A/Prof Lee-anne Chapple
@LSChapple
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Senior Critical Care Dietitian, Royal Adelaide Hospital | Research Fellow, University of Adelaide
Adelaide, South Australia
Joined July 2014
Career highlight!. Honoured to present @ProteinTarget with @msummo2 at @CritCareReviews in Belfast. You can read all about the trial in JAMA:. Or watch the full recording at: .
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Great way to end a busy fortnight of conferences!.
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RT @JAMA_current: Augmenting enteral protein did not improve outcomes for critically ill patients compared with standard protein levels in….
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3. Lower protein doses (1.2g protein/kg/day) increased to goal over the first 4 days of ICU should be considered. 4. Future work may target the time to ⬆️ protein doses, given the impact of lower protein dose on muscle mass/malnutrition, potentially guided by urea levels.
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My interpretation: .1. Short-term early higher dose protein feeding does not impact outcomes in critically ill patients. 2. Caution should be taken particularly for patients with an AKI at baseline.
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For sub-groups, there was heterogeneity of treatment effect in those receiving mechanical ventilation (P = 0.02; very low credibility) and those receiving new kidney replacement therapy at baseline (P < .001; moderate credibility).
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Blood urea increased from day 1 to 10 from 7.3 to 13.0 in the augmented group to 7.5 to 10.6 in the usual care group.
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For the primary outcome, there was no difference in number of days free of the index hospital and alive at day 90: augmented protein: 62 (0-77) vs usual protein: 64 (0- 77) days; median diff -1.97 (95% CI -7.24, 3.30). There were no differences in any secondary outcome.
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3397 patients (64% M, ~61y, ~80% IMV, APACHE 19, BMI 27) were recruited with high trial compliance. Mean protein doses (noted this data is for a subset of patients only) were lower than previous trials and with a mean duration of feeding of ~3.5 days.
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We conducted a cluster randomised, double-crossover, clinical trial comparing augmented (Nutrison Protein Intense 100g protein/L) versus usual protein (Nutrison Protein Plus 63g/L) delivery in all patients receiving enteral nutrition in ICU. 8 ICUs participated for 12 months.
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RT @ICUnutrition: Meta-analysis mentioned in the @ProteinTarget editorial- shows harm in sub-group. Also shows signal for improved physical….
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RT @ICUnutrition: Seminal work by @LSChapple and team mentioned in the @ProteinTarget editorial #ccr25 . Muscle Protein Synthesis after Pro….
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Such a pleasure to present the @ProteinTarget trial at this incredible venue.
Very proud to be here as part of the @ProteinTarget study team and support @LSChapple @MelbourneICU and Matt Summers @sandrapeake01 . Augmented Enteral Protein During Critical Illness #CCR25
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RT @CritCareReviews: 🚨 ENCOMPASS TRIAL Results at #CCR25🚨. 📍 8 hospitals.👥 4032 patients.📊 Stepped-wedge cluster RCT. 🎯 Tests STAR: nurse-l….
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Looking forward to presenting the results of @ProteinTarget in June. What a great line up for the editorial/panel!.
#CCR25 opens with the #TARGETprotein results. Is additional protein beneficial in the critically ill?. Join @LSChapple @msummo2 & @MelbourneICU to find out. Editorial - Angelique de Man. Panel - @Zudin_P @StephptaylorCLT & Monica Taljaard. Register at
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Congratulations to all Vars candidates and the final award winners. Women powerhouse! 👏🏻.
Today’s Premier Paper Session & Vars Award Competition highlighted the best peer-reviewed research abstracts from #ASPEN25. This year’s candidates are from 5 different countries! 🌎 Join us tomorrow at the start of the Rhoads Research Lecture, where the winner will be announced!
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RT @LifeWithoutDiet: One of my OG nutrition Twitter friends, @LSChapple, discussing how metabolism influences outcomes from augmented nutri….
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RT @LifeWithoutDiet: @LSChapple Indirect calorimetry measures a patients’ calorie usage but not what they NEED. These are two different thi….
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