Longevity Roadmap
@LRMpodcast
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The podcast that explores the curious mind of Buck Joffrey. Join us and venture beyond the realm of finance and discover Buck's passions for health & longevity.
Joined May 2023
Happy holidays: The https://t.co/E7jsiKu6i6 table is now fully updated thanks to the work of @Mengyuan_CAI_. 5 new podcasts added including Free Radicals (w/ @teleodaniel & @EricDai_BioE), @DcodLongevity, @reachlevity, & @LRMpodcast.
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As bats age, repair mechanisms strengthen and inflammation stays controlled—suggesting aging isn’t just about damage, but regulation. Watch the full episode to see what bats reveal about aging biology: https://t.co/5vkgvYg9Od
#LongevityScience #AgingBiology #Inflammation
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Unlike other organs, brain cells (neurons) don’t regenerate easily. Watch the full episode to understand why the brain is especially vulnerable to aging and what you can do to protect your most vital organ: https://t.co/p57X9JRDvv
#BrainHealth #Neurodegeneration #HealthyAging
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If you’ve been wanting to reverse your biological age, optimize energy, and reduce risks for chronic diseases, this is your moment. 👉 Grab the Holiday Sale price before it ends: https://t.co/nxC3Si4Z3h
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The effect isn’t cellular replacement — it’s biological instruction. That distinction is central to understanding what regenerative medicine can and can’t do. Watch the full episode with @bioXcellerator here: https://t.co/eMTgCekXUr
#stemcellscience #regenerativeMedicine
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“Stem cells” aren’t inherently equal. Watch the full episode for a comprehensive discussion on stem cells with @bioXcellerator, and what they can do for your health: https://t.co/eMTgCekXUr
#stemcells #regenerativemedicine #longevityscience #clinicalmedicine #biotech
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Neurodegenerative diseases aren’t driven by suddenly producing “bad” proteins later in life. The problem is what aging quietly breaks: the brain’s cleanup systems. Watch the full episode: https://t.co/EVorBA6N6V
#Neurodegeneration #AlzheimersDisease #ParkinsonsDisease
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🎄 Holiday Sale: $1,997 → $197 🎄 The Longevity Roadmap Masterclass is 90% OFF for a limited time. If you’ve been wanting to reverse your biological age, optimize energy, and reduce risks for chronic diseases, this is your moment: https://t.co/nxC3Si4Z3h
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Chaperone-mediated autophagy doesn’t just “slow down” with age — the entire architecture of the recycling system breaks. Watch the full breakdown with Prof. Ana Maria Cuervo: https://t.co/EVorBA6N6V
#LongevityRoadmap #CellularAging #Autophagy #CMA #AgingResearch
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Cells don’t just recycle—they make selective decisions about which proteins should be dismantled and which should be preserved. Watch the full episode to see why these mechanisms matter for aging and long-term cellular stability: https://t.co/EVorBA6fhn
#Longevity #Autophagy
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This week, Prof. Ana Maria Cuervo breaks down a major but overlooked driver of aging: the decline of chaperone-mediated autophagy (CMA)—the pathway cells use to identify and remove damaged proteins. Watch now: https://t.co/EVorBA6N6V
#AnaMariaCuervo #ChaperoneMediatedAutophagy
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When a biological fingerprint appears, is it the spark—or the smoke? Watch the full episode on brain resilience and aging: https://t.co/TeC9aa8RiN
#AlzheimersResearch #Neurodegeneration #Biomarkers #BrainHealth #LongevityScience
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Emerging evidence suggests facial aging could reflect inherited longevity traits and biological resilience more accurately than a birthdate ever could. Watch the full episode: https://t.co/yBZ2Y6Scjt
#ThrowbackThursday #longevity #agingresearch #biologicalage #healthspan
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Young plasma can reawaken stem cells, sharpen immune function, and push multiple tissues toward a younger state. Full episode: https://t.co/TeC9aa9p8l
#Parabiosis #AgingScience #LongevityResearch #Rejuvenation #AntiAgingScience
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Proteins may be the most powerful early indicators of neurological risk we’ve ever had. Watch the full episode to see how protein fingerprints are redefining early detection: https://t.co/TeC9aa8RiN
#BrainHealth #Proteomics #Biomarkers #Neurodegeneration #AgingScience
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This week on Longevity Roadmap, Dr. Tony Wyss-Coray joins us to explore how proteomics, systemic signaling, and machine-learning insights are reshaping our understanding of cognitive aging. Watch the full episode https://t.co/gF9o0j3S5r
#BrainAging #Proteomics #HealthyAging
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Fresh-frozen Alzheimer’s brains show the same signature the imaging studies hinted at: a sharp drop in cytochrome oxidase activity and clear evidence of mitochondrial failure in the cortical layers where neurons deteriorate first. Watch the full episode https://t.co/RdMlGKLfyn
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To see how energy deficits drive brain aging—and why targeting mitochondrial metabolism may be the key to preventing dementia—watch the full episode with Dr. Francisco González-Lima: https://t.co/RdMlGKLfyn
#BrainMetabolism #Mitochondria #BrainAging #CognitiveDecline
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This week, Dr. Francisco González-Lima breaks down why brain aging is fundamentally a metabolic problem—not a protein one. We dig into cytochrome oxidase, mitochondrial dysfunction, oxygen use, and emerging therapies. Watch now: https://t.co/RdMlGKLfyn
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