 🔬 Using advanced #bioinformatics, researchers found 10 hub genes, with #JUNB, #SOCS3, and #CEBPB emerging as top candidates. New diagnosis and therapeutic targets? 🧠💡. 🔗 Read more: @OrsSpineSection.
onlinelibrary.wiley.com
Intervertebral disc degeneration (IVDD) is an age-related orthopedic degenerative disease characterized by recurrent episodes of lower back pain, the pathogenesis of which is not fully understood....
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RT @ISSLS_Society: A reminder that registration and abstract submission are now open for #ISSLS2025. Categories include: .👉 Non-Surgery .👉….
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RT @arnoldwongPT: Honored to be involved in this NIH-funded study uncovering a link between gut microbiome dysbiosis and lumbar degenerativ….
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New @JORSpine study suggests a link between gut microbiome dysbiosis & lumbar degenerative spondylolisthesis! Patients with LDS showed distinct gut bacterial patterns, including more pro-inflammatory taxa. Could gut health be key to spine care? 🤔. 🔗
onlinelibrary.wiley.com
This study is the “first” to report a significant association of gut microbiome dysbiosis and the association with lumbar degenerative spondylolisthesis in symptomatic patients, noting pro-inflamma...
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📝 New study in @JorSpine underlines link IDD and Tnf-α/Tnfr signaling pathway. Tnfr1/2 #knockout mice showed #TNFR deficiency alleviates age-related and spine instability-induced IDD by enhancing ECM metabolism. See: @OrsSpineSection @ORSPCMSection.
onlinelibrary.wiley.com
The study demonstrate a critical role of the Tnf-α/Tnfr signaling in promoting age- and LSI-induced IVDD in mice. Targeting this pathway may be a novel strategy to prevent and treat IVDD development...
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RT @ISSLS_Society: 🚨 Exciting News! 🚨. The #ISSLS2025 registration & abstract submission is now open! . This year’s meeting will be held in….
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New in @JORSpine: A dual-model #AI system for #LDH patients automates muscle segmentation and fatty infiltration (FI) annotation on #MRI, showing shows high accuracy in paraspinal muscle and FI assessment compared to traditional methods! . 🔗
onlinelibrary.wiley.com
Our study developed a deep learning model for automated muscle segmentation and fat annotation on MRI to aid lumbar disc herniation assessment. The model demonstrated outstanding performance, with...
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🔧 New study @JORSpine: A #DeepLearning model accurately identifies pedicle screw brands from spine radiographs, aiding preoperative planning in revision #spinesurgery. The AP+Lateral ensemble model achieved 94% accuracy, matching experienced surgeons! .🔗
onlinelibrary.wiley.com
The AP + Lateral ensemble model had the most stable performance in terms of accuracy, F1 score, and AUC. The performances of the ensemble models were comparable to that of experienced orthopedic...
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New @JORSpine: .A new U-Net model automates 3D disc segmentation from spine MRIs, matching manual accuracy and streamlining analysis across diverse ages and degeneration levels. #AI #MRI #MedicalImaging @OrsSpineSection .
onlinelibrary.wiley.com
The study successfully trained a U-Net model for automatic slice-wise segmentation of 3D disc volumes in a population with a wide range of age and disc degeneration and measured a small decrease in...
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New @JORSpine review on #Curcumin's potential to mitigate spinal cord injury complications by modulating key inflammatory pathways like #Nrf2, #NFkB, and #TGFβ. 🌿 Could curcumin be the future of SCI treatment? . Find out more:
onlinelibrary.wiley.com
Neurodegenerative diseases are characterized by slow progressive loss of neuronal cells in the central nervous system (CNS), which can affect different areas in the brain. Anti-inflammatory compoun...
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New @JORSpine review examines discogenic #backpain and explores how biomolecular therapies could target pain pathways beyond IVD degeneration showing the need for therapies addressing chronic LBP. Learn more: @OrsSpineSection.#SpineHealth #BioMolecular.
onlinelibrary.wiley.com
Most therapeutic approaches aimed to target disc degeneration focus on repair and regeneration and neglect chronic pain. Biomolecular therapies are based on acute intervertebral disc degeneration...
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RT @ISSLS_Society: Applications are open to join @ISSLS_Society! Be part of a global network of spine research leaders advancing #LumbarSpi….
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Study in @JORSpine reveals how ligamentum flavum degeneration contributes to spinal stenosis; key changes in tissue structure, composition, and biomechanics. 🧬 .Learn more: #SpineHealth #Orthopedics.
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📄 Read the paper: #RegenerativeMedicine #SpineResearch #CellTherapy #RegenMed #BackPain .@OrsSpineSection @ISSLS_Society.
mdpi.com
Cell transplantation is being actively explored as a regenerative therapy for discogenic back pain. This study explored the regenerative potential of Tie2+ nucleus pulposus progenitor cells (NPPCs)...
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Despite similar #Tie2 positivity rates, older NPPCs showed significant differences in #GD2 positivity and proliferation. Highlighting the need to consider age in cell-based therapies. Dive into the full study for more on optimizing methods and implications for IVD #regeneration!.
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