Just applied to be a mentor for @NSURPorg , great initiative for fully virtual, paid summer internships! #NoLabNoProblem.

RT @azinasuhi: Exited to share our latest review paper in Microbiology and Molecular Biology Reviews, led by @ewald_lab and @LabMccall . Th….

RT @All_Microbiomes: Rutgers Health will be launching two new Open Rank recruitments this month for Tenure-Track or Tenured faculty positio….

RT @zinghomer: We are recruiting a Mass Spectrometry Analyst to work on clinical and biological projects, contributing to @EdinburghCRF cli….

RT @ByronPurse: @SDSU Chemistry and Biochemistry is accepting applicants for our Ph.D., M.S., and M.A. programs for Fall 2024. The first pa….

@OUResearch @SDSUResearch @BCM_TropMed.⁩@TexasChildrens.⁩.

With: Yi Xiong, Shelley Kane, London Klechka, Kate Wheeler, Michael Jimenez Sandoval, Mahbobeh Lesani, Ekram Hossain, @MitchelleKatem3, Miranda Schaefer, Morgan Harris, Sayre Barron, Chongle Pan, April Kendricks, Ana Carolina Leão, Krithivasan Sankaranarayanan, Jeroen Pollet.

Led by first authors @liu_zongyuan Danya Dean, Jarrod Roach, @neurons_n_naps . Tagging the rest ASAP! 10/.

This was work with fabulous co-corresponding author Kathryn Jones, and collaborators @PeterHotez @mebottazzi ⁦@BCM_TropMed.⁩ ⁦@TexasChildrens 9/.

We wrote a blog post about it: 8/.

We also showed that some metabolic pathways are harder to restore than others: opportunities for new interventions and the development of combination strategies! 7/.

A key driver is persistent inflammation, because a therapeutic vaccine (developed by our collaborators at Baylor College of Medicine, tagged below) provided superior metabolic restoration. 6/.

and that it also does not fully restore urinary metabolism (read it here: , even in mice where all parasites are cleared. This also provides a non-invasive way to evaluate better drugs in the future. 5/

In parallel manuscripts, we show that chronic stage treatment with the antiparasitic benznidazole only leads to incomplete cardiac metabolic restoration (read it here: 4/

Whereas early antiparasitic treatment can prevent disease. Irreversible cardiac fibrosis plays a role, but is it the only factor? What about metabolism? We knew from our prior work that modulating metabolism on its own could change acute infection outcome (PMID:32766448) 3/.

We've been interested in investigating the role that metabolism plays in clinical failure, using Trypanosoma cruzi and Chagas disease as a biological system. In Chagas disease, if treatment is delayed to advanced symptomatic disease, patients still die 2/.

What are the different ways for infectious disease treatment to fail? We're familiar with antimicrobial drug resistance, where the pathogen fails to be killed by your drug. Another important scenario, however, is clinical failure, where the pathogen dies but symptoms persist. 1/.

@WiParasitology @PiParasitology @ASMicrobiology.

Reach out with questions, and apply here:

If you have experience in rodent models and in cell culture and want to expand your skillset, consider applying! You'll get training in cutting-edge mass spectrometry-based metabolomics. If an industry career is your goal, there's loads of networking opportunities in San Diego.