Time is critical in AAV: dampening kidney inflammation prevents damage.Why not target effector T cells - leave other T cells alone?.Our paper in @NDTSocial defines IL-7Ra as a target.Anti-IL-7Ra Abs are in Phase 2 trials - alopecia @Q32Bio ?an AAV therapy.

RT @anzvasc: Whether you're coming from across the globe or just hopping over from a nearby city, there’s an itinerary to Melbourne with yo….

Key points.🔹🥱Exhausted kidney IL-7Ra-PD-1+ cells.🔹😡Effector memory kidney IL-7Ra+ T cells.🔹IL-7Ra+ CD4+ & CD8+ cells had much in common .🔹Neutralising the IL-7Ra in active autoimmunity reduced kidney injury.🔹Anti-IL-7Ra mAbs do not kill cells but only neutralise function

RT @anzvasc: Say g'day to Kiwa the Koala - our (unofficial but totally adorable) mascot! Subscribe to our e-newsletter to follow all the la….

@SCSMonash @MonashCID.

IL-7Ra signalling in AAV links to relapse/resistance.Our recent paper .🔹defined activated & exhausted T cells in experimental AAV kidneys.🔹neutralised IL-7Ra - a non-depleting mAb - to limit ANCA-associated GN.Similar mAbs are in Phase 2 clinical trials.

RT @anzvasc: Extend your visit to #VasculitisMelbourne2026 and explore what Australia has to offer!.From its stunning natural beauty, rich….

RT @anzvasc: Calling Young Scientists - don't miss your opportunity to be part of the 22nd International Vasculitis Workshop 2026. Join lea….

RT @drdavidliew: On behalf of @anzvasc, I’d love to invite everyone at #EULAR2025 to join us at the International Vasculitis Workshop in Fe….

RT @anzvasc: Don’t forget to register for #VasculitisMelbourne2026 - the first Vasculitis Workshop in the Southern Hemisphere!.Visit https:….

RT @anzvasc: We’re calling on researchers, clinicians, and educators—share your work with the global vasculitis community!.Submit your abst….

RT @anzvasc: Registration is NOW OPEN! #VasculitisMelbourne2026.Register now at Don’t miss this unprecedented oppo….

Thanks to #vasculitis expert Steve McAdoo speaking @MonashHealth today - and checking out Melbourne on the exact day registration opens for the 2026 International Vasculitis Workshop . #VasculitisMelbourne2026

RT @anzvasc: The #VasculitisMelbourne2026 academic committees are well represented by women.🔹Co-convenors - 2 of 3 are women.🔹Local Organis….

#VasculitisMelbourne2026.

RT @anzvasc: Come join us for #IVW2026 in Australia, and in the vibrant city of Melbourne! February offers perfect summer weather - ideal f….

RT @anzvasc: Don't forget vasculitis when it comes to the rare and wonderful on #RareDiseaseDay! Support their cause on .

RT @anzvasc: We are thrilled to be hosting #IVW2026 happening in Melbourne, Australia from 21 - 25 February 2026. If you are interested in….

RT @anzvasc: Melbourne Weather: 21 Feb 2025 - exactly one year until #vasculitis2026.Great weather here in Melbourne - crisp morning, 31 de….

How good are #vasculitis physicians at estimating overall health?.Do they think patients are more healthy than they are? .🔹Physician/patient agreement pretty good.🔹Physicians more often underestimated health.🔹Nephrol/Rheumatol/physician/trainee similar.